Search Results - saraswati+sukumar

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Identification and testing of novel methylated markers that distinguish between primary diffuse large B-cell lymphoma of the central nervous system (DBCL-CNS) and other tumors of the CNS

C16190: Identification and testing of novel methylated markers that distinguish between primary diffuse large B-cell lymphoma of the central nervous system (DBCL-CNS) and other tumors of the CNS Inventors: Saraswati Sukumar, Bradley Downs, Wanjun Ding Unmet NeedGlobally, approximately 300,000 brain cancers are diagnosed each year, which results in about...

Published: 3/14/2025 | Inventor(s): Bradley Downs, Saraswati Sukumar, Wanjun Ding, WeiPing Tao

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers

Novel biomarker discovery program to identify methylation markers in cancer

Unmet Need / Invention Novelty: Methylation arrays can be used to identify methylation biomarkers in cancer for development as methylation-specific PCR diagnostic assays. However, existing array data analysis is manually intensive. There is an unmet need to develop a new data analysis tools to identify methylation biomarkers in cancer. Technical Details:...

Published: 3/14/2025 | Inventor(s): Saraswati Sukumar, Bradley Downs

Keywords(s):

Category(s): Copyright, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations, Technology Classifications, Technology Classifications > Diagnostics

Detection of circulating methylated DNA for high-sensitivity cancer diagnostic and treatment planning

Unmet Need / Invention Novelty: Circulating tumor-associated methylated DNA is an important biomarker for early detection of cancer, risk assessment, predicting and monitoring response to therapy and early detection of relapse. Current tests designed to detect methylated tumor DNA in patient fluids such as the serum and plasma are challenged by low...

Published: 3/13/2025 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Antonio Wolff, Zoila Lopez Bujanda, Wei Wen Teo

Keywords(s): Assay, Clinical Diagnostics, In Vitro Diagnostics

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Methylation Markers that Provide Molecular Diagnosis by Distinguishing Between Benign from Malignant Breast Cancer and Predict Risk

Unmet NeedBreast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in low and middle income countries (LMICs), and is expected to increase in incidence due to longer life expectancies, decreased burden of infectious diseases, and changes in reproductive risk factors. In LMICs, breast cancer mortality rates are as high...

Published: 3/13/2025 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Bradley Downs

Keywords(s): Assay, Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Therapeutic Matter, Therapeutics

Novel Biomarker for Breast Cancer Detection Outcome and Treatment Sensitization to Nucleolin and CDK Inhibitors

Unmet Need: Despite widespread research efforts, breast cancer remains the second leading cause of cancer deaths in women. There is an urgent need to identify novel biomarkers and treatment strategies against aggressive forms of breast cancer to improve prognosis and therapy. Technical Details: Johns Hopkins researchers have identified a novel biomarker...

Published: 3/14/2025 | Inventor(s): Vanessa Merino, Saraswati Sukumar, Martin Pomper

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prognostic Biomarker, Prostate Cancer

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Therapeutic Modalities > Targets

Methylation markers for stratifying breast cancer, for prognosis, for predicting disease recurrence and response to treatment

C11625: Markers to Differentiate between ER Subtypes, Predict Treatment Outcome and Risk of Reoccurrence in Breast Cancer Value Proposition: - 40 loci have been validated in an independent dataset. - This technology may reveal important biological differences in the epigenome between breast cancer subtypes. - These markers may provide ancillary clinical...

Published: 3/13/2025 | Inventor(s): Mary jo Fackler, Leslie Cope, Antonio Wolff, Peng Huang, Zhe Zhang, Christopher Umbricht, Kala Visvanathan, Saraswati Sukumar

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Pharmakodynamic Biomarker, Prognostic Biomarker, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

PIK3CA Mutants Transgenic Mouse

C11063: PIK3CA Mutants Transgenic Mouse Technical Details: BACKGROUND Transgenic animals are currently produced as disease models to exhibit disease symptoms so that effective treatment can be studied TECHNOLOGY JHU researchers have generated transgenic mice expressing the hot spot mutations for PI3KCA (H1047R and E545K) specifically in mammary...

Published: 3/13/2025 | Inventor(s): Vanessa Merino, Xiaohui Liang, Saraswati Sukumar

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, In Vivo Research Tool, Mouse Cell Lines, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Forkhead box-F (FOXF) Genes are Novel Negative Regulators of DNA Replication and are Epigenetically Silenced in Breast Cancer

C10643: Expression plasmids for HA-tagged FOXFl and HA-tagged FOXF2Value Proposition: Technical Details: JHU scientists have developed HA-tagged FOXFl and HA-tagged FOXF2 expression plasmids. Full-length cDNAs for FOXF genes were isolated by using RT-PCR of RNA from normal mammary organoids and cloned them into pGEM-T-Easy vector (Promega). After sequencing...

Published: 3/13/2025 | Inventor(s): Pang-Kuo Lo, Saraswati Sukumar

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Cloning Reagents, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Plasmid, Research Reagent, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

J HIN, J RASSF1A, J TWIST, J HIC Plasmids

C10434: Reagents for gene methylation assays. Technical Details: Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfate treatment. The plasmids contain sequences hybridizing to external QM-MSP regions within gene promoters of RASSF1A, TWIST1, NIN1, and HIC1. These areas bracket cloned DNA from non-human sources...

Published: 3/13/2025 | Inventor(s): Mary jo Fackler, Saraswati Sukumar

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

ER alpha M4, ER alpha U4, p16 M4, p16 U5, Hin1 M1, Hin1 U2, RASSF1a M1, RASSF1a U1, RAR beta M1, RAR beta U1, Twist BM2, Twist BU5, APC M3, APC U3, Cylin D2 M1, Cyclin D2 U4, 14-3-3 M2, 14-3-3 U3, HIC1 M1, and HIC1 U3 plasmids

C10165: Reagents, standards, or controls for assays of gene methylation. Technical Details: Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfite treatment.Looking for Partners: Their use includes serving as reagents, standards, or controls for assays of gene methylation (e.g. for determining Methylated or unmethylated...

Published: 3/13/2025 | Inventor(s): Mary jo Fackler, Saraswati Sukumar

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

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