Search Results - research+reagent

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A natural sg-tracrRNA for S. pyogenes transcriptional repression and cleavage

Unmet Need:CRISPR-Cas9 from Streptococcus pyogenes is the most commonly used due to Cas9’s ability to act as a singular protein and its high gene cutting activity (see Knott and Nakade). Despite the widespread use of CRISPR-Cas9, limitations remain in the efficiency with which precise genome editing occurs (see Banan). CRISPR-Cas9 creates a double-stranded...

Published: 3/13/2026 | Inventor(s): Joshua Modell

Keywords(s): Cloning Reagents, Discovery/Research Tools, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids

bio-IB3

Unmet NeedAccording to the CDC, approximately 5.8-million individuals aged 65+ in the United States were living with Alzheimer’s disease in 2020 (see CDC). Alzheimer’s disease leads to memory impairment that progressively affects the ability of individuals to conduct daily tasks and worsens with time. Currently, the diagnosis of Alzheimer’s disease...

Published: 3/12/2026 | Inventor(s): Esther Oh, Stina Tucker, David Borchelt, Juan Troncoso

Keywords(s): Alzheimer's Disease, Antibodies, Biologics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Neurodegeneration, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Geriatrics, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Neurology > Alzheimer's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration

Transposon-Based Reporter Vector for High-Efficiency Regulatory DNA Sequence Screening

Value Proposition· Enhanced germline transmission - Tol2 transposon system provides superior integration efficiency compared to episomal DNA and alternative transposon systems· Streamlined cloning workflow - Gateway cloning system enables rapid insertion of test sequences without traditional restriction/ligation steps· Real-time...

Published: 3/12/2026 | Inventor(s): Elizabeth Grice, Shannon Fisher, Andrew McCallion

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

Low Cost Regulated Genetic Switch for Saccharomyces Cerevisiae

Low Cost Regulated Genetic Switch for Saccharomyces CerevisiaeJHU REF: C12857 Invention Novelty: This technology is a method of using a low cost regulated system for controlling gene expression in the yeast Saccharomyces cerevisiae. Value Proposition:Budding yeast Saccharomyces cerevisiae is one of the most important organisms in biotechnology. Currently...

Published: 3/12/2026 | Inventor(s): Jef Boeke, Shigehito Ikushima

Keywords(s): Cell Signaling, Discovery/Research Tools, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent, Yeast Model

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Yeast Model

Human LRRK2 cDNA

Studies have shown that mutations in the LRRK2 gene are the most common determinants of late-onset Parkinsons disease (PD) susceptibility. These cDNA vectors comprise wild type LRRK2 cDNA or mutated LRRK2 cDNA that can be expressed in cells to decipher the biochemical pathways and pathology of PD. Other advantages include:• Produced from human source...

Published: 3/12/2026 | Inventor(s): Ted Dawson

Keywords(s): Basic Research Biomarker, Cloning Reagents, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Nucleotide, Parkinson's Disease, Research Reagent

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Parkinson's Disease

Vascular Endothelial Growth Factor and Substrate Mechanics Regulate Vascular Tubulogenesis

Unmet Need:In recent decades, postnatal vasculogenesis has been considered to be an important mechanism for neovascularization via circulating endothelial progenitor cells (EPCs) derived from marrow. Since then, EPCs have been proposed as a potential tool for treating vascular disease, either through infusion to the site of vascularization or ex vivo...

Published: 3/12/2026 | Inventor(s): Donny Hanjaya-Putra, Sharon Gerecht

Keywords(s): Buffer/Media Solution, Culture Media, Discovery/Research Tools, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools

Incorporation of Lysine Tags as a Universal System for Controlling Protein Expression

Value Proposition· Precise and Tunable Protein Translation Control: Poly(A) track length can be varied from 1-12 AAA codons, providing precise and adjustable control over protein output.· Minimal Complexity: This technology offers predictable, graded control of protein expression using only a short DNA sequence insert—no external inducers,...

Published: 3/12/2026 | Inventor(s): Dorothy Green, Sergej Djuranovic

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Nucleotide, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

Intracellular actuator that generates and manipulates physical force in living cells

Marketing Summary DraftIntracellular actuator that generates and manipulates physical force in living cellsJHU Ref #: C14896Value PropositionPhysical force generation inside living cells via light irradiation and chemical treatmentThis research tool can be applied to arbitrary intracellular targets in a specific and spatiotemporal mannerSystem is built...

Published: 3/13/2026 | Inventor(s): Takanari Inoue, Hideki Nakamura, Elmer Rho

Keywords(s): Discovery/Research Tools, Peptides, Recombinant Proteins, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Vectors & Plasmids

Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 3/12/2026 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Identification of RNF43 Mutations in Pancreatic Cysts

Unmet Need· One third of diagnoses for surgical resection of pancreatic cysts are incorrect, leading to unnecessary surgery, medical risk, and high costs (Hammel, 2002). The current standard of care for determining pancreatic cyst type is based solely on symptom progression and imaging criteria, and histopathological analysis is only available...

Published: 3/12/2026 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Jian Wu, Anirban Maitra, Ralph Hruban, Marco Dal Molin

Keywords(s): Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, Nucleotide, Pancreatic Cancer, Research Reagent, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers

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