Search Results - analytical+method

6 Results

Sort By:

Repetitive Element Aneuploidy Sequencing Systems (REAL-SeqS)

Unmet NeedAneuploidies are chromosomal alterations that are present in the majority of cancers and associated with numerous genetic disorders. Consequently, the detection of aneuploidy in clinical samples has important applications in prenatal testing and cancer diagnostics. The current, noninvasive methods for detecting aneuploidy in clinical samples...

Published: 6/20/2024 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Christopher Douville, Nickolas Papadopoulos, Cristian Tomasetti

Keywords(s): Analytical Method, Discovery/Research Tools, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Nucleic Acids

A Novel mAb20-based In-cell ZnT8 Assay

Unmet Need: Prevalence of Type 2 Diabetes (T2D) continues to rapidly increase worldwide, contributing significant economic and global health burdens. There is an urgent need for the development of novel therapeutic strategies to treat T2D.Technical Details: Johns Hopkins researchers have identified a novel target to treat T2D and report here the development...

Published: 6/21/2024 | Inventor(s): Dax Fu, Chengfeng Merriman

Keywords(s): Analytical Method, Diabetes, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Metabolic Disorders, Proteomics/Immunoassays, Research Reagent, Target-based Screening Tool, Type II Diabetes

Category(s): Clinical and Disease Specializations > Diabetes > Type 2 Diabetes, Technology Classifications > Research Tools > Assays, Technology Classifications > Therapeutic Modalities > Targets

EXoO-Tn Tag-n-Pin the Pan-Carcinoma Tn Antigen in Human Proteome

Unmet NeedAberrant glycosylation has been implicated as a mechanism of cancer progression. Accordingly, identifying the differences in glycan structures within clinical specimens, cancer, and normal cells provides a unique opportunity to identify new biomarkers and therapeutic targets. In particular, Tn antigen (Tn) is a simple O-linked glycan structure...

Published: 6/20/2024 | Inventor(s): Hui Zhang, Weiming Yang

Keywords(s): Analytical Method, Assay, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool, Pancreatic Cancer, Pancreatic ductal adenocarcinoma

Category(s): Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers

Use of PCR Fragments with Short Homology Arms for Genome Editing

Unmet NeedThe RNA-guided DNA endonuclease, Cas9, has emerged as a powerful new tool for genome engineering. Cas9 creates targeted ‘double-strand breaks’ (DSBs) in the genome. Knock-in of specific mutations (precision genome editing) requires ‘homology-directed repair’ (HDR) of the DSB by synthetic donor DNAs containing the desired edits, but HDR has...

Published: 6/20/2024 | Inventor(s): Geraldine Seydoux, Alexandre Paix

Keywords(s): Analytical Method, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Nucleotide, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Nucleic Acids

A CRISPR-based yeast two-hybrid system for investigating RNA-protein interaction

Unmet Need: DNA-sequencing technology has led to the development of many powerful techniques, such as RIP-seq and CLIP-seq, which can be used to identify many RNAs bound by a protein of interest, however, few protocols exist for identifying the proteins bound to a particular RNA. Most available techniques involve RNA pull-down followed by protein identification...

Published: 6/20/2024 | Inventor(s): David Zappulla, Evan Hass

Keywords(s): Analytical Method, Assay, Clinical Diagnostics, Discovery/Research Tools, In Vitro Diagnostics, In Vitro Research Tool, Target-based Screening Tool, Yeast Model

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics

C13826: Quantitative Determination of Nucleoside Analogue Drugs in Genomic DNA or RNA

Unmet Need:Hematologic and epithelial malignancies have been shown to progress by epigenetically silencing genes that code for tumor suppressors, cell cycle regulators or proteins involved in cell-cell interaction. Gene suppression occurs through promoter methylation and modification of histones. Drugs which are able to manipulate promoter methylation...

Published: 6/20/2024 | Inventor(s): Michelle Rudek-Renaut, Srinivasan Yegnasubramanian, Nicole Anders

Keywords(s): Analytical Method, Assay, Biomarker, Cancers, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, Epigenetic, In Vitro Diagnostics, In Vitro Research Tool, Methylation

Category(s): Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Assays