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Use of PCR Fragments with Short Homology Arms for Genome Editing

Unmet NeedThe RNA-guided DNA endonuclease, Cas9, has emerged as a powerful new tool for genome engineering. Cas9 creates targeted ‘double-strand breaks’ (DSBs) in the genome. Knock-in of specific mutations (precision genome editing) requires ‘homology-directed repair’ (HDR) of the DSB by synthetic donor DNAs containing the desired edits, but HDR has...

Published: 9/26/2024 | Inventor(s): Geraldine Seydoux, Alexandre Paix

Keywords(s): Analytical Method, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Nucleotide, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Nucleic Acids