Search Results - in+vitro+research+tool

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Efficient, Expansive, User-defined DNA Mutagenesis

C12015: Efficient, Expansive, User-defined DNA MutagenesisNovelty: This invention provides a leap forward in saturation mutagenesis called PFunkel. PFunkel is a next-generation Kunkel mutagenesis strategy that can, for the first time, efficiently and cheaply produce libraries containing user-defined mutations, including sequentially permuted genes....

Published: 3/13/2025 | Inventor(s): Elad Firnberg, Marc Ostermeier

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Know-how

Category(s): Technology Classifications > Research Tools

K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells

C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...

Published: 3/13/2025 | Inventor(s): Ben Ho Park

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, Discovery/Research Tools, Epithelial Cells, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Isolation of Fungal Melanin Granules from Culture Supernatants

Unmet NeedMelanins are multifunctional pigments that have applications in numerous fields, including drug development, radioprotection, bioremediation, solar power, and cosmetics. Melanin pigments have broad optical absorption and are capable of absorbing ionizing radiation. Melanin pigments also have powerful antioxidant activity and are capable of...

Published: 3/14/2025 | Inventor(s): Radames Cordero, Arturo Casadevall, Raghav Vij

Keywords(s): Bioreactor-based Manufacturing, Discovery/Research Tools, In Vitro Research Tool, Industrial Manufacturing, Yeast Model

Category(s): Technology Classifications > Industrial Tech > Bioreactors, Technology Classifications > Engineering Tech > Bioreactors

Hybridoma expressing anti-RG-1 mAb for the study of human papillomavirus L2

Technology DescriptionJHU scientists generated a hybridoma expressing a monoclonal antibody, RG-1, that binds to highly conserved L2 residues and neutralizes human papillomavirus 16 (HPV16) and HPV18. Passive immunotherapy with RG-1 was protective in mice. Antiserum to the HPV16 L2 peptide comprising conserved residues neutralized pseudoviruses HPV5,...

Published: 3/13/2025 | Inventor(s): Ratish Gambhira, Richard Roden

Keywords(s): Antibodies, Basic Research Biomarker, Cell Model, Discovery/Research Tools, Hybridomas, In Vitro Research Tool, Monoclonal Antibodies, Research Reagent

Category(s): Technology Classifications > Research Tools > Antibodies, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Phenotypic Microarray for Diagnosis of Cancer

Invention novelty: High Throughput Screening of pancreatic cancer cells by developing a phenotypic microarray Value Proposition: The market for cancer diagnostics is ever-expanding as the focus of global research on cancer reached its peak in the past five years. The use of microarrays as an ideal diagnostic tool for cancer detection is being realized...

Published: 3/13/2025 | Inventor(s): Denis Wirtz, Pei-Hsun Wu, Shyam Khatau, Wei-Chiang Chen, Zev Binder, Jude Phillip, Yiider Tseng

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vitro Research Tool, Pharmakodynamic Biomarker, Prognostic Biomarker, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Technology Classifications > Research Tools > Assays

Detection of Low Abundant Molecules in Complex Mixture

Invention novelty: a method for quantitative, high-throughput analysis of glycans from tissue sections Value PropositionStudies on protein glycosylation have been complicated by the diverse structure of protein glycans and the lack of effective tools to identify the protein glycosylation site and glycan structure. Currently, mass spectrometry is the...

Published: 3/13/2025 | Inventor(s): Xingde Li, Shadi Eshghi, Hui Zhang

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Research Tools

Albumin-Flt3L Fusion Protein to Enhance Anti-Tumor Immunity and Antigen-specific T-cell Cytotoxicity

Unmet Need: Active immunotherapy, such as anti-PD-1/PD-L1 and anti-CTLA-4 checkpoint blockage, involves the administration of molecules to mobilize host immune cells to recognize and kill tumors. Proper presentation of tumor antigens through antigen presenting cells is a prerequisite to elicit a potent immune response. Current strategies enhance antigen...

Published: 3/13/2025 | Inventor(s): T.c. Wu, Chien-Fu Hung, Brandon Lam

Keywords(s): Biologics, Cancers, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Research Instrument, Target, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Clinical and Disease Specializations > Immunology, Technology Classifications, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Targets

Repetitive Element Aneuploidy Sequencing Systems (REAL-SeqS)

Unmet NeedAneuploidies are chromosomal alterations that are present in the majority of cancers and associated with numerous genetic disorders. Consequently, the detection of aneuploidy in clinical samples has important applications in prenatal testing and cancer diagnostics. The current, noninvasive methods for detecting aneuploidy in clinical samples...

Published: 3/14/2025 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Christopher Douville, Nickolas Papadopoulos, Cristian Tomasetti

Keywords(s): Analytical Method, Discovery/Research Tools, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Nucleic Acids

Alpha 2 Collagen VIII (Col8a2) Q455K Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy

Unmet Need:Fuchs’ endothelial corneal dystrophy (FECD) is a genetic disease affecting the cornea and is estimated to affect 7% of the adult population (see Aiello et al. 2022). The first genetic defect shown to cause FECD was a point mutation in the alpha 2 collagen 8 gene (Col8a2). The disease results in a buildup of fluid in the cornea and causes...

Published: 3/13/2025 | Inventor(s): Albert Jun

Keywords(s): Basic Research Biomarker, Cell Lines, Corneal Dystrophy, Discovery/Research Tools, Disease Indication, Eye Disorders, Fuchs' Endothelial Corneal Dystrophy, Fuchs Endothelial Corneal Dystrophy (FECD), In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy

Isogenic SF3B1 cell lines for drug discovery

SF3B1 mutations are present in a number of cancers. These mutations cause abnormal splicing within human cells and can lead to genomic alterations that confer cancerous phenotypes. Our research has led to the creation of isogenic cell lines that have specific mutations within the SF3B1 gene, thus mimicking human cancer mutations. In addition, we have...

Published: 3/13/2025 | Inventor(s): Ben Ho Park, William Dalton

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines

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