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Search Results - cell+lines
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A Novel-fate Marking Strategy to Permanently Tag Hypoxic Cancer Cells
Value Proposition· Permanently labels cells that have experienced hypoxia, enabling long-term tracking· Captures tumor evolution by identifying cells with past hypoxia exposure, not just at the time of tissue collection· Enables investigation of metastasis by tracking cells from hypoxic niches that may retain aggressive phenotypes· Supports...
Published: 1/22/2026
|
Inventor(s):
Daniele Gilkes
,
Ines Godet
Keywords(s):
Breast Cancer
,
Cancers
,
Cardiovascular Diseases
,
Cell Lines
,
Discovery/Research Tools
,
Disease Indication
,
Human
Cell Lines
,
In Vitro Research Tool
,
In Vivo Research Tool
,
Mouse Model
,
Translational Research Biomarker
Category(s):
Clinical and Disease Specializations > Oncology
,
Clinical and Disease Specializations > Cardiovascular
,
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools >
Cell Lines
Muscular Dystrophy
Cell Lines
Unmet NeedFacioscapulohumeral muscular dystrophy (FSHD) is a complex neuromuscular disorder affecting 1 in 20,000 individuals. The disease is characterized by progressive wasting of facial, upper arm and shoulder girdle muscles. FSHD has variable age of onset, ranging from infant to late adult; and approximately one-third of patients lose the ability...
Published: 1/22/2026
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Inventor(s):
Kathryn Wagner
Keywords(s):
Cell Lines
,
CNS and Neurological Disorders
,
Discovery/Research Tools
,
Disease Indication
,
Human
Cell Lines
,
In Vitro Research Tool
,
Muscular Dystrophy
Category(s):
Technology Classifications > Research Tools >
Cell Lines
,
Clinical and Disease Specializations > Musculoskeletal > Muscle Atrophy
SCA12 Tools – SCA12 Fibroblasts, iPSCs and Polyclonal Antibodies to Investigate SCA12
Value PropositionFirst in class patient-derived biological tools for investigation of SCA12, a rare neurodegenerative disease with no known cure. Unmet NeedSpinocerebellar ataxia type 12 (SCA12) is a rare neurodegenerative disease that affects the cerebellum, commonly resulting in upper limb tremors and muscle spasms, with some patients reporting a...
Published: 1/22/2026
|
Inventor(s):
Russell Margolis
,
Pan Li
,
Christopher Ross
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Discovery/Research Tools
,
Human
Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Human
Cell Lines
,
Clinical and Disease Specializations > Neurology > Neurodegeneration
TH-2A-CreER Mice
Value Proposition· Enhanced labeling efficiency: The TH-2A-CreER mouse line achieves higher labeling efficiency compared to existing mouse lines through the 2A peptide system that ensures elevated CreER expression levels· Multi-population targeting: Enables labeling and functional manipulation of TH-expressing neuronal populations including...
Published: 1/22/2026
|
Inventor(s):
David Ginty
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Discovery/Research Tools
,
In Vitro Research Tool
,
Mouse
Cell Lines
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools >
Cell Lines
,
Technology Classifications > Research Tools
K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells
C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial
cell lines
. Looking for Partners: The cell lines described in this...
Published: 1/22/2026
|
Inventor(s):
Ben Ho Park
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Cell Model
,
Discovery/Research Tools
,
Epithelial Cells
,
Human
Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools >
Cell Lines
,
Technology Classifications > Research Tools > Human
Cell Lines
,
Technology Classifications > Research Tools
Alpha 2 Collagen VIII (Col8a2) Q455K Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy
Unmet Need:Fuchs’ endothelial corneal dystrophy (FECD) is a genetic disease affecting the cornea and is estimated to affect 7% of the adult population (see Aiello et al. 2022). The first genetic defect shown to cause FECD was a point mutation in the alpha 2 collagen 8 gene (Col8a2). The disease results in a buildup of fluid in the cornea and causes...
Published: 1/22/2026
|
Inventor(s):
Albert Jun
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Corneal Dystrophy
,
Discovery/Research Tools
,
Disease Indication
,
Eye Disorders
,
Fuchs' Endothelial Corneal Dystrophy
,
Fuchs Endothelial Corneal Dystrophy (FECD)
,
In Vitro Research Tool
,
Mouse
Cell Lines
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Rare Diseases
,
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools >
Cell Lines
,
Clinical and Disease Specializations > Ophthalmology
,
Technology Classifications > Research Tools
,
Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy
,
Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy
Isogenic SF3B1
cell lines
for drug discovery
SF3B1 mutations are present in a number of cancers. These mutations cause abnormal splicing within human cells and can lead to genomic alterations that confer cancerous phenotypes. Our research has led to the creation of isogenic
cell lines
that have specific mutations within the SF3B1 gene, thus mimicking human cancer mutations. In addition, we have...
Published: 1/22/2026
|
Inventor(s):
Ben Ho Park
,
William Dalton
Keywords(s):
Cell Lines
,
Discovery/Research Tools
,
Human
Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools >
Cell Lines
,
Technology Classifications > Research Tools > Human
Cell Lines
Pkd1 mouse models
We have introduced lox P sites into introns 2 and 4 of the mouse Pkdl gene which allows its regulated inactivation. Mutations in human PKD1 account for at-85% of all cases of human autosomal dominant polycystic kidney disease. We have shown that we can recapitulate a human-like disease presentation using inducible Cre-recombinases. This model is a powerful...
Published: 1/22/2026
|
Inventor(s):
Gregory Germino
,
Heiner Westphal
,
Klaus Piontek
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Discovery/Research Tools
,
In Vitro Research Tool
,
Mouse
Cell Lines
Category(s):
Technology Classifications > Research Tools > Animal Models
,
Technology Classifications > Research Tools >
Cell Lines
,
Technology Classifications > Research Tools
ENGINEERED CELLS EXPRESSING PROSTATE-SPECIFIC MEMBRANE ANTIGEN (PSMA) OR A MODIFIED FORM THEREOF AND RELATED METHODS
Unmet NeedProstate cancer is the second leading cause of cancer related death in American men and it is estimated that approximately 164,690 new cases will be diagnosed in 2018. Various treatment strategies, including surgery, radiation and chemotherapy, exist for prostate cancer but their success depends on the stage of the cancer at diagnosis. Novel...
Published: 1/22/2026
|
Inventor(s):
Martin Pomper
,
David Huss
,
Hyam Levitsky
,
Il Minn
Keywords(s):
Biologics
,
Cancers
,
Cell Lines
,
Discovery/Research Tools
,
Disease Indication
,
In Vitro Research Tool
,
Large Animal
Cell Lines
,
Therapeutic Matter
,
Therapeutic Substance
,
Therapeutics
,
Translational Research Biomarker
,
Whole cell
Category(s):
Clinical and Disease Specializations > Oncology
,
Technology Classifications > Research Tools >
Cell Lines
,
Technology Classifications > Therapeutic Modalities > Biologics
,
Technology Classifications > Therapeutic Modalities > Cell Therapies
Hypoxia-inducible factor reporter
cell lines
Unmet NeedLow oxygen levels are a characteristic of many types of solid tumors. High levels of HIF1α, the transcription factor responsible for energy utilization under hypoxic conditions, has been implicated in tumor growth and resistance, angiogenesis, and poor patient prognosis. For these reasons, HIF1α remains an attractive target for novel cancer...
Published: 1/22/2026
|
Inventor(s):
Peter Espenshade
,
Wei Shao
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Discovery/Research Tools
,
In Vitro Research Tool
,
Mouse
Cell Lines
Category(s):
Technology Classifications > Research Tools >
Cell Lines
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