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Smooth-muscle-like-cells (SMLCs) Derived from Human Embryonic Stem Cells (hESCs) Support Cord-like Structure in vitro

This invention relates, e.g., to a method for differentiating mammalian (e.g., human) pluripotent stem cells (PSCs) into smooth muscle-like cells (SMLCs) in vitro, comprising a) plating a single-cell suspension of PSCs that are smaller than 50 μm at a seeding concentration of about 5×104 cells/cm2-about 1×105 cells/cm2 onto a suitable surface, and culturing...

Published: 3/13/2025 | Inventor(s): Sharon Gerecht, Maureen Wanjare, Elaine Vo, Donny Hanjaya-Putra

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Human Cell Lines, Implanted Device, Implants, In Vitro Research Tool, Stem Cells, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices

Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Stem Cells, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Human Cell Lines