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Nanofiber Hydrogel Composite Gel to Prevent Scarring and Adhesion of Peripheral Nerves

JHU Ref #: [C17294] Value Proposition:· Application of composite hydrogel to mechanically irritated nerves can reduce perineural adhesions and scar formation.· Improves patient outcomes following peripheral nerve surgery. Technology Description· Researchers at Johns Hopkins have developed a nanofiber-hydrogel composite (NHC) material...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Sashank Reddy, Visakha Suresh, Thomas Harris, Chenhu Qiu

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Medical Devices > Plastic Surgery, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Compositions of Lipid Nanoparticles for Plasmid DNA Delivery to the Liver and Methods for Preparing the Same

Value Proposition:· Library screen of lipid nanoparticles to develop compositions for efficient transfection and tissue-specific delivery.· Selected high efficiency lipid nanoparticles for delivering plasmid DNA, siRNA, and mRNA. Technology Description· Researchers at Johns Hopkins have developed a multi-step screening method to...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Sashank Reddy, Ruochen Shen, Ivan Vuong, Jingyao Ma, Leonardo Cheng

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Polymeric Nanoparticle Compositions for Encapsulation and Sustained Release of Neuromodulators

JHU Ref #: C16591Value Proposition· Protein delivery system with tunable, sustained release profile, high payload capacity, and bioactivity retention· Neurotoxin release profile of at least 120 days· Scalable and translational manufacturing processUnmet Need· Neurotoxins are widely used in the aesthetic and therapeutic space. Among...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Sashank Reddy, Chenhu Qiu

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Therapeutic Modalities

Compositions of Kinetic Nanoparticles containing Nucleic Acids, Polycations, and Lipids with Defined Sizes, and Methods of Producing the Same

Value Proposition:· Scalable, efficient, and tunable nanoparticle creation technique that can deliver a variety of payloads· Polymer-lipid nanoparticles are biodegradable and are being tested for immunogenicity· Can be used for in vivo gene therapy delivery as well as in vitro cell transfection and research applications Technology...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Stephany Tzeng, Jordan Green, Yizong Hu, Sashank Reddy, Leonardo Cheng

Keywords(s):

Nanoparticle Compositions for Sustained Delivery of Pro-regenerative Growth Factors for Nerve Repair, Preparation Processes of the Same, and Treatment Methods Using the Same

Unmet NeedGlobal incidence rates for peripheral nerve injury (PNI) are not well aggregated. However, US data collected shows that 20 million Americans suffer from peripheral nerve injury caused by trauma and medical disorders. [16] When a tension-free early repair is possible, microsurgical direct nerve repair with epineural sutures remains the gold...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Chenhu Qiu, Sashank Reddy, Yicheng Zhang, Thomas Harris, Philip Hanwright, Karim Sarhane, Nicholas von Guionneau, Erica Lee

Keywords(s):

Category(s): Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

COMPOSITIONS AND METHODS FOR PREPARATION OF COMPOSITE POLYMER FILMS ON NON-CONDUCTING SUBSTRATES, INCLUDING BANDAGES, AND THEIR USE FOR TREATING WOUNDS

Technology DescriptionResearchers at Johns Hopkins have developed a polymer film coating for bandages and/or medical devices. treating or preventing infections. The coating can be used to delivery drugs for the treatment or prevention of infections, as the material can be synthesized to include several bioactive agents immobilized in such a way that...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Lloyd Miller, Alyssa Ashbaugh, Xuesong Jiang, Jesse Zheng, Sashank Reddy, Bartlomiej Kachniarz

Keywords(s): Bacterial Infections, Disease Indication, Drug Delivery Device, Implanted Device, Implants, Infectious Diseases, Medical Devices, Therapeutic Devices

Category(s): Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Polymeric Nanoparticle Compositions for Encapsulation and Sustained Release of Protein Therapeutics and Methods for Scalable Production of the Same

JHU Ref #: C14938Value Proposition· Biodegradable nanoparticle composition with core-shell structure· Controllable nanoparticle size with low polydispersity index· Wide range for protein loading level· Nanoparticles capable of sustained released over period of 2 weeks to 3 monthsUnmet Need· Protein therapeutics are used for...

Published: 3/13/2025 | Inventor(s): Hai-Quan Mao, Sashank Reddy, Xiyu Ke, Chenhu Qiu, Daniel Lucena Domingues, Gregory Howard

Keywords(s): Drug Delivery Vehicle, Drug Delivery Vehicle Synthesis Method, Nanoparticles, Therapeutic Matter, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers