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New Antibacterials Against D,D- and L,D-Transpeptidases

Unmet needb-lactam antibacterial agents target peptidoglycan biosynthesis and are used for treatment of infection, but have been ineffective in treatment of Tuberculosis (TB). This lack of activity has been attributed to the presence of b-lactamase and limited penetration of the thick mycolate coat. Thus, new generation of antibacterial agents to treat...

Published: 7/4/2024 | Inventor(s): Craig Townsend, Evan Lloyd

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections

Novel Inhibitors of Bacterial Growth

Novel Inhibitors of Bacterial GrowthJHU REF: C13624Invention novelty: Novel antibacterials that inhibit non-classical transpeptidases.Value Proposition: Resistance to existing antibacterials is being reported at an alarming rate. Therefore, new antibacterials that work by inhibiting novel enzymes would be of high utility in treating bacterial infections....

Published: 7/4/2024 | Inventor(s): Gyanu Lamichhane, Joel Freundlich, Shaogang Li, Sean Ekins, Craig Townsend, Evan Lloyd, Nicole Parrish, Amit Kaushik, Pankaj Kumar

Keywords(s): Antagonists/Inhibitors, Bacterial Infections, Disease Indication, Infectious Diseases, Novel, Predicted Novelty, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases > Bacterial Infections, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Therapeutic Modalities