Search Results - in+vitro+research+tool

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hPSC-derived Oligodendrocyte Reporter Cell System for Screening of Myelination Enhancing Drugs

Unmet NeedA study in 2017 funded by the National MS Society shows that nearly one million people are living with Multiple sclerosis (MS) in the United States. MS is a degenerative disease with no cure. In MS the central nervous system is damaged by the degradation of the protective sheath, called myelin, around the neurons. The cause is unclear, but...

Published: 3/13/2026 | Inventor(s): Donald Zack, Xitiz Chamling

Keywords(s): Discovery/Research Tools, In Vitro Research Tool, Target-based Screening Tool

Category(s): Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Technology Classifications > Research Tools > Human Cell Lines

Low Cost Regulated Genetic Switch for Saccharomyces Cerevisiae

Low Cost Regulated Genetic Switch for Saccharomyces CerevisiaeJHU REF: C12857 Invention Novelty: This technology is a method of using a low cost regulated system for controlling gene expression in the yeast Saccharomyces cerevisiae. Value Proposition:Budding yeast Saccharomyces cerevisiae is one of the most important organisms in biotechnology. Currently...

Published: 3/12/2026 | Inventor(s): Jef Boeke, Shigehito Ikushima

Keywords(s): Cell Signaling, Discovery/Research Tools, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent, Yeast Model

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Yeast Model

Biomimetic Platforms to Model Vascular Pathophysiology, Diagnostics, and Therapy

Value Proposition· Biomimetic platform of human pulmonary arterioles that enables researchers and clinicians to better understand pulmonary hypertension.· Precisely engineered, tunable, functional, and anatomically accurate biomimetic human pulmonary microvasculature supports quantitative analysis of endothelial and smooth muscle cell...

Published: 3/12/2026 | Inventor(s): Lewis Romer, David Gracias, Jayson Pagaduan, Anil Bhatta, Xing Chen, Qianru Jin

Keywords(s): Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Lung Disorders, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Respiratory Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Immortalized Human DRG Neuronal Cell Line

Unmet NeedPeripheral neuropathy is estimated to affect 20 million people in the U.S. alone. Patients suffer from a number of symptoms including: numbness, tingling, pricking sensations, muscle weakness, abnormal sensitivity to touch, and feelings of burning pain. Two of the most common causes of peripheral neuropathy are the result of diabetes and toxicity...

Published: 3/13/2026 | Inventor(s): Ahmet Hoke, Weiran Chen, Gabsang Lee

Keywords(s): Basic Research Biomarker, Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Stem Cells

Category(s): Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Stem Cells

A Novel-fate Marking Strategy to Permanently Tag Hypoxic Cancer Cells

Value Proposition· Permanently labels cells that have experienced hypoxia, enabling long-term tracking· Captures tumor evolution by identifying cells with past hypoxia exposure, not just at the time of tissue collection· Enables investigation of metastasis by tracking cells from hypoxic niches that may retain aggressive phenotypes· Supports...

Published: 3/13/2026 | Inventor(s): Daniele Gilkes, Ines Godet

Keywords(s): Breast Cancer, Cancers, Cardiovascular Diseases, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, In Vivo Research Tool, Mouse Model, Translational Research Biomarker

Category(s): Clinical and Disease Specializations > Oncology, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines

Muscular Dystrophy Cell Lines

Unmet NeedFacioscapulohumeral muscular dystrophy (FSHD) is a complex neuromuscular disorder affecting 1 in 20,000 individuals. The disease is characterized by progressive wasting of facial, upper arm and shoulder girdle muscles. FSHD has variable age of onset, ranging from infant to late adult; and approximately one-third of patients lose the ability...

Published: 3/13/2026 | Inventor(s): Kathryn Wagner

Keywords(s): Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Muscular Dystrophy

Category(s): Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Musculoskeletal > Muscle Atrophy

SCA12 Tools – SCA12 Fibroblasts, iPSCs and Polyclonal Antibodies to Investigate SCA12

Value PropositionFirst in class patient-derived biological tools for investigation of SCA12, a rare neurodegenerative disease with no known cure. Unmet NeedSpinocerebellar ataxia type 12 (SCA12) is a rare neurodegenerative disease that affects the cerebellum, commonly resulting in upper limb tremors and muscle spasms, with some patients reporting a...

Published: 3/13/2026 | Inventor(s): Russell Margolis, Pan Li, Christopher Ross

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Neurology > Neurodegeneration

Ligation in situ Hybridization for highly multiplexed RNA analysis of fixed tissue specimens

Unmet Need: Formalin fixed and paraffin embedded (FFPE) tissues are the most common form of patient specimens analyzed by pathologists. This standard practice of preserving clinical samples, however, dramatically damages the RNA content of these valuable specimens. RNA molecules provide important information about which genes are being expressed in...

Published: 3/12/2026 | Inventor(s): Harry Larman, Joel Credle

Keywords(s): Discovery/Research Tools, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools

Tamoxifen-Inducible Mouse Model for Enhanced Labeling of Tyrosine Hydroxylase-Expressing Neurons

Value Proposition· Enhanced labeling efficiency: The TH-2A-CreER mouse line achieves higher labeling efficiency compared to existing mouse lines through the 2A peptide system that ensures elevated CreER expression levels· Multi-population targeting: Enables labeling and functional manipulation of TH-expressing neuronal populations including...

Published: 3/12/2026 | Inventor(s): David Ginty

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Efficient, Expansive, User-defined DNA Mutagenesis

C12015: Efficient, Expansive, User-defined DNA MutagenesisNovelty: This invention provides a leap forward in saturation mutagenesis called PFunkel. PFunkel is a next-generation Kunkel mutagenesis strategy that can, for the first time, efficiently and cheaply produce libraries containing user-defined mutations, including sequentially permuted genes....

Published: 3/12/2026 | Inventor(s): Elad Firnberg, Marc Ostermeier

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Know-how

Category(s): Technology Classifications > Research Tools

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