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Compositions of Kinetic Nanoparticles containing Nucleic Acids, Polycations, and Lipids with Defined Sizes, and Methods of Producing the Same

Value Proposition:· Scalable, efficient, and tunable nanoparticle creation technique that can deliver a variety of payloads· Polymer-lipid nanoparticles are biodegradable and are being tested for immunogenicity· Can be used for in vivo gene therapy delivery as well as in vitro cell transfection and research applications Technology...

Published: 6/28/2024 | Inventor(s): Hai-Quan Mao, Stephany Tzeng, Jordan Green, Yizong Hu, Sashank Reddy, Leonardo Cheng

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Methods for Payload and Size Characterization of Nucleic Acid Nanoparticles

Polymeric and lipid nanoparticles (NPs) are an effective and safe method for therapeutic delivery. At each of the various steps in nanoparticle development and manufacturing (i.e., research and design, quality assurance), assessing the features of these vehicles is essential. Some features (i.e., packaging characteristics, cargo location, structure...

Published: 6/28/2024 | Inventor(s): Tza-Huei Wang, Hai-Quan Mao, Sixuan Li, Yizong Hu, Andrew Li

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Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids

Composition of Shelf-stable Plasmid DNA/PEI Particles with Defined Sizes for Virus Production and Method for Preparation of the Same

Unmet NeedGene therapy has become increasingly popular for treating genetic and acquired diseases, with nearly 1000 ongoing clinical trials globally. These therapies are typically delivered via viral vectors, which are produced in vector production cell lines following transient transfection using nanoparticles such as those made of plasmid DNAs (pDNA)...

Published: 6/28/2024 | Inventor(s): Hai-Quan Mao, Yizong Hu, Yining Zhu

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Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies

Methods for Preparation of Shelf-stable Plasmid DNA/Polycation Particles with Defined Sizes for Cell Transfection

Published: 6/28/2024 | Inventor(s): Hai-Quan Mao, Yizong Hu, Yining Zhu

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Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies

Methods for Preparation of Plasmid DNA/Lipid Particles with Defined Size for in vitro and in vivo Transfection

Unmet NeedGene therapy has the potential to provide effective treatment options for a variety of monogenic human diseases [1].Viral-mediated gene therapy has seen some clinical success, including the recent FDA approval of therapeutics for retinal dystrophy and spinal muscular atrophy [2]. However, viral mediated therapies can have unwanted side effects,...

Published: 6/28/2024 | Inventor(s): Hai-Quan Mao, Yining Zhu, Yizong Hu

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Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Engineering Tech > Materials

Compositions and Method for Production of Size-Controlled Ternary Nanoparticles for Sustained Release of Peptide Therapeutics

Unmet NeedType 2 diabetes (T2D) contributes to 90% of all cases of diabetes and represents a critical global public health problem. T2D specifically affects glucose metabolism and those with the disease either do not produce enough insulin or do not respond properly to insulin signaling to maintain normal levels of glucose in the blood. Several serious...

Published: 6/28/2024 | Inventor(s): Hai-Quan Mao, Zhiyu He, Yizong Hu, Yongming Chen, Lixin Liu

Keywords(s): Biologics, Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Peptide, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Peptides, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Compositionally Defined Plasmid DNA/Polycation Nanoparticles and Methods for Making the Same

Unmet NeedGene therapy can be a cure-all for genetic disorders, and can be a promising therapy for diseases such as cancer, neurodegenerative diseases, neurological disorders, heart disease or diabetes. The success of gene therapy is dependent on the safety, efficacy, and specificity of the treatment. The delivery vehicle, also known as a vector, is...

Published: 6/28/2024 | Inventor(s): Hai-Quan Mao, Yizong Hu, Martin Pomper, Heng-wen Liu, Il Minn, Christopher Ullman, Christine Carrington

Keywords(s): Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Therapeutic Modalities > Gene Therapies, Clinical and Disease Specializations > Oncology