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Methods for in situ Detection of DNA Sequence Variation

Value Proposition· High-throughput· Assess genetic variants with simultaneous spatial analysis· Interrogate over 100 variants in a single assayUnmet Need· Next generation sequencing has led to an ever-proliferating dearth of genetic information. More recent progress in nucleoside tissue analysis has birthed the field of spatial...

Published: 3/14/2025 | Inventor(s): Reza Kalhor, Soichiro Asami

Keywords(s):

Category(s): Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Bioinformatics, Technology Classifications > Research Tools > Imaging, Technology Classifications > Research Tools > Nucleic Acids

Nanofiber Hydrogel Composite Gel to Prevent Scarring and Adhesion of Peripheral Nerves

JHU Ref #: [C17294] Value Proposition:· Application of composite hydrogel to mechanically irritated nerves can reduce perineural adhesions and scar formation.· Improves patient outcomes following peripheral nerve surgery. Technology Description· Researchers at Johns Hopkins have developed a nanofiber-hydrogel composite (NHC) material...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Sami Tuffaha, Sashank Reddy, Visakha Suresh, Thomas Harris, Chenhu Qiu

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Medical Devices > Plastic Surgery, Technology Classifications > Medical Devices > Regenerative Medicine, Technology Classifications > Medical Devices > Surgery, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Engineering Tech > Materials, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Dendrimers & Polymers

Polymeric Nanoparticle Compositions for Encapsulation and Sustained Release of Neuromodulators

JHU Ref #: C16591Value Proposition· Protein delivery system with tunable, sustained release profile, high payload capacity, and bioactivity retention· Neurotoxin release profile of at least 120 days· Scalable and translational manufacturing processUnmet Need· Neurotoxins are widely used in the aesthetic and therapeutic space. Among...

Published: 3/14/2025 | Inventor(s): Hai-Quan Mao, Sashank Reddy, Chenhu Qiu

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Therapeutic Modalities

Combination therapy targets intrinsic cancer resistance to nucleoside DNA methyltransferase inhibitors.

Unmet NeedGenome stability is regulated by a variety of mechanisms. One such mechanism is DNA methylation. DNA methylation can alter the manner in which genes are expressed, and aberrations in methylation management are well documented as features of cancer cells. DNA methylation is regulated in part by enzymes known as DNA methyltransferases (DNMTs)....

Published: 3/14/2025 | Inventor(s): Srinivasan Yegnasubramanian, Jianyong Liu, William Nelson, Jun Liu

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications, Technology Classifications > Therapeutic Modalities > Small Molecules

18F-Labeled PET Radiotracers for Imaging Neuroinflammation in the Brain

Value Proposition:· Quantification and PET imaging of microglial cells in the brain· Diagnostic for neuroinflammatory disorders – Alzheimer’s and MS· Favorable compound half-life enables shipping· Potential for non-CNS applications Technology DescriptionResearchers at Johns Hopkins have developed a series of Positron Emission Tomography...

Published: 3/14/2025 | Inventor(s): Martin Pomper, Deepankar Das, Andrew Horti, Wojciech Lesniak

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Imaging

Recombinant anti-PAD4 antibodies as a treatment for lung fibrosis

Value PropositionSelective monoclonal antibody therapy to treat lung fibrosis.Directly targets immune cells to promote a pro-inflammatory pathway that reduces fibrosis.High serum levels are associated with less severe lung disease, decreased fibrosis, and improved survival in a subset of rheumatoid arthritis patients.Broadly applicable to other diseases...

Published: 3/14/2025 | Inventor(s): Erika Darrah, Felipe Andrade, Kristen Demoruelle, Elizabeth Redente

Keywords(s):

Category(s): Clinical and Disease Specializations > Fibrosis, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications, Technology Classifications > Therapeutic Modalities

Col3a1G938D heterozygous mice

Unmet Need:Vascular Ehlers-Danlos syndrome (vEDS) is a rare genetic connective tissue disorder. Patients with vEDS present with thin, translucent skin, easy bruising, and a characteristic facial appearance. Most critically, they are at risk for spontaneous rupture of the major arteries, hollow organs, and gravid uterus. Preclinical investigation of...

Published: 3/14/2025 | Inventor(s): Harry Dietz, Caitlin Bowen

Keywords(s):

Category(s): Clinical and Disease Specializations > Genetic Diseases, Technology Classifications, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

DOPA and Caffeic Acid Analogs as Novel GCPII Inhibitors

Unmet NeedGlutamate is the primary excitatory neurotransmitter in the human brain [1]. Excessive glutamate signaling can disrupt calcium homeostasis, leading to mitochondrial dysfunction, the overproduction of reactive oxygen species, and neuron loss via necrotic or apoptotic pathways [2]. This phenomenon, known as excitotoxicity, contributes to disease...

Published: 3/14/2025 | Inventor(s): Barbara Slusher, Rana Rais, Takashi Tsukamoto

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Small Molecules

Photoacoustic Tumor Bed Imaging in Breast Conserving Surgery

Method for identifying residual breast cancer cells following tumor removalJHU Ref #: C17840Value Proposition· Enables medical professionals to identify residual tumor cells for removal in real-time· Reduces time and cost by eliminating need for post-operative analysis of excised tissue· Safe and radiation-free alternative to other...

Published: 3/14/2025 | Inventor(s): Emad Boctor, Russell Taylor, Laura Connolly, Gabor Fichtinger, Parvin Mousavi

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications, Technology Classifications > Medical Devices > Imaging

Multi-Compartment Fallopian Tube Organoid Model

Unmet Need: Existing organoid models of the fallopian tube are architecturally simplified compared to the intricate epithelial-lumen interface in scale and structure, and there remains a need in the art for multi-compartment fallopian tube organoids that architecturally simulate the intricate architecture of the epithelial-lumen interface in structural...

Published: 3/14/2025 | Inventor(s): Meng Horng Lee, Gabriella Russo, Denis Wirtz, Ashleigh Crawford, Wenxuan Du

Keywords(s):

Category(s): Technology Classifications, Technology Classifications > Medical Devices, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Stem Cells, Technology Classifications > Research Tools > Microfluidics, Clinical and Disease Specializations > Oncology

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