Search Results - hai-quan+mao

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Sutureless Adhesive Connectors for Tissue Repair

Value Proposition· Eliminates the need for time-consuming microsurgical sutures for tubular organ repair, reducing operative time and anesthesia exposure.· Minimizes additional tissue trauma caused by suturing, improving functional recovery and reducing complications.· Uses biodegradable materials and engineered adhesives/nanostructures...

Published: 4/23/2026 | Inventor(s): Hai-Quan Mao, Ahmet Hoke

Keywords(s): Disease Indication, Implanted Device, Implants, Therapeutic Devices, Therapeutics, Tissue Engineering/Regenerative Devices, Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices

Long Term Storage and Improved Mechanical Properties of Implantable Vascular Grafts

Technical ProblemCurrent synthetic small-diameter tissue engineered vascular grafts face challenges such as thrombogenicity, decreased elasticity, aneurysmal failure, calcification, and intimal hyperplasia, limiting their clinical effectiveness for pediatric congenital cardiovascular defects, coronary artery disease, and peripheral artery disease, while...

Published: 4/24/2026 | Inventor(s): Sharon Gerecht, Morgan Elliott, Hai-Quan Mao, Jessica Shen

Keywords(s):

Category(s): Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Therapeutic Modalities > Tissue Substrates, Technology Classifications > Medical Devices > Cardiology

Lipid Nanoparticle Formulations Capable of Migrating to Systemic Organs Following Intramuscular Administration

Value Proposition:Organ-targeted drug or mRNA delivery to focus therapy on specific tissues. Accessible intramuscular administration, offering broadly applicable, out-of-the-box drug delivery system for a range of therapeutics.Achieves organ-specific delivery without antibodies or targeting ligands, simplifying manufacturing and scalability.Unmet NeedTargeting...

Published: 4/24/2026 | Inventor(s): Hai-Quan Mao, Yining Zhu, Christine Wei, Di Yu

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Category(s): Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Nanofiber Nerve Cuffs to Inhibit Neuroma Formation

JHU Ref #: C17593Value Proposition:· This device can be used to cap the end of a severed nerve to prevent unwanted nerve growth through a combination of physical and biochemical mechanisms.· This device is more effective than existing nerve caps and cuffs, due to the inclusion of bioactive agents that biochemically influence nerve growth.Technology...

Published: 4/24/2026 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Ahmet Hoke, Anson Zhou, Bruce Enzmann, Michael Lan, Erica Lee, Ruifa Mi, Russell Martin

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Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices, Technology Classifications > Medical Devices > Therapeutic Devices

Biodegradable Nanofiber Conical Conduits for Targeted Muscle Reinnervation

Unmet NeedThere are 2 million amputees in the United States, with limb loss attributed to diabetes mellitus, vascular disease, trauma, and malignancy of bone and joints (Amputee Coalition, 2021 and Ziegler-Graham, et al., 2008). Living with an amputation and the adoption of assistive devices like prosthetics can be challenging, with chronic pain especially...

Published: 4/24/2026 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Ahmet Hoke, Michael Lan, Bruce Enzmann, Anson Zhou, Alison Wong, Erica Lee, Sai Pinni

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Category(s): Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Orthopedic Devices

A mRNA Lipid Nanoparticle Incorporated Nanofiber-hydrogel Composite to Generate a Local Immunostimulatory Niche for Immunotherapy

Value Proposition:· Creates a programmable immunostimulatory niche.· Allows for tailor-made immune responses to vaccines and antigens.· Flexible drug delivery platform enables mRNA therapeutics for infectious diseases and cancers.· Applicable to existing mRNA vaccines for improved efficacy. · Can be utilized for novel...

Published: 4/24/2026 | Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Zhicheng Yao, Christine Wei

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Category(s): Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Research Tools, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines, Technology Classifications > Research Tools > Microfluidics

Enhancing Cell Transfection Through Viscosity-Increasing Agents

Unmet Need· Production of gene therapies, cell therapies, and recombinant proteins are largely dependent on efficient transfection using viral vectors or nanoparticle vehicles to deliver genetic cargo. However, although numerous transfection reagents have been developed, many strategies still suffer from low efficiency in particular cell-lines...

Published: 4/24/2026 | Inventor(s): Hai-Quan Mao, Yining Zhu, Jingyao Ma, Sean Sun, Zhuoxu Ge, Qin Ni

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Category(s): Technology Classifications > Research Tools > Buffers & Media Solutions, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Viruses, Technology Classifications > Research Tools > Nucleic Acids

Kinetically controlled methods to prepare concentrated shelf-stable nucleic acid transfection vehicles

Value Proposition:· Technology creates particles optimally size for use as vehicles for cell transfection.· The reagents and processes for particle creation are kinetically controlled and reproducible.· Cationic particles created using these methods can carry larger payloads than current vehicles.· Reagents and nucleic acid-loaded...

Published: 4/24/2026 | Inventor(s): Hai-Quan Mao, Yizong Hu, Jinghan Lin

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Composite Hydrogel that Prevents Post-Surgical Nerve Damage

JHU Ref #: [C17294] Value Proposition:· Application of composite hydrogel to mechanically irritated nerves can reduce perineural adhesions and scar formation.· Improves patient outcomes following peripheral nerve surgery. Technology Description· Researchers at Johns Hopkins have developed a nanofiber-hydrogel composite (NHC) material...

Published: 4/24/2026 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Sashank Reddy, Visakha Suresh, Thomas Harris, Chenhu Qiu

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Category(s): Technology Classifications, Technology Classifications > Medical Devices > Plastic Surgery, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Compositions of Lipid Nanoparticles for Plasmid DNA Delivery to the Liver and Methods for Preparing the Same

Value Proposition:· Library screen of lipid nanoparticles to develop compositions for efficient transfection and tissue-specific delivery.· Selected high efficiency lipid nanoparticles for delivering plasmid DNA, siRNA, and mRNA. Technology Description· Researchers at Johns Hopkins have developed a multi-step screening method to...

Published: 4/24/2026 | Inventor(s): Hai-Quan Mao, Yining Zhu, Sashank Reddy, Ruochen Shen, Ivan Vuong, Jingyao Ma, Leonardo Cheng

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Category(s): Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

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