Search Results - bradley+downs

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Microfluidic Flow Cells to Optimize the Capture of ctDNA in Unaltered Plasma using dCas9

Microfluidic Devices for Liquid Cancer BiopsiesJHU Ref #: [C17525]Value Proposition· Optimized dispersion of ctDNA throughout microfluidic device · Increased rate of capture of ctDNA in dCas9 system· Microfluidics can be combined with apheresis for screening of large volumes of blood plasma· Unaltered plasma can be used for...

Published: 9/27/2024 | Inventor(s): Bradley Downs

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Identification and testing of novel methylated markers that distinguish between primary diffuse large B-cell lymphoma of the central nervous system (DBCL-CNS) and other tumors of the CNS

C16190: Identification and testing of novel methylated markers that distinguish between primary diffuse large B-cell lymphoma of the central nervous system (DBCL-CNS) and other tumors of the CNS Inventors: Saraswati Sukumar, Bradley Downs, Wanjun Ding Unmet NeedGlobally, approximately 300,000 brain cancers are diagnosed each year, which results in about...

Published: 9/27/2024 | Inventor(s): Bradley Downs, Saraswati Sukumar, Wanjun Ding, WeiPing Tao

Keywords(s):

Category(s): Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers

Novel biomarker discovery program to identify methylation markers in cancer

Unmet Need / Invention Novelty: Methylation arrays can be used to identify methylation biomarkers in cancer for development as methylation-specific PCR diagnostic assays. However, existing array data analysis is manually intensive. There is an unmet need to develop a new data analysis tools to identify methylation biomarkers in cancer. Technical Details:...

Published: 9/27/2024 | Inventor(s): Saraswati Sukumar, Bradley Downs

Keywords(s):

Category(s): Copyright, Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations, Technology Classifications, Technology Classifications > Diagnostics

Methylation Markers that Provide Molecular Diagnosis by Distinguishing Between Benign from Malignant Breast Cancer and Predict Risk

Unmet NeedBreast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in low and middle income countries (LMICs), and is expected to increase in incidence due to longer life expectancies, decreased burden of infectious diseases, and changes in reproductive risk factors. In LMICs, breast cancer mortality rates are as high...

Published: 9/26/2024 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Bradley Downs

Keywords(s): Assay, Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Therapeutic Matter, Therapeutics

Capture of ctDNA directly from Flowing Plasma using a dCas9 Capture System

Unmet NeedIt is estimated that, in 2020, 1,806,590 people were diagnosed with cancer and 606,520 people will die from the disease (see NCI). Nevertheless, there are a limited number of molecular diagnostic methods that are routinely deployed in clinical practice. Although the amount of ctDNA is dependent on tumor stage, size, tumor type, among other...

Published: 9/27/2024 | Inventor(s): Bradley Downs

Keywords(s):

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers