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Compositions of Lipid Nanoparticles for Plasmid DNA Delivery to the Liver and Methods for Preparing the Same

Value Proposition:· Library screen of lipid nanoparticles to develop compositions for efficient transfection and tissue-specific delivery.· Selected high efficiency lipid nanoparticles for delivering plasmid DNA, siRNA, and mRNA. Technology Description· Researchers at Johns Hopkins have developed a multi-step screening method to...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Yining Zhu, Sashank Reddy, Ruochen Shen, Ivan Vuong, Jingyao Ma, Leonardo Cheng

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Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Compositions of Kinetic Nanoparticles containing Nucleic Acids, Polycations, and Lipids with Defined Sizes, and Methods of Producing the Same

Value Proposition:· Scalable, efficient, and tunable nanoparticle creation technique that can deliver a variety of payloads· Polymer-lipid nanoparticles are biodegradable and are being tested for immunogenicity· Can be used for in vivo gene therapy delivery as well as in vitro cell transfection and research applications Technology...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Stephany Tzeng, Jordan Green, Yizong Hu, Sashank Reddy, Leonardo Cheng

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System and Method for Phase Dependent Brain Neuromodulation

Unmet Need Neuromodulation is a technology that involves the spatiotemporal alteration of brain activity with electrical, magnetic, or chemical stimulation. Neuromodulation devices can be implantable or non-implantable and target specific areas of the body in order to restore proper activity to a malfunctioning nervous system most commonly...

Published: 3/13/2025 | Inventor(s): William Anderson, Yousef Salimpour, Leon Chen, Kelly Mills

Keywords(s): Brain Stimulation, CNS and Neurological Disorders, Disease Indication, Implanted Device, Implants, Interventional and Surgical Systems, Neuromodulator, Surgical Intervention Method, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices > Neurostimulation, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices