Search Results - leslie+cope

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Epicopy, a Statistical Method to Identify Genomic Copy Number Variation (CNV) using High-density DNA Methylation Arrays

Genetic and epigenetic alterations have been implicated in carcinogenesis and integrated analyses of these have provided new insights into the mechanisms of cancer development. We developed Epicopy, a statistical method to identify copy number variation (CNV) using high-density Illumina 450K methylation arrays. Using Epicopy, we studied the instances...

Published: 10/4/2024 | Inventor(s): Christopher Umbricht, Leslie Cope, Soonweng Cho, Hyun-Seok Kim

Keywords(s): Cancers, Computer Systems Based on Biological Models, Computer Systems Based on Specific Computational Models, Computing; Calculating; Counting, Disease Indication, Physics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software

Gene silencing technology for the treatment of triple negative breast cancer

Invention Novelty: The given invention proposes an efficient technology for the treatment of triple negative breast cancer Value Proposition: Often associated with rapid progression and poor outcomes, Triple Negative Breast Cancer (TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR)...

Published: 10/3/2024 | Inventor(s): Leslie Cope, David Huso, Linda Smith Resar

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Methylation markers for stratifying breast cancer, for prognosis, for predicting disease recurrence and response to treatment

C11625: Markers to Differentiate between ER Subtypes, Predict Treatment Outcome and Risk of Reoccurrence in Breast Cancer Value Proposition: - 40 loci have been validated in an independent dataset. - This technology may reveal important biological differences in the epigenome between breast cancer subtypes. - These markers may provide ancillary clinical...

Published: 10/3/2024 | Inventor(s): Mary jo Fackler, Leslie Cope, Antonio Wolff, Peng Huang, Zhe Zhang, Christopher Umbricht, Kala Visvanathan, Saraswati Sukumar

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Pharmakodynamic Biomarker, Prognostic Biomarker, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology