Search Results - mary+jo+fackler

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Detection of circulating methylated DNA for high-sensitivity cancer diagnostic and treatment planning

Unmet Need / Invention Novelty: Circulating tumor-associated methylated DNA is an important biomarker for early detection of cancer, risk assessment, predicting and monitoring response to therapy and early detection of relapse. Current tests designed to detect methylated tumor DNA in patient fluids such as the serum and plasma are challenged by low...

Published: 10/3/2024 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Antonio Wolff, Zoila Lopez Bujanda, Wei Wen Teo

Keywords(s): Assay, Clinical Diagnostics, In Vitro Diagnostics

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Technology Classifications > Research Tools

Methylation Markers that Provide Molecular Diagnosis by Distinguishing Between Benign from Malignant Breast Cancer and Predict Risk

Unmet NeedBreast cancer is the most frequently diagnosed cancer and the leading cause of cancer death in low and middle income countries (LMICs), and is expected to increase in incidence due to longer life expectancies, decreased burden of infectious diseases, and changes in reproductive risk factors. In LMICs, breast cancer mortality rates are as high...

Published: 10/4/2024 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Bradley Downs

Keywords(s): Assay, Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Therapeutic Matter, Therapeutics

Methylation markers for stratifying breast cancer, for prognosis, for predicting disease recurrence and response to treatment

C11625: Markers to Differentiate between ER Subtypes, Predict Treatment Outcome and Risk of Reoccurrence in Breast Cancer Value Proposition: - 40 loci have been validated in an independent dataset. - This technology may reveal important biological differences in the epigenome between breast cancer subtypes. - These markers may provide ancillary clinical...

Published: 10/3/2024 | Inventor(s): Mary jo Fackler, Leslie Cope, Antonio Wolff, Peng Huang, Zhe Zhang, Christopher Umbricht, Kala Visvanathan, Saraswati Sukumar

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Pharmakodynamic Biomarker, Prognostic Biomarker, Risk Stratification

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology

J HIN, J RASSF1A, J TWIST, J HIC Plasmids

C10434: Reagents for gene methylation assays. Technical Details: Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfate treatment. The plasmids contain sequences hybridizing to external QM-MSP regions within gene promoters of RASSF1A, TWIST1, NIN1, and HIC1. These areas bracket cloned DNA from non-human sources...

Published: 10/3/2024 | Inventor(s): Mary jo Fackler, Saraswati Sukumar

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

ER alpha M4, ER alpha U4, p16 M4, p16 U5, Hin1 M1, Hin1 U2, RASSF1a M1, RASSF1a U1, RAR beta M1, RAR beta U1, Twist BM2, Twist BU5, APC M3, APC U3, Cylin D2 M1, Cyclin D2 U4, 14-3-3 M2, 14-3-3 U3, HIC1 M1, and HIC1 U3 plasmids

C10165: Reagents, standards, or controls for assays of gene methylation. Technical Details: Plasmid DNAs incorporating human gene-specific promoter sequences altered by sodium bisulfite treatment.Looking for Partners: Their use includes serving as reagents, standards, or controls for assays of gene methylation (e.g. for determining Methylated or unmethylated...

Published: 10/3/2024 | Inventor(s): Mary jo Fackler, Saraswati Sukumar

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

A Novel Method for Quantitatively Analyzing Multiple Genes for the Presence of Methylation in Biological Samples

C04348: Detection of Aberrantly Methylated Genes in Human Samples as Markers of Malignancy Technical Details: Inventors have identified novel genes that may be aberrantly methylated in cancer cells. A method for quantification and diagnosing such methylation has also been developed called quantitative multiplex-methylation specific PCR (QM-MSP). Looking...

Published: 10/3/2024 | Inventor(s): Saraswati Sukumar, Mary jo Fackler, Theresa Swift-Scanlan

Keywords(s): Assay, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics

Aberrantly Methylated Genes as Markers of Breast Malignancy in Ductal Fluids

C03729: Detection of Aberrantly Methylated Genes in Human Samples as Markers of MalignancyTechnical Details: Inventors have identified novel genes that may be aberrantly methylated in cancer cells. A method for quantification and diagnosing such methylation has also been developed called quantitative multiplex-methylation specific PCR (QM-MSP).Advantages:...

Published: 10/3/2024 | Inventor(s): Nicoletta Sacchi, Ella Evron, Mary jo Fackler, Nancy Davidson, William Dooley, Saraswati Sukumar

Keywords(s): Biomarker, Breast Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Breast Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology