Search Results - christopher+ross

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HDL2 iPSCs

Invention Novelty: Generation of three lines of induced pluripotent stem cells derived from fibroblast cell lines developed from patients with Huntington's disease-like 2.Value Proposition: HDL2, discovered and genetically defined by the Margolis group, is a rare, autosomal dominant neurodegenerative disorder, clinically and neuropathologically...

Published: 3/13/2025 | Inventor(s): Russell Margolis, Christopher Ross, Dobrila Rudnicki, Hongjun Song, Sergey Akimov

Keywords(s): Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Ankyrin-G and Ion Channel Pathway Cell Model for Testing Psychiatric Therapeutics

TITLE Ankyrin-G and Ion Channel Pathway Cell Model for Testing Psychiatric TherapeuticsCASE NUMBERC13171ABSTRACTL-Type calcium channel loci and the Ankyrin-G locus have emerged from Genome-Wide Association Studies as among the major risk factors for human psychiatric disorders, and Johns Hopkins researchers...

Published: 3/13/2025 | Inventor(s): Shanshan Zhu, Christopher Ross

Keywords(s): Cell Signaling, Discovery/Research Tools, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent, Target-based Screening Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays

Multiple Lines of Induced Pluripotent Stem Cells (iPSCs) Derived from Members of an American Family with, and without DISC1 Mutations Associated with Schizophrenia and Depression

Invention Novelty: These tangible materials are induced Pluripotent Stem Cells (iPSCs) derived from members with or without DISC1 (Disrupted in schizophrenia 1) mutations in an American family associated with schizophrenia. Value Proposition:Mutations in DISC1 have been shown to predispose individuals to the development of psychiatric illnesses such...

Published: 3/13/2025 | Inventor(s): Hongjun Song, Christopher Ross, Guo-li Ming, Russell Margolis

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Schizophrenia, Stem Cells, Target-based Screening Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools > Human Cell Lines

Cell lines Derived from Huntington’s Disease Induced Pluripotent Stem Cells, and their Use for Identification of Novel Therapeutics

TITLE Cell lines derived from Huntington’s disease induced Pluripotent Stem CellsJHU REF. #C14273ABSTRACTCell models of Huntington's disease (HD) have been very important for understanding the cell biology of the disorder and for testing potential therapeutics The recent development of human induced...

Published: 3/13/2025 | Inventor(s): Christopher Ross, Sergey Akimov, Mali Jiang

Keywords(s): Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Ankyrin-G Conditional Forebrain Knockout Mouse Model of Human Psychiatric Disorders

TITLE Ankyrin-G Conditional Forebrain Knockout Mouse Model of Human Psychiatric DisordersCASE NUMBERC13170ABSTRACTThe Ankyrin-G locus has emerged from Genome-Wide Association Studies as one of the risk factors for human psychiatric disorders. It has been positive mainly in studies of bipolar disorder,...

Published: 3/13/2025 | Inventor(s): Christopher Ross, Shanshan Zhu, Vann Bennett

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock Out Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

A Novel Obesity Model: Human Synphilin-1 Transgenic Mouse

Invention novelty: The technology is a transgenic mouse strain (SP1) utilizing synphilin-1 to control food intake and body weight thus providing a convenient model for obesity studies.Value Proposition: The technology provides a unique genetic obesity model for future studies of the pathogenesis of obesity and related disorders.Key features include:-...

Published: 3/13/2025 | Inventor(s): Christopher Ross, Timothy Moran, Wanli Smith

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Metabolic Disorders, Mouse Model, Mouse Model Xenograft, Obesity

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Research Tools

CUG Expressing tg Mice

C11471: Junctophilin 3 (JPH3) Transgenic Mice Expressing Consecutive CUG Triplets Value Proposition: These transgenic mouse models express a short untranslatable fragment of exon 2A of the gene junctophilin 3 (JPH3) containing either 10 or 100 consecutive CUG triplets in the brain. Relevant publication: Rudnicki et al. Huntington's disease-like...

Published: 3/13/2025 | Inventor(s): Lino Tessarollo, Russell Margolis, Christopher Ross, Dobrila Rudnicki

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

iPSCs from Schizophrenia patents with a DISC1 mutation

C11364: Schizophrenia Associated Induced Pluripotent Stem Cell LinesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from somatic cells from members of an American family with schizophrenia and without a schizophrenia diagnosisValue Proposition: Mutations in the Disrupted-in-Schizophrenia 1 (DISC1) gene have been shown to predispose individuals...

Published: 3/13/2025 | Inventor(s): Guo-li Ming, Christopher Ross, Russell Margolis, Hongjun Song

Keywords(s): Basic Research Biomarker, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Schizophrenia, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools

HD-iPSC Lines

C11143: Huntingtons Disease Associated iPSC linesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from patients with Huntingtons disease (HD).Value Proposition: HD is a devastating and fatal hereditary neurodegenerative disorder with no current cure. Although numerous cell culture and animal models exist, the preferential neuron degeneration...

Published: 3/13/2025 | Inventor(s): Guo-li Ming, Russell Margolis, Christopher Ross, Hongjun Song

Keywords(s): Basic Research Biomarker, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Neurodegenerative Diseases, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

PC12 Cell Model of Inducible Expression of Mutant DISC1

C10725: PC12 Stable Cell lines of Inducible Expression of Disrupted in Schizophrenia (DISC1)Value Proposition: JHU inventors have produced neuronal (PC12) cell lines with inducible expression of DISC1. PC12 is a neuronal cell line derived from a pheochromocytoma of the rat brain. This technology includes an inducible Tet-off PC12 cell model with stable...

Published: 3/13/2025 | Inventor(s): Christopher Ross, Mikhail Pletnikov

Keywords(s): Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Rat Cell Lines, Schizophrenia

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools

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