Search Results - jacqueline+brosnan-cashman

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Generation of Novel Prostate Cancer Cell Lines that Employ the Alternative Lengthening of Telomeres (ALT) Telomere Maintenance Mechanism

Unmet NeedInstead of telomerase, approximately 10% of cancers maintain telomeres via a DNA template dependent mechanism called Alternative Lengthening of Telomeres (ALT). The ALT pathway is dependent on homologous recombination and tightly linked to recurrent cancer-associated somatic inactivating mutations of ATRX or DAXX, genes encoding chromatin...

Published: 3/13/2025 | Inventor(s): Christopher Heaphy, Mindy Graham, Alan Meeker, Jacqueline Brosnan-Cashman, Michael Haffner, Anthony Rizzo

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

A p105-based NF-(kappa) B Super repressor

C04290: A p105-based NF-(kappa) B Super repressor Technical Details: Nuclear factor (NF)-kB is a family of transcription factors that regulate immune and inflammatory responses, programmed cell death (apoptosis), and developmental processes. In normal cells, NF-kB is latent, and is activated transiently by stimuli and stresses. However, under pathological...

Published: 3/13/2025 | Inventor(s): Li Lin

Keywords(s): Biologics, Cancers, Chemotherapy, Disease Indication, Nucleic Acid, Single, Skin Cancer, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Dermatology, Clinical and Disease Specializations > Oncology > Skin Cancer, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Therapeutic Modalities > Targets, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities