Search Results - gyanu+lamichhane

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Novel Oxazolidinone Antibacterials and the Synthetic Routes to Them

Marketing Summary Draft Novel Oxazolidinone Antibacterials and the Synthetic Routes to ThemJHU Ref #: C18144Value Proposition· Higher efficacy and lower toxicity oxazolidinone compounds· Positive activity demonstrated against M. abscessus· MIC values are the same or better than the current antibiotics in the market Unmet Need The...

Published: 6/28/2024 | Inventor(s): Gyanu Lamichhane, J. Ippoliti, Cole Friederichs, Connor Winkelhake, Ben Thompson, Kelsey Latterell

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Novel Oxazolidinones for Treatment of Bacterial Infections

Marketing Summary DraftNovel Oxazolidinones for Treatment of Bacterial InfectionsJHU Ref #: C14633Value Proposition· Belong to the same chemical family as Zyvox, marketed by Pfizer, but shows better efficacy· Positive activity demonstrated against M. tuberculosis· MIC values the same or better than the current antibiotics in the...

Published: 6/27/2024 | Inventor(s): Gyanu Lamichhane, J. Ippoliti

Keywords(s): Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Novel Molecular Method for the Detection of Mycobacterium Tuberculosis

Unmet NeedTuberculosis (TB) is a potentially serious infectious respiratory disease that is spread via coughs and sneezes. TB is one of the world’s deadliest diseases; one-fourth of the global population is currently infected with TB. In 2016 alone, 10.4 million people contracted TB with 1.7 million TB-related deaths. Lack of resources in developing...

Published: 6/27/2024 | Inventor(s): Pankaj Kumar, Gyanu Lamichhane

Keywords(s): Assay, Biomarker, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Infectious Diseases, Tuberculosis

Category(s): Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Assays

A Combination of Carbapenem and Avibactam for Treatment of Bacterial Infections

UNMET NEEDMultidrug-resistant (MDR) pathogens, e.g. Mycobacterium tuberculosis (TB) are a growing threat with significant economic ramifications. In particular, TB is one of the top 10 causes of death worldwide, with an estimated 10.4 million people infected, globally. An estimated 1.8 million deaths are attributable to TB. MDR-TB is TB that does not...

Published: 6/27/2024 | Inventor(s): Gyanu Lamichhane

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Combination, Disease Indication, Infectious Diseases, Non-novel, Predicted Novelty, Repurposed, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

An Oxazolidinone for Treatment of Infections with Mycobacterium Tuberculosis and Gram Positive Bacteria

TITLE: An Oxazolidinone for Treatment of Infections with Mycobacterium Tuberculosis and Gram Positive BacteriaCASE NUMBER: C13966UNMET NEEDTuberculosis (TB) is still one of the most difficult infectious diseases to treat, and the second most frequent cause of death due to infectious disease throughout the world. The number of cases of multidrug-resistant...

Published: 6/27/2024 | Inventor(s): Gyanu Lamichhane, J. Ippoliti

Keywords(s): Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Tuberculosis, Tuberculosis (TB)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Novel Inhibitors of Bacterial Growth

Novel Inhibitors of Bacterial GrowthJHU REF: C13624Invention novelty: Novel antibacterials that inhibit non-classical transpeptidases.Value Proposition: Resistance to existing antibacterials is being reported at an alarming rate. Therefore, new antibacterials that work by inhibiting novel enzymes would be of high utility in treating bacterial infections....

Published: 6/27/2024 | Inventor(s): Gyanu Lamichhane, Joel Freundlich, Shaogang Li, Sean Ekins, Craig Townsend, Evan Lloyd, Nicole Parrish, Amit Kaushik, Pankaj Kumar

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

Molecular Target of Mycobacterium Tuberculosis for Development of Drug and Vaccine

Susceptibility Target for TB TherapyJHU REF: C10895Invention novelty: This invention has identified a new target and a new way to kill the Mycobacterium tuberculosis pathogen.Value Proposition: Currently the mechanism by which M. tuberculosis maintains 3-3 cross-linkages in the peptidoglycan layer is not fully understood. Inventors at JHU and Universite...

Published: 6/27/2024 | Inventor(s): Jean-Luc Mainardi, Marie Lavollay, Michel Arthur, Radhika Gupta, Gyanu Lamichhane, William Bishai

Keywords(s): Bacterial Infections, Biomarker, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Infectious Diseases, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics, Tuberculosis, Tuberculosis (TB)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Clinical and Disease Specializations > Infectious Diseases > Tuberculosis, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities

A Library of a Large Collection of Genotypically Defined Mutants

C04275: A Library of a Large Collection of Genotypically Defined Mutants Value Proposition: Tuberculosis is a serious and lethal infectious disease that exists worldwide. There is a recognized need to understand the infectivity mechanisms used by mycobacterium to identify useful therapeutic and prophylactic targets. JHU researchers have generated...

Published: 6/27/2024 | Inventor(s): Deborah Geiman, Gyanu Lamichhane, Matteo Zignol, William Bishai

Keywords(s): Biomarker, Clinical Diagnostics, Computer and Network Systems, Computer Software, Computing; Calculating; Counting, Data Processing Systems or Methods, Specifically Adapted fo~, Data Processing Systems or Methods, Specifically Adapted for, Database Management Software, In Vitro Diagnostics, Physics

Category(s): Technology Classifications > Computers, Electronics & Software > Financial Tech, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Databases, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Diagnostics > Diagnostic Biomarkers