Search Results - infectious+diseases

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Innovative Suit Designs and Doffing Methodologies for Personal Protective Equipment to prevent the spread of Ebola to Health Care Workers

Value Proposition· Increased safety: features back seam entry and exit with integrated doffing and disposal methods to reduce risk of contamination.· Easy to use: Simplified doffing decreases the complexity and time required to doff PPE.· Customizable and comfortable: Design includes sizing adjustments, sweat-wicking features, and...

Published: 3/13/2025 | Inventor(s): Youseph Yazdi, Melody Tan, Matthew Petney, William Patterson, Siavash Parkhideh, Jill Andrews, Patience Osei, Chandrakant Ruparelia, Harshadkumar Sanghvi, Timothy Harrigan, Nahyun Cho, Qian Liu, Sami Messai, Brian Ma, Meagan Hawes, Reeve Heinis, Jason Johnson, Erin Reisfeld, Arjun Vachhani, Timothy Campbell, Neil Rens, Madeleine Clegg, Elizabeth Stokley, Jessica Jeang, Christopher Chiang, Willibrord Shasha, Bailey Topper, Kimberly Ashman, Michael Parlato, Brandon Craft, Paul Fearis, Soumyadipta Acharya

Keywords(s): Disease Indication, Ebola, Industrial Manufacturing, Infectious Diseases, Manufactured Devices, Personal Protective Equipment (PPE), Safety Suits, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Industrial Tech, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Ebola, Clinical and Disease Specializations > Infectious Diseases > Viral Infections, Technology Classifications > Engineering Tech > Industrial Manufacturing

Novel Oxazolidinones for Treatment of Bacterial Infections

Marketing Summary DraftNovel Oxazolidinones for Treatment of Bacterial InfectionsJHU Ref #: C14633Value Proposition· Belong to the same chemical family as Zyvox, marketed by Pfizer, but shows better efficacy· Positive activity demonstrated against M. tuberculosis· MIC values the same or better than the current antibiotics in the...

Published: 3/13/2025 | Inventor(s): Gyanu Lamichhane, J. Ippoliti

Keywords(s): Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Inhibition of nSMase for the Treatment of Human Immunodeficiency Virus Infection

Unmet NeedHuman immunodeficiency virus (HIV) is a retrovirus that negatively impacts the immune system, leading to immunosuppression and increased susceptibility to secondary, opportunistic infections and some cancers. It is estimated that 36.7 million people worldwide are currently living with HIV. Presently, HIV has no cure and requires life-long...

Published: 3/13/2025 | Inventor(s): Norman Haughey, Barbara Slusher, Camilo Rojas

Keywords(s): Antagonists/Inhibitors, Disease Indication, HIV, Infectious Diseases, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases > HIV

Transgenic Fungi that Kill Malaria Parasites in Mosquitoes

Invention novelty: This material is a transgenic fungus which targets the sporozoites that cause malaria in the salivary glands of mosquitoes. The fungus is taken up by direct contact with the mosquito and inhibits Plasmodium development. Value Proposition: Unmodified, Metarhizium anisopliae kills mosquitoes slowly. If mosquitoes are infected by the...

Published: 3/13/2025 | Inventor(s): Raymond St. Leger, Angray Kang, Weiguo Fang, Marcelo Jacobs-Lorena

Keywords(s): Biologics, Disease Indication, Disease Management System, Healthcare Management, Infectious Diseases, Malaria, Operations Management, Parasitic Infections, Protein, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Proteins, Technology Classifications > Computers, Electronics & Software, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Infectious Diseases > Parasitic Infections

Antiviral Azide Containing Compounds

Unmet Need: Viral infections in humans, animals, plants and insects lead to many societal burdens including disease and agricultural loss. Most anti-viral treatment strategies to date are limited in scope to the virus of interest and often result in drug resistance, incomplete efficacy, and/or toxicity. Costs for viral specific targets can be massive...

Published: 3/13/2025 | Inventor(s): Upinder Singh, Scott Grecian, Brian Agnew, David Graham

Keywords(s): Antagonists/Inhibitors, Disease Indication, Drug Delivery Mechanism, Infectious Diseases, Oral Administration, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities

Improved Production of Clavulanic Acid by Genetic Engineering of Streptomyces Clavuligerus

Clavulanic acid is a potent b-lactamase inhibitor used to combat resistance to penicillin and cephalosporin antibiotics. There is a demand for high-yielding fermentation strains for industrial production of this valuable product. Clavulanic acid biosynthesis is initiated by the condensation of L-arginine and D-glyceraldehyde-3-phosphate (G3P). To overcome...

Published: 3/13/2025 | Inventor(s): Rong-feng Li, Craig Townsend

Keywords(s): Bacterial Infections, Basic Research Biomarker, Cell Signaling, Discovery/Research Tools, Disease Indication, Infectious Diseases, Inhibitors, Research Reagent, Therapeutic Method, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Novel HIV Antiviral Proteins and Their Uses in Therapeutic Methods

Unmet Need: HIV infection remains a significant global health burden despite availability of current antiviral treatments. With increasing drug resistance against available therapeutics, there is an urgent need for additional strategies to treat HIV. Technical Details: Researchers at Johns Hopkins University have identified novel candidates for HIV...

Published: 3/13/2025 | Inventor(s): David Thomas, Ashwin Balagopal, Ramy El-Diwany, Robert Siliciano, Joel Blankson, Stuart Ray, Michael Chattergoon, Justin Bailey

Keywords(s): Biomarker, Disease Indication, HIV, HIV/AIDS, Infectious Diseases, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > HIV/AIDS, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Antigens Derived from Biofilm-like Microcolony Persister Form of Borrelia burgdorferi Improve Serodiagnosis of Lyme Disease

Unmet NeedLyme disease is one of many tick-transmitted diseases. Further investigation has revealed that Lyme disease is caused by the bacterium Borrelia burgdoferi. These bacteria transmit to humans via an infected deer tick and has affected over 25,000 Americans in the United States in 2002. Currently there are estimated to be 300,000 cases a year...

Published: 3/14/2025 | Inventor(s): Ying Zhang

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics (Old), Infectious Diseases, Lyme Disease

Category(s): Clinical and Disease Specializations > Infectious Diseases > Lyme Disease, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Method to Use Viral and Host Methylation Markers for Cervical Cancer Screening and Triage in Liquid Prep, Serum/plasma, and Urine: PCR and Sequencing Based Process Methods

Novel Method for Cervical Cancer ScreeningJHU REF: C13649Invention novelty: This invention is a diagnostic method for diagnosis and progression monitoring of premalignant lesions in cervical cancer via DNA methylation and quantitative Methylation Specific PCR (qMSP).Value Proposition:Currently, the primary diagnostic for cervical cancer is a Papanicolaou...

Published: 3/13/2025 | Inventor(s): Rafael Guerrero-Preston, David Sidransky

Keywords(s): Biomarker, Clinical Diagnostics, Diagnostic Tool, Disease Indication, Epigenetic, Human Papillomavirus, Human Papillomavirus (HPV), In Vitro Diagnostics (Old), Infectious Diseases, Measurement Tool, Methylation, Viral Infections

Category(s): Clinical and Disease Specializations, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Human Papillomavirus, Clinical and Disease Specializations > Infectious Diseases > Viral Infections

Method to Enhance Pulmonary Dendritic Cell-mediated DNA Vaccination

Unmet NeedWith lung diseases, namely influenza and lung cancer, on the rise, pulmonary vaccination is a promising approach to elicit strong immunity to inhaled pathogens and lung cancer compared to systemic immunization strategies. In particular, inhaled DNA vaccination, a rapidly developing field, can potentially promote humoral and cellular immunity...

Published: 3/14/2025 | Inventor(s): Jung Soo Suk, Yoo Chun Kim, Justin Hanes

Keywords(s): Biologics, Cancers, Disease Indication, Drug Delivery Vehicle, Immunotherapy, Infectious Diseases, Influenza, Lung Cancer, Nanoparticles, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Tuberculosis (TB), Vaccine

Category(s): Clinical and Disease Specializations > Infectious Diseases > Tuberculosis (TB), Clinical and Disease Specializations > Infectious Diseases > Influenza, Clinical and Disease Specializations > Immunology, Clinical and Disease Specializations > Immuno-Oncology, Clinical and Disease Specializations > Oncology > Lung Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Therapeutic Modalities > Vaccines

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