Search Results - plasmid

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Induced Pluripotent Stem Cell Lines (BC1 and C7) and Plasmids (pEB-C5, pEB-Tg)

The Material consists of two induced pluripotent stem (iPS) cell lines derived from human bone marrow and cord blood.and plasmids used to create these virus-free and integration-free human iPS cell lines.

Published: 9/26/2024 | Inventor(s): Linzhao Cheng

Keywords(s): Basic Research Biomarker, Cell Model, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Plasmid, Research Reagent, Stem Cells

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

Single Vector Genome Editing with CRISPR/Cas and BacMam

Unmet NeedTargeted, site-specific genome editing is an important scientific tool with broad applications in basic science, the pharmaceutical industry, and translational medicine. It enables the addition of florescent or other types of gene tags for purification, visualization, or tracking. Genome editing can also introduce novel functions for endogenous...

Published: 9/27/2024 | Inventor(s): Chulan Kwon, Renjun Zhu, Amir Saberi

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Other Virus, Plasmid, Research Reagent, Translational Research Biomarker, Viruses

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Viruses

Plasmid Expressing P. Falciparum Aldolase Isolate 3D7

Unmet NeedApproximately 214 million malaria cases were recorded in 2015 with 438,000 people dying from this disease. The majority of these deaths result from a failure to diagnose and treat malaria before the onset of severe disease, at which point, even with proper treatment a 20% mortality rate may be expected. Microscopy is the current gold standard...

Published: 9/26/2024 | Inventor(s): David Sullivan

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

pAR-IRES-EGFP Plasmid

UNMET NEEDThe androgen receptor (AR) is a widely expressed ligand-activated transcription factor which mediates androgen signaling by binding to androgen response elements (AREs) in normal tissue and prostate cancer (PCa). Within tumors, the amount of AR plays a crucial role in determining cell growth, resistance to therapy and progression to fatal...

Published: 9/26/2024 | Inventor(s): John Isaacs

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

Phosphatidylinositol 3-kinase (alpha) Expression Vectors

ABSTRACTResearchers at Johns Hopkins University have developed a set of plasmids that express recombinant P110a/niP85a heterodimer providing the means to purify large quantities of a fusion protein containing the full length phosphatidylinositol 3 kinase alpha (P110α) in complex with residues 322-600 of the regulatory subunit p85. The fusion protein...

Published: 9/26/2024 | Inventor(s): Bert Vogelstein, Sandra Gabelli

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

shRNA knockdown vectors to inhibit expression of specific nuclear Lamin proteins and variants

Invention novelty:JHU researchers have designed and tested several several shRNA knockdown vectors that can inhibit specific isotypes of lamin proteins as well as variants that cause disease.Value Proposition:Many disease arise form aberration in proteins of the nuclear lamina. The researchers have designed and are testing several shRNA knockdown vectors...

Published: 9/26/2024 | Inventor(s): Xianrong Wong, Karen Reddy

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

DNA Constructs to Make Papillomavirus Pseudovirions for HPV Types

These are codon-optimized DNA constructs for the expression of different HPV types major capsid protein, L1 and minor capsid protein, L2, in the vector pVITRO.This Material is also available at Addgene: https://www.addgene.org/Richard_Roden/Related Publication:■ Vaccine. 2010 Jun 17; 28(28): 4478–4486. ■

Published: 9/26/2024 | Inventor(s): Richard Roden

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Disease Indication, Human Papillomavirus, Human Papillomavirus (HPV), Infectious Diseases, Plasmid, Research Reagent, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Vectors & Plasmids, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Polycistronic Plasmids for Mutating Genes

TITLE: Polycistronic plasmids for mutating genesCASE NUMBER: C13607ABSTRACTThe invention is a series of plasmids. Each plasmid drives the expression of (a) two (2) PolIII transcripts encoding CRISPR-based guide RNAs (gRNAs) that target a specific gene and (b) one (1) PolI transcript that expresses a polycistronic ORF encoding (i) Sp Cas9 protein fused...

Published: 9/26/2024 | Inventor(s): Stephen Gould

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools

MH-Gag plasmid (Chimeric MLV/HIV-Gag) aka pSR389

TITLE: MH-Gag plasmid (Chimeric MLV/HIV-Gag) aka pSR389CASE NUMBER: C13554ABSTRACTJHU researchers made use of a chimeric Moloney murine leukemia virus (MMLV)-HIV-1 Gag in which the p17 matrix domain of HIV-1 was replaced with the p15 matrix and p12 domains from MMLV. Murine cells expressing this construct released significant amounts of VLPs. The construct...

Published: 9/26/2024 | Inventor(s): Robert Siliciano, Soon Boon Wong

Keywords(s): Cloning Reagents, Discovery/Research Tools, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Peptides, Plasmid, Recombinant Proteins, Research Reagent, Viral Infections

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

CF8Flp: A Cystic Fibrosis Bronchial Epithelial Cell Line with a Single Integration Site for the Stable Expression of any Gene of Interest

A Cystic Fibrosis Bronchial Epithelial Cell Line (CF8Flp)JHU REF: C12966Invention Novelty: The invention is in the form of a Cystic Fibrosis Bronchial Epithelial Cell Line with an integration site that allows for stable expression of the target protein.Value Proposition:Bronchial epithelial cells have been particularly instrumental in providing a means...

Published: 9/26/2024 | Inventor(s): Garry Cutting

Keywords(s): Basic Research Biomarker, Cell Model, Cloning Reagents, Cystic Fibrosis (CF), Discovery/Research Tools, Disease Indication, Epithelial Cells, Genetic Disorders, In Vitro Research Tool, Plasmid, Research Reagent

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools, Clinical and Disease Specializations > Genetic Diseases > Cystic Fibrosis

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