Search Results - christopher+umbricht

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Unmet NeedThyroid cancer is the most common malignancy of the endocrine system, representing 2.9% of all new cancer cases in the United States and is the fifth most common cancer in women. Every year, about 12,000 men and 35,000 women are diagnosed with thyroid cancer, and more than 900 men and 1,100 women die from the disease. Although fine needle...

Published: 7/5/2024 | Inventor(s): Christopher Umbricht, Yongchun Wang, Martha Zeiger

Keywords(s):

Category(s): Technology Classifications > Diagnostics > Biomarkers, Clinical and Disease Specializations > Oncology > Thyroid Cancer

Epicopy, a Statistical Method to Identify Genomic Copy Number Variation (CNV) using High-density DNA Methylation Arrays

Genetic and epigenetic alterations have been implicated in carcinogenesis and integrated analyses of these have provided new insights into the mechanisms of cancer development. We developed Epicopy, a statistical method to identify copy number variation (CNV) using high-density Illumina 450K methylation arrays. Using Epicopy, we studied the instances...

Published: 7/4/2024 | Inventor(s): Christopher Umbricht, Leslie Cope, Soonweng Cho, Hyun-Seok Kim

Keywords(s): Cancers, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Disease Indication, Physics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software

Methylation markers for stratifying breast cancer, for prognosis, for predicting disease recurrence and response to treatment

C11625: Markers to Differentiate between ER Subtypes, Predict Treatment Outcome and Risk of Reoccurrence in Breast Cancer Value Proposition: - 40 loci have been validated in an independent dataset. - This technology may reveal important biological differences in the epigenome between breast cancer subtypes. - These markers may provide ancillary clinical...

Published: 7/4/2024 | Inventor(s): Mary jo Fackler, Leslie Cope, Antonio Wolff, Peng Huang, Zhe Zhang, Christopher Umbricht, Kala Visvanathan, Saraswati Sukumar

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Pharmakodynamic Biomarker, Prognostic Biomarker, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

Seventy Two Gene Model for 8 Thyroid Tumor Types

C10073: Seventy Two Gene Model for 8 Thyroid Tumor Types Value Proposition: Thyroid cancer represents 90% of all neuroendocrine malignancies with an estimated annual incidence of 122,800 cases worldwide. Currently, the most useful tool for the diagnosis of thyroid cancer is Fine-needle aspiration biopsy (FNA). This current method is extremely useful...

Published: 7/4/2024 | Inventor(s): Steven Libutti, Martha Zeiger, Nijaguna Prasad, Christopher Umbricht

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Thyroid Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Endocrinology, Clinical and Disease Specializations > Oncology > Thyroid Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase (hTERT) in Thyroid Tumors Distinguish Benign from Malignant

C05018: Alternative Splice Variant Patterns of Human Telomerase Reverse Transcriptase (hTERT) in Thyroid Tumors Distinguish Benign from Malignant Technical Details: Human telomerase reverse transcriptase (hTERT) is activated in thyroid cancer. Despite this, its usefulness as a marker in the distinction of benign from malignant neoplasm has not been...

Published: 7/4/2024 | Inventor(s): Yongchun Wang, Christopher Umbricht, Jeanne Kowalski, Martha Zeiger

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Thyroid Cancer

Diagnostic Tool for Diagnosing Benign Versus Malignant Thyroid Lesions

C04567: Diagnostic Tool for Diagnosing Benign Versus Malignant Thyroid Lesions Technical Details: Thyroid cancer represents 1% of all malignant diseases and it is estimated that 5-10% of the population will develop a clinically significant thyroid nodule during their lifetime. The best available test for thyroid nodule is fine needle aspiration biopsy...

Published: 7/4/2024 | Inventor(s): Steven Libutti, Chiara Mazzanti, Christopher Umbricht, Martha Zeiger

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Thyroid Cancer