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Single Vector Genome Editing with CRISPR/Cas and BacMam

Unmet NeedTargeted, site-specific genome editing is an important scientific tool with broad applications in basic science, the pharmaceutical industry, and translational medicine. It enables the addition of florescent or other types of gene tags for purification, visualization, or tracking. Genome editing can also introduce novel functions for endogenous...

Published: 6/20/2024 | Inventor(s): Chulan Kwon, Renjun Zhu, Amir Saberi

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Other Virus, Plasmid, Research Reagent, Translational Research Biomarker, Viruses

Category(s): Technology Classifications > Research Tools > Vectors & Plasmids, Technology Classifications > Research Tools > Viruses

An Efficient Phage Display Based Protease Activity Profiling Platform

Unmet NeedProtein cleavage is a fundamental molecular process, essential to cellular viability and tissue physiology across all kingdoms of life. Human proteases comprise a diverse set of enzymes with at least 569 members, making up five distinct catalytic classes. Cancer associated protease activities are often dysregulated and usually contribute to...

Published: 6/20/2024 | Inventor(s): Harry Larman, Gabriel Roman-Melendez, Thiagarajan Venkataraman

Keywords(s): Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool, Research Reagent, Viruses

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Immuno-Oncology, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Viruses, Technology Classifications > Diagnostics > In Vitro Diagnostics

A Membrane-targeting Construct of NF1 GAP-related Domain (GRD) that Suppresses RAS Activity in NF1-related MPNST, NF1 and other Rasopathies

Unmet NeedNeurofibromatosis type 1 (NF1) is a common genetic disorder that affects approximately 1 in 3,000 individuals worldwide. Patients with NF1 have DNA alterations to the neurofibromin 1 gene which cause RASopathies, a family of diseases caused by altered Ras signaling. RASopathies can include both benign and malignant tumors, including malignant...

Published: 6/20/2024 | Inventor(s): Verena Staedtke, Renyuan Bai

Keywords(s): Adeno-Associated Virus, Biologics, Cancers, Discovery/Research Tools, Disease Indication, Nucleic Acid, Research Reagent, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Viruses

Category(s): Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Gene Therapies, Technology Classifications > Research Tools > Vectors & Plasmids

Scalable Method for Multiplexed Genome Editing

Unmet NeedTargeted genome editing has become a very important genetic tool with broad applications across various areas of science including but not limited to basic science, the pharmaceutical industry, and translational medicine. Presently, one of the most commonly used site-specific, genome editing systems is CRISPR/Cas9, as it enables insertion...

Published: 6/20/2024 | Inventor(s): Chulan Kwon, Renjun Zhu, Amir Saberi

Keywords(s): Adeno-Associated Virus, Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Research Reagent, Viruses

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Vectors & Plasmids

TC-1 (Po)

C03436: TC-1 (Po) Technical Details:This cell line "was developed to circumvent the confounding issue of negatively selecting nonessential tumor markers in cancer vaccine experiments. Primary lung epithelial cells from C57BL/6 mice were immortalized with HPV-16 E6 and E7 and then transformed with the activated ras oncogene. This transformation...

Published: 6/20/2024 | Inventor(s): T.c. Wu

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Mouse Cell Lines, Other Virus, Research Reagent, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Viruses

DPL: Packaging Cell Line For Diphtheria Toxin Expressing Non-replicating Adenovirus

The invention provides a packaging cell line for production of diphtheria toxin (DT) expressing, non-replicating adenovirus for use in suicide gene therapy of cancer cells, as well as production of immunotoxins. Also provided are methods for producing diphtheria toxin (DT) expressing, non-replicating adenovirus, methods for producing immunotoxins, and...

Published: 6/20/2024 | Inventor(s): Wasim Chowdhury, Ronald Rodriguez

Keywords(s): Adeno Virus, Biologics, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Infectious Diseases, Polypeptide, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Viruses, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Peptides

Human Papillomavirus Virus-like-participle Protein

TITLEHuman Papillomavirus Virus-like-participle ProteinCASE NUMBERC04137ABSTRACTVirus-like particles (VLPs) are extraordinary molecules that resemble and mimic the structure of authentic viruses without being infectious. Since they do not contain any viral genetic material, they are able to elicit a strong immune response, without doing any actual...

Published: 6/20/2024 | Inventor(s): Raphael Viscidi

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Human Papillomavirus, Human Papillomavirus (HPV), Infectious Diseases, Other Virus, Research Reagent, Viral Infections, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Viruses, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Polyomavirus Like-particles for Diagnostics and Antibody Development

Novelty: This tangible material is polyomavirus virus like-particles that can be used to measure human antibodies to polyomaviruses in diagnostic assays and to introduce polyomavirus capsid specific antibodies by immunization.Value Proposition: Merkel cell polyomavirus (MCPyV) is a recently discovered polyomavirus in Merkel Cell Carcinoma, a rare and...

Published: 6/20/2024 | Inventor(s): Raphael Viscidi

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, Infectious Diseases, Other Virus, Research Reagent, Viral Infections, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Research Tools > Viruses, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools

Luciferase-tagged Cytomegalovirus (CMV) for High-throughput Drug Screening

Novelty: Luciferase-tagged CMV strains for rapid sensitive anti-CMV drug screening.Value Proposition: To date, the identification of anti-viral agents for cytomegalovirus (CMV), a major threat in immunocompromised people and congenitally-infected children, relies on evaluation of viral replication via plaque assays and real-time PCR. However, these...

Published: 6/20/2024 | Inventor(s): Ravit Boger, Gordon Sandford, Gary Hayward, William Burns

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Labels/Markers, Other Virus, Research Reagent, Target-based Screening Tool, Viruses

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Viruses, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Assays

Cell Line 2V6.11

C10340: Cell Line 2V6.11 Technical Details: The human adenovirus E4 ORF 6 34 kDa oncoprotein (E4 34k), in concert with the 55 kDa product of E1b, prevents concatenation of viral genomes in infected cells, inhibits the repair of double strand breaks (DSBs) in the viral genome, and inhibits V(D)J recombination in a plasmid transfection assay. These...

Published: 6/20/2024 | Inventor(s): Elizabeth Ketner, Gary Ketner

Keywords(s): Adeno Virus, Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Research Reagent, Viruses

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Viruses, Technology Classifications > Research Tools

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