Search Results - michael+haffner

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Generation of Novel Prostate Cancer Cell Lines that Employ the Alternative Lengthening of Telomeres (ALT) Telomere Maintenance Mechanism

Unmet NeedInstead of telomerase, approximately 10% of cancers maintain telomeres via a DNA template dependent mechanism called Alternative Lengthening of Telomeres (ALT). The ALT pathway is dependent on homologous recombination and tightly linked to recurrent cancer-associated somatic inactivating mutations of ATRX or DAXX, genes encoding chromatin...

Published: 3/13/2025 | Inventor(s): Christopher Heaphy, Mindy Graham, Alan Meeker, Jacqueline Brosnan-Cashman, Michael Haffner, Anthony Rizzo

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

C12052 - LAPC4-CR a Castration Resistant Human Prostate Cancer Cell Line

Novelty: New LAPC4-CR cell line which shows properties of castration resistant tumors, both in vitro and in vivo.Value Proposition: Current treatments for metastatic prostate cancer involve castration, resulting in low serum androgen levels. After intervention and treatment, most tumors develop resistance to this therapy and present as castration resistant...

Published: 3/13/2025 | Inventor(s): Srinivasan Yegnasubramanian, Michael Haffner, William Nelson, Nicolas Wyhs

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mouse Cell Lines, Prostate Cancer

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Prostate Cancer

C12051 - VCaP-CR a Castration Resistant Human Prostate Cancer Cell Line

Novelty: New VCaP-CR cell line that shows properties of castration resistant tumors, both in vitro and in vivo. Value Proposition: Current treatments for metastatic prostate cancer involve castration, resulting in low serum androgen levels. After intervention and treatment, most tumors develop resistance to this therapy and present as castration resistant...

Published: 3/13/2025 | Inventor(s): Srinivasan Yegnasubramanian, Michael Haffner, William Nelson, Nicolas Wyhs

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Prostate Cancer

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Prostate Cancer

5-hydroxymethylcytosine in Human Cancers

C11663: 5hmC: A Novel Marker for Cancer DetectionNovelty: The invention is a novel marker that can be detected in cancers using immunohistochemical (IHC) staining methods.Value Proposition: Cancers are often diagnosed in advanced stages, jeopardizing cancer patients’ chance to survive. This technique can detect different types of solid cancers...

Published: 3/13/2025 | Inventor(s): William Nelson, Angelo Demarzo, Alcides Chaux, Srinivasan Yegnasubramanian, Michael Haffner

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics