Search Results - christopher+ross

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SCA12 Tools – SCA12 Fibroblasts, iPSCs and Polyclonal Antibodies to Investigate SCA12

Value PropositionFirst in class patient-derived biological tools for investigation of SCA12, a rare neurodegenerative disease with no known cure. Unmet NeedSpinocerebellar ataxia type 12 (SCA12) is a rare neurodegenerative disease that affects the cerebellum, commonly resulting in upper limb tremors and muscle spasms, with some patients reporting a...

Published: 3/13/2026 | Inventor(s): Russell Margolis, Pan Li, Christopher Ross

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Neurology > Neurodegeneration

HDL2 iPSCs

Invention Novelty: Generation of three lines of induced pluripotent stem cells derived from fibroblast cell lines developed from patients with Huntington's disease-like 2.Value Proposition: HDL2, discovered and genetically defined by the Margolis group, is a rare, autosomal dominant neurodegenerative disorder, clinically and neuropathologically...

Published: 3/12/2026 | Inventor(s): Russell Margolis, Christopher Ross, Dobrila Rudnicki, Hongjun Song, Sergey Akimov

Keywords(s): Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Ankyrin-G and Ion Channel Pathway Cell Model for Testing Psychiatric Therapeutics

TITLE Ankyrin-G and Ion Channel Pathway Cell Model for Testing Psychiatric TherapeuticsCASE NUMBERC13171ABSTRACTL-Type calcium channel loci and the Ankyrin-G locus have emerged from Genome-Wide Association Studies as among the major risk factors for human psychiatric disorders, and Johns Hopkins researchers...

Published: 3/12/2026 | Inventor(s): Shanshan Zhu, Christopher Ross

Keywords(s): Cell Signaling, Discovery/Research Tools, In Vitro Research Tool, Molecular Switches/Receptors, Research Reagent, Target-based Screening Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Assays

Multiple Lines of Induced Pluripotent Stem Cells (iPSCs) Derived from Members of an American Family with, and without DISC1 Mutations Associated with Schizophrenia and Depression

Invention Novelty: These tangible materials are induced Pluripotent Stem Cells (iPSCs) derived from members with or without DISC1 (Disrupted in schizophrenia 1) mutations in an American family associated with schizophrenia. Value Proposition:Mutations in DISC1 have been shown to predispose individuals to the development of psychiatric illnesses such...

Published: 3/12/2026 | Inventor(s): Hongjun Song, Christopher Ross, Guo-li Ming, Russell Margolis

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Schizophrenia, Stem Cells, Target-based Screening Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools > Human Cell Lines

A Novel Obesity Model: Human Synphilin-1 Transgenic Mouse

Invention novelty: The technology is a transgenic mouse strain (SP1) utilizing synphilin-1 to control food intake and body weight thus providing a convenient model for obesity studies.Value Proposition: The technology provides a unique genetic obesity model for future studies of the pathogenesis of obesity and related disorders.Key features include:-...

Published: 3/12/2026 | Inventor(s): Christopher Ross, Timothy Moran, Wanli Smith

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Metabolic Disorders, Mouse Model, Mouse Model Xenograft, Obesity

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Metabolic Diseases > Obesity, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Metabolic Diseases, Technology Classifications > Research Tools

CUG Expressing tg Mice

C11471: Junctophilin 3 (JPH3) Transgenic Mice Expressing Consecutive CUG Triplets Value Proposition: These transgenic mouse models express a short untranslatable fragment of exon 2A of the gene junctophilin 3 (JPH3) containing either 10 or 100 consecutive CUG triplets in the brain. Relevant publication: Rudnicki et al. Huntington's disease-like...

Published: 3/12/2026 | Inventor(s): Lino Tessarollo, Russell Margolis, Christopher Ross, Dobrila Rudnicki

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

iPSCs from Schizophrenia patents with a DISC1 mutation

C11364: Schizophrenia Associated Induced Pluripotent Stem Cell LinesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from somatic cells from members of an American family with schizophrenia and without a schizophrenia diagnosisValue Proposition: Mutations in the Disrupted-in-Schizophrenia 1 (DISC1) gene have been shown to predispose individuals...

Published: 3/12/2026 | Inventor(s): Guo-li Ming, Christopher Ross, Russell Margolis, Hongjun Song

Keywords(s): Basic Research Biomarker, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Schizophrenia, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools

HD-iPSC Lines

C11143: Huntingtons Disease Associated iPSC linesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from patients with Huntingtons disease (HD).Value Proposition: HD is a devastating and fatal hereditary neurodegenerative disorder with no current cure. Although numerous cell culture and animal models exist, the preferential neuron degeneration...

Published: 3/12/2026 | Inventor(s): Guo-li Ming, Russell Margolis, Christopher Ross, Hongjun Song

Keywords(s): Basic Research Biomarker, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Neurodegenerative Diseases, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

PC12 Cell Model of Inducible Expression of Mutant DISC1

C10725: PC12 Stable Cell lines of Inducible Expression of Disrupted in Schizophrenia (DISC1)Value Proposition: JHU inventors have produced neuronal (PC12) cell lines with inducible expression of DISC1. PC12 is a neuronal cell line derived from a pheochromocytoma of the rat brain. This technology includes an inducible Tet-off PC12 cell model with stable...

Published: 3/12/2026 | Inventor(s): Christopher Ross, Mikhail Pletnikov

Keywords(s): Basic Research Biomarker, Cell Lines, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Rat Cell Lines, Schizophrenia

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools

Mutant DISC1 Inducible Transgenic Mouse Model of Schizophrenia

C10198: Mutant DISC1 Inducible Transgenic Mouse Model of SchizophreniaValue Proposition: Transgenic mice with inducible expression of mutant human DISC1 (hDISC1) limited to forebrain regions, including cerebral cortex, hippocampus and striatum were generated using the TET-off gene expression system under the regulation of the CAMKII promoter. Expression...

Published: 3/12/2026 | Inventor(s): Christopher Ross, Mikhail Pletnikov

Keywords(s): Clinical Diagnostics, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics, In Vivo Research Tool, Mouse Model, Mouse Model Xenograft, Psychiatric Diseases, Schizophrenia, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools

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