Search Results - klaus+piontek

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Pkd1 mouse models

We have introduced lox P sites into introns 2 and 4 of the mouse Pkdl gene which allows its regulated inactivation. Mutations in human PKD1 account for at-85% of all cases of human autosomal dominant polycystic kidney disease. We have shown that we can recapitulate a human-like disease presentation using inducible Cre-recombinases. This model is a powerful...

Published: 3/13/2025 | Inventor(s): Gregory Germino, Heiner Westphal, Klaus Piontek

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Pkd1(superscript ko) Mouse Line (Pkd1[superscript tm1Ggg]; it is also known as Pkd1[superscript beta-gal-null])

C10754: Mouse Model For Polycystic Kidney Disease Gene KnockoutNovelty: This technology is a mutant mice containing beta-galactosidase instead of Pkd1 gene to study the pathogenesis of autosomal dominant polycystic kidney disease.Value Proposition: Autosomal dominant polycystic kidney disease is characterized by cyst formation in the kidney and other...

Published: 3/13/2025 | Inventor(s): Klaus Piontek, Gregory Germino

Keywords(s): Basic Research Biomarker, Biomarker, Cell Lines, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, In Vivo Research Tool, Kidney Disorders, Knock Out Mouse Model, Mouse Cell Lines, Mouse Model, Polycystic Kidney Disease

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Nephrology > Polycystic Kidney Disease, Technology Classifications > Diagnostics > Biomarkers