Search Results - kidney+disorders

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Method and System for the Early Detection of Acute Kidney Injury

Acute kidney injury (AKI) is a condition where the kidneys become unable to adequately filter the blood, causing toxic levels of waste to accumulate throughout the body. AKI is formally defined as a “>50% decrease in glomerular filtration rate (GFR) over a period of hours to days,” which leads to a decline in urine output over time. Measuring urine...

Published: 3/13/2025 | Inventor(s): Aaron Chang, Alexandra Sibole, Sriram Chadalavada, Madeleine Clegg, Patience Osei, Nevin Katz, Jonathan Magruder

Keywords(s): Clinical Diagnostics, Diagnostic Tool, Disease Indication, Kidney Disorders, Measurement Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics

Photo-Assisted Vascular Access Guide

Unmet NeedApproximately 600,000 patients in the United States today are on hemodialysis. In order for long-term applicability of hemodialysis, either arteriovenous fistulas (AVF) or arteriovenous grafts (AVG) are utilized. AVFs utilize the patient’s own vein and AVGs are artificial conduits that allow long-term access to the patient’s blood flow and...

Published: 3/13/2025 | Inventor(s): Andrew Schulick, Devika Singh

Keywords(s): Cancers, Disease Indication, Interventional and Surgical Systems, Kidney Disorders, Surgical Instruments, Surgical Tubing

Category(s): Clinical and Disease Specializations > Nephrology, Clinical and Disease Specializations > Oncology, Technology Classifications > Medical Devices > Surgical

Magnet Assisted Vascular Access Guide

Unmet NeedApproximately 600,000 patients in the United States today are on hemodialysis. In order for long-term applicability of hemodialysis, either arteriovenous fistulas (AVFs) or arteriovenous grafts (AVGs) are utilized. AVFs utilize the patient’s own vein while AVGs are artificial conduits that allow long term access to the patient’s blood flow...

Published: 3/13/2025 | Inventor(s): Andrew Schulick, Devika Singh

Keywords(s): Cancers, Disease Indication, Interventional and Surgical Systems, Kidney Disorders, Surgical Instruments, Surgical Tubing

Category(s): Clinical and Disease Specializations > Nephrology, Clinical and Disease Specializations > Oncology, Technology Classifications > Medical Devices > Surgical

Method of Size Measurement in Mono-vision Scope Images

Unmet NeedKidney stone disease affects up to 1 in 8 people (12%) worldwide and is commonly treated by a procedure known as flexible ureteroscopy (URS). During URS, kidney stones are fragmented and extracted through the ureter. URS involves significant intra-operative decision making since surgeons must accurately assess the size of the stone fragments...

Published: 3/13/2025 | Inventor(s): Dan Stoianovici, Brian Matlaga, Sunghwan Lim, Wesley Ludwig

Keywords(s): Disease Indication, Image Processing Software, Imaging and Sensing Systems, In Vivo Medical Imaging, Kidney Disorders, Kidney stones

Category(s): Technology Classifications > Medical Devices > Imaging, Clinical and Disease Specializations > Urology

11C-PABA as a Novel Functional Renal Imaging Agent

Unmet Need: Assessing kidney function is often essential for clinical decision making for a variety of diseases including chronic kidney disorder (CKD). CKD affects more than 30 million Americans and millions of others are at an increased risk of developing it. The gold standard for measuring renal function for diagnosing/monitoring CKD and other disorders...

Published: 3/14/2025 | Inventor(s): Sanjay Jain, Alvaro Ordonez, Camilo Ruiz-Bedoya

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Kidney Disorders, Positron Emission Tomography (PET)

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging, Clinical and Disease Specializations > Nephrology

Deletion of Kelch-like ECH-associated Protein 1 (Keap1) in Kidney Epithelial Cells Causes Hydronephrosis in Mice

Invention novelty: This invention reveals an unexpected, novel kelch-like ECH-associated protein 1 (KEAP 1) mediated signaling pathway in renal development.Value Proposition:The Nrf2-Keap1 pathway has an important role in both acute kidney injury (AKI) and chronic kidney disease (CKD). This pathway has a key regulatory function on many antioxidant and...

Published: 3/13/2025 | Inventor(s): Samatha Bandapalle, Sanjeev Noel, Hamid Rabb

Keywords(s): Basic Research Biomarker, Cell Model, Discovery/Research Tools, Disease Indication, Epithelial Cells, In Vitro Research Tool, Kidney Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Polyclonal Chicken and Rabbit Antibodies, Termed Anti-CC, Generated Using Denatured C-terminal 199 Amino Acid Fragment of Mouse Polycystin-1 Protein as Immunogen

TITLE Polyclonal chicken and rabbit antibodies, termed anti-CC, of mouse polycystin-1 protein as immunogenC13399ABSTRACTPolycystin-1 (PC1) has an essential function in renal tubular morphogenesis and disruption of its function causes cystogenesis in human autosomal dominant polycystic kidney disease. Endogenous...

Published: 3/13/2025 | Inventor(s): Feng Qian

Keywords(s): Antibodies, Basic Research Biomarker, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, In Vivo Research Tool, Kidney Disorders, Polyclonal Antibodies, Polycystic Kidney Disease, Rabbit Model, Rabbit Model Xenograft, Research Reagent, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools, Clinical and Disease Specializations > Nephrology > Polycystic Kidney Disease

Pkd1(superscript ko) Mouse Line (Pkd1[superscript tm1Ggg]; it is also known as Pkd1[superscript beta-gal-null])

C10754: Mouse Model For Polycystic Kidney Disease Gene KnockoutNovelty: This technology is a mutant mice containing beta-galactosidase instead of Pkd1 gene to study the pathogenesis of autosomal dominant polycystic kidney disease.Value Proposition: Autosomal dominant polycystic kidney disease is characterized by cyst formation in the kidney and other...

Published: 3/13/2025 | Inventor(s): Klaus Piontek, Gregory Germino

Keywords(s): Basic Research Biomarker, Biomarker, Cell Lines, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, In Vivo Research Tool, Kidney Disorders, Knock Out Mouse Model, Mouse Cell Lines, Mouse Model, Polycystic Kidney Disease

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Nephrology > Polycystic Kidney Disease, Technology Classifications > Diagnostics > Biomarkers

Early Diagnostic Biomarker for Acute Kidney Injury

C04756: Early Diagnostic Biomarker for Acute Kidney InjuryNovelty: Novel, early stage biomarker for easy diagnostic of acute kidney injury (AKI), acute renal failure (ARF) renal ischemia reperfusion injury, and/or ischemic acute tubular necrosis.Value Proposition: ARF is a syndrome with high mortality and morbidity, for which there is no specific therapy...

Published: 3/13/2025 | Inventor(s): Hamid Rabb

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Diagnostic Tool, Disease Indication, Kidney Disorders, Kidney Failure

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Nephrology > Kidney Failure, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Nephrology, Clinical and Disease Specializations > Nephrology > Renal Ischemia