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A mRNA Lipid Nanoparticle Incorporated Nanofiber-hydrogel Composite to Generate a Local Immunostimulatory Niche for Immunotherapy

Value Proposition:· Creates a programmable immunostimulatory niche.· Allows for tailor-made immune responses to vaccines and antigens.· Flexible drug delivery platform enables mRNA therapeutics for infectious diseases and cancers.· Applicable to existing mRNA vaccines for improved efficacy. · Can be utilized for novel...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Zhicheng Yao, Christine Wei

Keywords(s):

Category(s): Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Research Tools > Microfluidics

Composition of Media with Defined Fluid Viscosity for Enhancing Intracellular Delivery of Nanoparticles and Viral Vectors, and Methods of Use

Unmet Need· Production of gene therapies, cell therapies, and recombinant proteins are largely dependent on efficient transfection using viral vectors or nanoparticle vehicles to deliver genetic cargo. However, although numerous transfection reagents have been developed, many strategies still suffer from low efficiency in particular cell-lines...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Sean Sun, Zhuoxu Ge, Qin Ni

Keywords(s):

Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Viruses, Technology Classifications > Research Tools > Nucleic Acids

Compositions of Lipid Nanoparticles for Plasmid DNA Delivery to the Liver and Methods for Preparing the Same

Value Proposition:· Library screen of lipid nanoparticles to develop compositions for efficient transfection and tissue-specific delivery.· Selected high efficiency lipid nanoparticles for delivering plasmid DNA, siRNA, and mRNA. Technology Description· Researchers at Johns Hopkins have developed a multi-step screening method to...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Sashank Reddy, Ruochen Shen, Ivan Vuong, Jingyao Ma, Leonardo Cheng

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Composition of Shelf-stable Plasmid DNA/PEI Particles with Defined Sizes for Virus Production and Method for Preparation of the Same

Unmet NeedGene therapy has become increasingly popular for treating genetic and acquired diseases, with nearly 1000 ongoing clinical trials globally. These therapies are typically delivered via viral vectors, which are produced in vector production cell lines following transient transfection using nanoparticles such as those made of plasmid DNAs (pDNA)...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Yizong Hu, Yining Zhu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies

Methods for Preparation of Shelf-stable Plasmid DNA/Polycation Particles with Defined Sizes for Cell Transfection

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Yizong Hu, Yining Zhu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Gene Therapies

Methods for Preparation of Plasmid DNA/Lipid Particles with Defined Size for in vitro and in vivo Transfection

Unmet NeedGene therapy has the potential to provide effective treatment options for a variety of monogenic human diseases [1].Viral-mediated gene therapy has seen some clinical success, including the recent FDA approval of therapeutics for retinal dystrophy and spinal muscular atrophy [2]. However, viral mediated therapies can have unwanted side effects,...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Yizong Hu

Keywords(s):

Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Engineering Tech > Materials