Search Results - nucleotide

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Identification of RNF43 Mutations in Pancreatic Cysts

Unmet Need· One third of diagnoses for surgical resection of pancreatic cysts are incorrect, leading to unnecessary surgery, medical risk, and high costs (Hammel, 2002). The current standard of care for determining pancreatic cyst type is based solely on symptom progression and imaging criteria, and histopathological analysis is only available...

Published: 3/13/2025 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Jian Wu, Anirban Maitra, Ralph Hruban, Marco Dal Molin

Keywords(s): Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, Nucleotide, Pancreatic Cancer, Research Reagent, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers

HIF-1(alpha)CA5: A Stable and Constitutively-Active Form of HIF-1(alpha)

Technical Overview: Animals and people are dependent on a continuous supply of O(2) for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. Vascularization and vascular remodeling represent critical adaptive responses to tissue hypoxia...

Published: 3/13/2025 | Inventor(s): Gregg Semenza

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Nucleotide, Research Reagent

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Nucleic Acids

Use of PCR Fragments with Short Homology Arms for Genome Editing

Unmet NeedThe RNA-guided DNA endonuclease, Cas9, has emerged as a powerful new tool for genome engineering. Cas9 creates targeted ‘double-strand breaks’ (DSBs) in the genome. Knock-in of specific mutations (precision genome editing) requires ‘homology-directed repair’ (HDR) of the DSB by synthetic donor DNAs containing the desired edits, but HDR has...

Published: 3/13/2025 | Inventor(s): Geraldine Seydoux, Alexandre Paix

Keywords(s): Analytical Method, Cloning Reagents, Discovery/Research Tools, In Vitro Research Tool, Nucleotide, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Nucleic Acids

Diagnostic Assays For a Polymorphism in the SCARB1 Gene That Affects Expression and Function of the Receptor

Unmet Need:High density lipoproteins (HDL) are considered good or healthy cholesterol that can protect against heart disease. However, there are people who have health problems despite having desirable levels of HDL. There are a number of factors that can contribute to the blood levels of HDL, including genetic problems and lifestyle choices. There...

Published: 3/13/2025 | Inventor(s): Annabelle Rodriguez

Keywords(s): Biomarker, Cardiovascular Diseases, Clinical Diagnostics, Cloning Reagents, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Nucleotide, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Research Tools > Nucleic Acids

Enabling technology for epigenetic drug development

Invention novelty: This invention describes an improved histone reporter system that enables epigenetic therapeutic development in cell-based assays and potential therapeutic monitoring in animal models.Value PropositionIt is now widely appreciated that most human diseases are contributed by interplay of genetic and epigenetic factors. Understanding...

Published: 3/13/2025 | Inventor(s): Harry Dietz, Hans Bjornsson

Keywords(s): Basic Research Biomarker, Biomarker, Clinical Diagnostics, Cloning Reagents, Discovery/Research Tools, Epigenetic, In Vitro Diagnostics, In Vitro Diagnostics (Old), In Vitro Research Tool, Nucleotide, Research Reagent, Target-based Screening Tool

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers

The Antisense Transcriptomes of Human Cells

C10567: The Antisense Transcriptomes of Human Cells - ASSAGE (Asymmetric Strand Specific Analysis of Gene Expression)Value Proposition: • Novel method to determine DNA strand origin • Combination method which includes the quantitation of both sense and antisense transcripts • This method can be utilized from expressed genes...

Published: 3/13/2025 | Inventor(s): Victor Velculescu, Kenneth Kinzler, Nickolas Papadopoulos, Yiping He, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Cloning Reagents, Discovery/Research Tools, Nucleotide, Research Reagent

Category(s): Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools

SIV Clonal Isolates: SIV/17E-Fr, SIV/17E-C1, SIV/3-11RG, and SIV/3-7

C04943: SIV Clonal Isolates: SIV/17E-Fr, SIV/17E-C1, SIV/3-11RG, and SIV/3-7 Technical Details: JHU researchers have constructed infectious simian immunodeficiency virus (SIV) molecular clones that differ in their Env and Nef proteins. These clones display differences in neurovirulence and cellular tropism.Looking for Partners: SIV clones for...

Published: 3/13/2025 | Inventor(s): Janice Clements

Keywords(s): Cloning Reagents, Discovery/Research Tools, Disease Indication, Infectious Diseases, Nucleotide, Other Virus, Plasmid, Research Reagent, Translational Research Biomarker, Viruses

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Infectious Diseases, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Research Tools > Viruses, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Vectors & Plasmids

Nucleotides that Produce DNA Interstrand Cross-links

C04741: Method of clearing a DNA lesion to make DNA-related therapy more effectiveValue Proposition: • This efficient process should provide the great force to design novel DNA cross-linking agents. • From research point of view, this technology will greatly facilitate the study of the biological effects of this important family of DNA...

Published: 3/13/2025 | Inventor(s): Marc Greenberg

Keywords(s): Biomarker, Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, Nucleotide, Pharmakodynamic Biomarker, Research Reagent, Therapeutic Matter, Therapeutics, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

Synphilin-1, a Protein which Associates with Alpha-Synuclein and Promotes the Formation of Cytostolic Inclusions

C03531: Synphilin-1, a Protein which Associates with Alpha-Synuclein and Promotes the Formation of Cytostolic Inclusions Technical Details: Complementary DNA encoding the neural protein ?synphilin-1? was cloned via the protein?s interaction with synuclein, a previously identified product which has been genetically linked to Parkinson?s Disease. Though...

Published: 3/13/2025 | Inventor(s): Christopher Ross, Simone Engelender

Keywords(s): Cloning Reagents, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Nucleotide, Parkinson's Disease, Research Reagent

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Parkinson's Disease, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools