Search Results - jennifer+pluznick

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Olfactory Receptor Trafficking in Mammalian Cells

Invention novelty: The invention is a method and composition to ensure the cell surface expression of olfactory receptors (ORs) in heterologous systems.Value Proposition: Olfactory receptors are difficult to express in cell systems from which they are not derived. The ORs tend to remain intracellular in such systems, and use of these systems to identify...

Published: 3/13/2025 | Inventor(s): Jennifer Pluznick, Blythe Shepard, Niranjana Natarajan

Keywords(s): Discovery/Research Tools, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

An N-terminal Signal Peptide Increases Total Expression and Enhances Surface Trafficking of Olfactory Receptors

Unmet NeedThe present invention is based on the discovery of an N-terminal tag sequence which aids in olfactory receptor trafficking. When expressed exogenously in mammalian cells, olfactory receptors (ORs) fail to traffic to the cell surface. This is a problem as receptor ligands cannot be assayed unless the receptor is present on the cell surface....

Published: 3/13/2025 | Inventor(s): Niranjana Natarajan, Blythe Shepard, Jennifer Pluznick

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Peptides, Recombinant Proteins, Research Reagent

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools

Olfr90 and Fungal Volatiles

Unmet NeedIncreasingly, invasive mold infections have been recognized in people who are immune compromised by genetic conditions, aging, other infections (e.g. HIV) and modern medicine (e.g. transplantation). Moreover, increasing evidence points to the role of these organisms as causes of environmental toxicities and industrial spoilage. An over-abundance...

Published: 3/13/2025 | Inventor(s): Kieren Marr, Jennifer Pluznick, Victoria Halperin-Kuhns

Keywords(s): Assay, Biomarker, Clinical Diagnostics, Disease Indication, Environmental Sensing, Fungal Infections, Imaging and Sensing Systems, In Vitro Diagnostics, Mechanism-of-action Biomarker, Sensing Modality, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Fungal Infections, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities