Search Results - peptides

12 Results

Sort By:

Intracellular actuator that generates and manipulates physical force in living cells

Marketing Summary DraftIntracellular actuator that generates and manipulates physical force in living cellsJHU Ref #: C14896Value PropositionPhysical force generation inside living cells via light irradiation and chemical treatmentThis research tool can be applied to arbitrary intracellular targets in a specific and spatiotemporal mannerSystem is built...

Published: 3/13/2025 | Inventor(s): Takanari Inoue, Hideki Nakamura, Elmer Rho

Keywords(s): Discovery/Research Tools, Peptides, Recombinant Proteins, Research Reagent, Translational Research Biomarker

Category(s):

An N-terminal Signal Peptide Increases Total Expression and Enhances Surface Trafficking of Olfactory Receptors

Unmet NeedThe present invention is based on the discovery of an N-terminal tag sequence which aids in olfactory receptor trafficking. When expressed exogenously in mammalian cells, olfactory receptors (ORs) fail to traffic to the cell surface. This is a problem as receptor ligands cannot be assayed unless the receptor is present on the cell surface....

Published: 3/13/2025 | Inventor(s): Niranjana Natarajan, Blythe Shepard, Jennifer Pluznick

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Peptides, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Simulation and Database-guided Antimicrobial Peptide Evolution

Unmet Need Antimicrobial peptides (AMPs) are typically amphiphilic peptides that have selectively to target and kill bacteria at low micromolar concentrations, often without harming mammalian cells and are thus an excellent candidate for drug development.Technology OverviewThe new methodology combines molecular dynamic simulations and database-guided...

Published: 3/13/2025 | Inventor(s): Charles Chen, Martin Ulmschneider

Keywords(s): Computational Modeling Tool, Discovery/Research Tools, In Silico Research Tool, In Vitro Research Tool, Peptides, Recombinant Proteins, Research Instrument, Research Reagent

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Computers, Electronics & Software

MH-Gag plasmid (Chimeric MLV/HIV-Gag) aka pSR389

TITLE: MH-Gag plasmid (Chimeric MLV/HIV-Gag) aka pSR389CASE NUMBER: C13554ABSTRACTJHU researchers made use of a chimeric Moloney murine leukemia virus (MMLV)-HIV-1 Gag in which the p17 matrix domain of HIV-1 was replaced with the p15 matrix and p12 domains from MMLV. Murine cells expressing this construct released significant amounts of VLPs. The construct...

Published: 3/13/2025 | Inventor(s): Robert Siliciano, Soon Boon Wong

Keywords(s): Cloning Reagents, Discovery/Research Tools, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Peptides, Plasmid, Recombinant Proteins, Research Reagent, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Small Peptide Stimulator of NHE3, the Brush Border Epithelial Na/H Exchanger

C11498: Effective Treatment of Acute Diarrhea Using a Novel Peptide Modification Novelty: A peptide derived from the Sodium-Hydrogen Exchanger-3 (NHE-3) protein that increases sodium absorption in the intestine, aiding rehydration and can be used as a therapeutic for acute diarrhea. Value Proposition: The Center for Disease Control recommends...

Published: 3/13/2025 | Inventor(s): Randen Patterson, Damian Van Rossum, Nicholas Zachos, Mark Donowitz

Keywords(s): Acute Diarrhea, Basic Research Biomarker, Biologics, Cell Signaling, Discovery/Research Tools, Disease Indication, Gastrointestinal Disorders, Molecular Switches/Receptors, Peptide, Peptides, Recombinant Proteins, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Peptides, Clinical and Disease Specializations > Gastroenterology

Rabbit Serum 5690

C10529: Rabbit Serum 5690: Antibodies Against Rat Lmo7Value Proposition: • Polyclonal antibodies against rat Lmo7Technical Details: Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins. The nuclear lamina...

Published: 3/13/2025 | Inventor(s): Katherine Wilson

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Genetic Disorders, Muscular Disorders, Peptides, Polyclonal Antibodies, Proteomics/Immunoassays, Proteomics/Immunoassays Antiserum, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Genetic Diseases, Clinical and Disease Specializations > Rare Diseases, Clinical and Disease Specializations > Musculoskeletal

Rabbit Serum 4278

C10525: Rabbit Serum 4278: Antibodies Against Human MAN1 Technical Details: Nuclear lamina is a dense fibrillar network inside the nucleus of eukaryotic cells composed of intermediate filaments (lamins) and membrane associated proteins called lamin-associated membrane proteins. The nuclear lamina provides mechanical support, regulates important cellular...

Published: 3/13/2025 | Inventor(s): Katherine Wilson

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Peptides, Polyclonal Antibodies, Proteomics/Immunoassays, Proteomics/Immunoassays Antiserum, Recombinant Proteins, Research Reagent

A Novel Method for Unambiguous, Quantitative Detection of Full-length and Truncated Thioredoxin from Complex Biological Samples

Unmet Need: Thioredoxin (TRX) is an essential protein that acts as antioxidant and can be used as a general marker of many different disease conditions involving oxidative stress. Currently, the level of thioredoxin is detected using ELISA methods. While potentially informative, there may be several problems inherent in this technique as this protein...

Published: 3/13/2025 | Inventor(s): Mary Zink, Susan Trow-Follstaedt, David Graham

Keywords(s): Assay, Basic Research Biomarker, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, Peptides, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays

Antibody to Human DNA Methyltransferase 1

C04328: Antibody to Human DNA Methyltransferase 1 Technical Details: We successfully prepared a polyclonal rabbit antibody to a peptide derived from the N-terminus of human DNMT1 (the sub-contractor was provided with the peptide sequence, synthesized the peptide, injected rabbits, and collected the immune sera; we characterized the antibodies and...

Published: 3/13/2025 | Inventor(s): Angelo Demarzo, William Nelson

Keywords(s): Antibodies, Basic Research Biomarker, Discovery/Research Tools, Peptides, Polyclonal Antibodies, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

N-Terminal NR1 Sub-unit Antibody

C03958: N-Methyl-D-aspartate (NMDA) Receptor NR1 Subunit Polyclonal AntibodyValue Proposition: JHU scientists have developed a polyclonal antibody to the NR1 Subunit of the N-Methyl-D-aspartate (NMDA) Receptor.Looking for Partners: This technology encompasses an antibody specific for the NR1 Subunit of the NMDA Receptor. It has the potential to be commercialized...

Published: 3/13/2025 | Inventor(s): Richard Huganir

Keywords(s): Antibodies, Basic Research Biomarker, Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Discovery/Research Tools, In Vitro Diagnostics, Peptides, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Antibodies

1 2