Search Results - alan+meeker

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Generation of Novel Prostate Cancer Cell Lines that Employ the Alternative Lengthening of Telomeres (ALT) Telomere Maintenance Mechanism

Unmet NeedInstead of telomerase, approximately 10% of cancers maintain telomeres via a DNA template dependent mechanism called Alternative Lengthening of Telomeres (ALT). The ALT pathway is dependent on homologous recombination and tightly linked to recurrent cancer-associated somatic inactivating mutations of ATRX or DAXX, genes encoding chromatin...

Published: 7/4/2024 | Inventor(s): Christopher Heaphy, Mindy Graham, Alan Meeker, Jacqueline Brosnan-Cashman, Michael Haffner, Anthony Rizzo

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Mutations of ATRX in Brain Tumors

C11618: Novel Molecular Diagnostic for Aggressive Brain TumorsNovelty: A genetic mutation in the ATRX or DAXX genes previously unknown for its presence in various aggressive brain tumors was discovered and thereby provides an attractive diagnostic opportunity.Value Proposition: Previously unreported changes in ATRX or DAXX gene’s amino acid sequence...

Published: 7/4/2024 | Inventor(s): Luis Diaz, Alan Meeker, Hai Yan, Nickolas Papadopoulos, Darell Bigner, Yuchen Jiao, Ralph Hruban, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Biomarker, Brain Cancer, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers