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Methods for Payload and Size Characterization of Nucleic Acid Nanoparticles
Polymeric and lipid nanoparticles (NPs) are an effective and safe method for therapeutic delivery. At each of the various steps in nanoparticle development and manufacturing (i.e., research and design, quality assurance), assessing the features of these vehicles is essential. Some features (i.e., packaging characteristics, cargo location, structure...
Published: 3/14/2025
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Inventor(s):
Tza-Huei Wang
,
Hai-Quan Mao
,
Sixuan Li
,
Yizong Hu
,
Andrew Li
Keywords(s):
Category(s):
Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms
,
Technology Classifications > Research Tools > Imaging
,
Technology Classifications > Research Tools > Nucleic Acids
Scaly Aortic Stent Graft
Unmet NeedEvery year, around 200,000 people in the United States are diagnosed with an abdominal aortic aneurysm (AAA). Currently, a ruptured AAA is the 15th leading cause of death in the country. All techniques of repairing AAA utilize the addition of an aortic stent graft to fix the rupture. One of the newer techniques is to attach a graft after extending...
Published: 3/14/2025
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Inventor(s):
Andrew Schulick
,
Devika Singh
Keywords(s):
Cardiovascular Diseases
,
Disease Indication
,
Interventional and Surgical Systems
,
Stents
,
Surgical Instruments
,
Surgical Tubing
Category(s):
Technology Classifications > Medical Devices > Cardiology
,
Technology Classifications > Medical Devices > Surgical
,
Clinical and Disease Specializations > Cardiovascular
Smart Ankle Bracelet for Monitoring Limb Perfusion
Unmet NeedPerfusion is the method in which blood is delivered to tissue in animals. All animal tissues require adequate supplies of blood for sustained health and life. However, there are many surgeries and procedures that can decrease adequate perfusion. For example, critical limb ischemia (CLI), which affects more than 2 million people in the United...
Published: 3/14/2025
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Inventor(s):
Andrew Schulick
,
Luke Marone
Keywords(s):
Disease Indication
,
Orthotics
,
Skeletal Disorders
,
Therapeutic Devices
,
Therapeutics
Category(s):
Technology Classifications > Medical Devices > Orthopedic Devices
Rescue Thoracic Aortic Stent Graft
Unmet NeedThe Artery of Adamkewicz is the name of the dominant artery that supplies blood to the spinal cord. During thoracic aortic stent grafting, the artery can become occluded, leading to a multitude of complications, most commonly, paraplegia. When occlusion of the Artery of Adamkewicz occurs, the pathology is mediated by the covered stent exclusion...
Published: 3/14/2025
|
Inventor(s):
Andrew Schulick
,
Devika Singh
Keywords(s):
Cardiovascular Diseases
,
Disease Indication
,
Interventional and Surgical Systems
,
Stents
,
Surgical Instruments
,
Surgical Tubing
Category(s):
Technology Classifications > Medical Devices > Surgical
,
Clinical and Disease Specializations > Cardiovascular
Shingled Aortic Stent Graft
Unmet NeedAortic aneurysms were the cause of almost 10,000 deaths in 2017, and currently have an incidence of 10 cases per 100,000 in the United States. Aortic aneurysms that involve larger vessels pose extremely challenging problems for vascular surgeons. Almost all the vessels that branch out from the aneurysm will require revascularization, but it...
Published: 3/13/2025
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Inventor(s):
Andrew Schulick
,
Devika Singh
Keywords(s):
Cardiovascular Diseases
,
Disease Indication
,
Implanted Device
,
Implants
,
Stent
,
Therapeutic Devices
,
Therapeutics
Category(s):
Technology Classifications > Medical Devices > Cardiology
,
Technology Classifications > Medical Devices > Surgical
,
Clinical and Disease Specializations > Cardiovascular
Curved Angioplasty Balloon
Unmet NeedThe angioplasty of blood vessels is successfully completed in almost 90% of patients that require the procedure and is universally accepted as being an effective and durable method for restoring flow to occluded blood vessels. However, blood vessels are often always curved, yet commercial angioplasty balloons are manufactured only in straight...
Published: 3/13/2025
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Inventor(s):
Andrew Schulick
Keywords(s):
Balloons
,
Cardiovascular Diseases
,
Dilators/Retractors
,
Disease Indication
,
Interventional and Surgical Systems
,
Surgical Instruments
Category(s):
Technology Classifications > Medical Devices > Cardiology
,
Technology Classifications > Medical Devices > Surgical
,
Clinical and Disease Specializations > Cardiovascular
Magnetic Vascular Anastomosis to Connect Blood Vessels and Other Hollow Structures
Unmet NeedThere are around 600,000 vascular surgeries and 400,000 cardiac surgeries performed each year in the United States. Both types of surgeries rely on the ability of the surgeon to restore blood flow into blocked vessels. In open surgery, flow is usually re-established by bypassing the areas of blockage. Bypassing utilizes conduits that are comprised...
Published: 3/13/2025
|
Inventor(s):
Andrew Schulick
,
Devika Singh
Keywords(s):
Cardiovascular Diseases
,
Closure/Sealing Devices
,
Disease Indication
,
Interventional and Surgical Systems
,
Surgical Instruments
Category(s):
Technology Classifications > Medical Devices > Surgical
,
Clinical and Disease Specializations > Cardiovascular
Magnetic Catheter, Drain, and Tube Repositioning and Attachment Device
Unmet NeedThe use of peritoneal dialysis (PD) has increased by 30.3% in developed countries in the last 12 years. PD is usually used in the treatment of end stage renal disease (ESRD). Around 10% of ESRD patients undergo PD for renal replacement therapy. PD is administered through an indwelling catheter in the peritoneal cavity. Fluid is infused through...
Published: 3/13/2025
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Inventor(s):
Andrew Schulick
Keywords(s):
Catheters
,
Fixation Devices
,
Interventional and Surgical Systems
,
Surgical Instruments
,
Surgical Tubing
Category(s):
Technology Classifications > Medical Devices > Surgical
Breast Biopsy Needle Guide
Unmet NeedAround 250,000 patients are diagnosed with breast cancer each year, and overall, 1 in 8 women will be diagnosed with breast cancer in her lifetime. In order for proper diagnosis, biopsies must be performed, usually requiring minor, open surgery. The procedures commence with needle localization, where the radiologist inserts a needle into the...
Published: 3/13/2025
|
Inventor(s):
Andrew Schulick
,
Devika Singh
Keywords(s):
Category(s):
Technology Classifications > Medical Devices > Imaging
,
Technology Classifications > Diagnostics > In Vivo Diagnostics
,
Clinical and Disease Specializations > Oncology > Breast Cancer
,
Clinical and Disease Specializations > Women's Health
Targeted Compression Stockings
Unmet NeedMore than 23% of all adults are thought to be affected by varicose veins. These veins are enlarged and swollen as a result of faulty valves that allow blood to flow in the wrong direction. Currently, varicose veins are managed through the application of a compression garment such as a stocking. The garments help prevent veins from being engorged...
Published: 3/13/2025
|
Inventor(s):
Andrew Schulick
,
Devika Singh
Keywords(s):
Cardiovascular Diseases
,
Disease Indication
,
Other
,
Therapeutic Devices
,
Therapeutics
Category(s):
Technology Classifications > Medical Devices > Therapeutic Devices
,
Clinical and Disease Specializations > Cardiovascular
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