Search Results - breast+cancer

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Methylation Markers that Provide Molecular Diagnosis by Distinguishing Between Benign from Malignant Breast Cancer and Predict Risk

Unmet NeedBreast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in low and middle income countries (LMICs), and is expected to increase in incidence due to longer life expectancies, decreased burden of infectious diseases, and changes in reproductive risk factors. In LMICs, breast cancer mortality rates are as high...

Published: 3/13/2025 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Bradley Downs

Keywords(s): Assay, Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Therapeutic Matter, Therapeutics

Novel Biomarker for Breast Cancer Detection Outcome and Treatment Sensitization to Nucleolin and CDK Inhibitors

Unmet Need: Despite widespread research efforts, breast cancer remains the second leading cause of cancer deaths in women. There is an urgent need to identify novel biomarkers and treatment strategies against aggressive forms of breast cancer to improve prognosis and therapy. Technical Details: Johns Hopkins researchers have identified a novel biomarker...

Published: 3/14/2025 | Inventor(s): Vanessa Merino, Saraswati Sukumar, Martin Pomper

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics (Old), Prognostic Biomarker, Prostate Cancer

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Therapeutic Modalities > Targets

GATA3 wild type MCF-7 breast cancer cells GATA3 D336fs*17 mutant CAMA1 breast cancer cells

Unmet NeedMutations in the transcription factor-encoding gene GATA3 are highly prevalent in breast cancer but the functional role of mutant GATA3 in malignancy remains unclear due in part to the absence of appropriate research tools. Human breast cancer cell lines with mutant and wild-type GATA3, including MCF-7 and CAMA1, respectively, are commercially...

Published: 3/13/2025 | Inventor(s): Josh Lauring, John Gustin

Keywords(s): Basic Research Biomarker, Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Research Tools > Cell Lines

HER2-positive breast cancer cell lines derived from transgenic HuHER2 mouse model

Unmet NeedPreclinical evaluation of therapeutic agents against metastatic breast cancer require cell lines and animal models that recapitulate clinical metastatic breast cancer.Technology OverviewResearchers at Johns Hopkins University extracted primary mammary gland tumors, purified the epithelial breast cancer cells over a number of passages, and...

Published: 3/13/2025 | Inventor(s): George Sgouros, Sunju Park

Keywords(s): Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Unique Organ-specific Metastatic Human Breast Cancer Cell Lines

TITLEUnique organ-specific metastatic human breast cancer cell lines CASE NUMBERC13010 ABSTRACTA history of clinical observations has demonstrated that breast cancer metastases are capable of sustained deadly growth in several vital organs, such as, lung, brain, and liver as well as bone/marrow, ovaries, adrenals, lymph nodes, and skin. In order to...

Published: 3/13/2025 | Inventor(s): Venu Raman, Paul Winnard

Keywords(s): Breast Cancer, Cancer Cells, Cancers, Cell Lines, Cell Model, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Giant Obscurins: Novel Tumor and Metastasis Suppressors in Breast Cancer with Prognostic and Therapeutic Potentials

Provided herein are methods and kits for evaluating potential for invasiveness, metastasis, or recurrence of an epithelial cell cancer. In the methods the expression profile of giant obscurins is detected in a tissue sample of tumor cells or suspected tumor cells and assessed for giant obscuring expression level and distribution therein. Decreased levels...

Published: 3/13/2025 | Inventor(s): Nicole Perry, Marey Shriver, Aikaterini Kontrogianni-Konstantopou, Konstantinos Konstantopoulos

Keywords(s): Biologics, Breast Cancer, Cancers, Disease Indication, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Functional Analysis of Non-amplified/overexpressed HER2 L869R Heterozygous in Human Somatic Breast Cells

TITLE Functional analysis of non-amplified/overexpressed HER2 L869R heterozygous in human somatic breast cellsJHU Ref. #C13782ABSTRACTHuman epidermal growth factor receptor 2 (HER2) missense mutations have been reported in human cancers and primarily occur in the absence of HER2 gene amplification. Whether...

Published: 3/13/2025 | Inventor(s): Ben Ho Park, Daniel Zabransky, Sarah Croessmann

Keywords(s): Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Gene silencing technology for the treatment of triple negative breast cancer

Invention Novelty: The given invention proposes an efficient technology for the treatment of triple negative breast cancer Value Proposition: Often associated with rapid progression and poor outcomes, Triple Negative Breast Cancer (TNBC) refers to any breast cancer that does not express the genes for estrogen receptor (ER), progesterone receptor (PR)...

Published: 3/13/2025 | Inventor(s): Leslie Cope, David Huso, Linda Smith Resar

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Overexpression of ntrk1 cDNA in the Nontumorgenic Breast Epithelial Cell Line MCF-10A

TITLE Overexpression of ntrk1 cDNA in the non tumorgenic breast epithelial cell line MCF-10AJHU Ref. #C13626ABSTRACTThe overexpression of ntrk1 cDNA in the pIRESneo3 plasmid in human non-cancerous breast epithelial cell line MCF-10A. Ntrk1 is amplified in some breast cancers and MCF-10A is a non-cancerous...

Published: 3/13/2025 | Inventor(s): Ben Ho Park, Kelly Kyker-Snowman

Keywords(s): Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Autoantibodies as Anti-cancer Therapeutic Agents

TITLE: Autoantibodies as Anti-cancer Therapeutic AgentsCASE NUMBER: C13604UNMET NEED It has been speculated that autoimmunity and cancer were linked but the missing step was how to turn that concept into a robust method for identifying which specific auto antibodies would be generally effective. This problem was especially acute due...

Published: 3/13/2025 | Inventor(s): Andrew Ewald, Veena Padmanaban, Antony Rosen, Livia Casciola-Rosen

Keywords(s): Antibodies, Biologics, Breast Cancer, Cancers, Disease Indication, Immunotherapy, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Clinical and Disease Specializations > Oncology

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