Search Results - angelo+demarzo

5 Results

Sort By:

Cell Line Microarray of Seven NCI60 Cell Lines

TITLE: Cell Line Microarray of Commonly used Cancer Cell Lines CASE NUMBER: C14193 UNMET NEEDAn emerging concern in the field of cancer pathology is the reliability and reproducibility of immunohistochemical (IHC), in situ hybridization (ISH), and fluorescence in situ hybridization (FISH) methods to evaluate gene expression and genome alterations...

Published: 3/13/2025 | Inventor(s): Angelo Demarzo, David Esopi, Bonnie Gambichler, Srinivasan Yegnasubramanian

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines

5-hydroxymethylcytosine in Human Cancers

C11663: 5hmC: A Novel Marker for Cancer DetectionNovelty: The invention is a novel marker that can be detected in cancers using immunohistochemical (IHC) staining methods.Value Proposition: Cancers are often diagnosed in advanced stages, jeopardizing cancer patients’ chance to survive. This technique can detect different types of solid cancers...

Published: 3/13/2025 | Inventor(s): William Nelson, Angelo Demarzo, Alcides Chaux, Srinivasan Yegnasubramanian, Michael Haffner

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

A Novel Cell Line TMA Approach for Tissue Biomarker Development and Validation

C11481: Novel Tissue Microarray for Standardized Cancer StudyNovelty: This technology uses a Tissue Microarray (TMA) to standardize the study of cancer phenotypes.Value Proposition: Current evaluative methods for the study of cancer phenotypes and research reagents are not standardized. Commercial vendors of TMA have no controls, leading to variable...

Published: 3/13/2025 | Inventor(s): David Esopi, Bonnie Gambichler, Srinivasan Yegnasubramanian, Angelo Demarzo

Keywords(s): Cancer Cells, Cancers, Cell Model, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Target-based Screening Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics

COMPARE-MS: A Novel Technique for Rapid, Sensitive, And Accurate Detection of DNA Methylation

C04871: COMPARE-MS: A Novel Technique for Rapid, Sensitive, And Accurate Detection of DNA MethylationTechnical Details: Hypermethylation of CpG island (CGI) sequences is a nearly universal somatic genome alteration in cancer. The rapid and sensitive detection of DNA hypermethylation can aid in cancer diagnosis and risk stratification but its detection...

Published: 3/13/2025 | Inventor(s): Xiaohui Lin, Srinivasan Yegnasubramanian, Angelo Demarzo, William Nelson

Keywords(s): Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Antibody to Human DNA Methyltransferase 1

C04328: Antibody to Human DNA Methyltransferase 1 Technical Details: We successfully prepared a polyclonal rabbit antibody to a peptide derived from the N-terminus of human DNMT1 (the sub-contractor was provided with the peptide sequence, synthesized the peptide, injected rabbits, and collected the immune sera; we characterized the antibodies and...

Published: 3/13/2025 | Inventor(s): Angelo Demarzo, William Nelson

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Peptides, Polyclonal Antibodies, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors