Search Results - knock+in+mouse+model

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TC-1/A2

TITLE: TC-1/A2 cell lineCASE NUMBER: C04953TECHNOLOGYJHU Scientists characterized the ability of DNA-encoding calreticulin linked to DNA-encoding E7 antigen to generate HLA-A2-restricted E7-specific CD8+ T-cell responses in HLA-A2 (AAD) transgenic mice, as well as antitumor effects against an E7+ HLA-A2+ tumor cell line, TC-1/A2.TECHNICAL DETAILSScientists...

Published: 6/27/2024 | Inventor(s): Chien-Fu Hung, T.c. Wu

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

FLT3/ITD Mouse Model for Acute Myeloid Leukemia (AML)

Unmet Need: Constitutive activation of FMS-like tyrosine kinase 3 (FLT3) by internal tandem duplication (ITD) mutations is one of the most common molecular alterations known in acute myeloid leukemia (AML). To investigate the role FLT3/ITD mutations play in the development of leukemia, we generated a FLT3/ITD knock-in mouse model by inserting an ITD...

Published: 6/27/2024 | Inventor(s): Donald Small

Keywords(s): Acute Myeloid Leukemia, Blood Cancer, Cancers, Discovery/Research Tools, Disease Indication, Hematologic Malignancies, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Hematology, Clinical and Disease Specializations > Oncology > Acute Myeloid Leukemia, Clinical and Disease Specializations > Oncology > Hematologic Malignancies, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Conditional mouse model of pseudoxanthoma elasticum (PXE); floxed Abcc6 allele

TITLE: Conditional mouse model of pseudoxanthoma elasticum (PXE); floxed Abcc6 alleleCASE NUMBER: C13613 ABSTRACTUsing ES-cells, JHU researchers generated a PXE conditional mouse model (floxed Abcc6 allele). When bred to a CMV-cre mouse, this mouse develops robust calcification in the vibrissae (snout of the mouse). They use this mouse model to test...

Published: 6/27/2024 | Inventor(s): Harry Dietz, Shira Ziegler

Keywords(s): Basic Research Biomarker, Cardiovascular Diseases, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Cell Lines, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Clinical and Disease Specializations > Cardiovascular

TII2 Flox Mouse Line

ABSTRACTJHU researcher generated mice carrying a targeted deletion of the Tll2 gene. The construct was generated which a LoxP site and a LoxP/neo cassette which were introduced into introns 6 and 7, respectively. Following homologous recombination in embryonic stem cells and transfer of the targeted cells into blastocysts, several chimeric mice were...

Published: 6/27/2024 | Inventor(s): Se-Jin Lee

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Cell Lines, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Pirt-GCaMP3 Mice

Invention novelty: Primary sensory neurons in the DRG play essential role in initiating somatosensory such as pain, itch, and touch by directly sensing various sensory stimuli like mechanical, chemical, and thermal stimuli. Dysfunction of these neurons often leads to various pathological conditions including chronic pain and itch. Currently, no one...

Published: 6/27/2024 | Inventor(s): Xinzhong Dong

Keywords(s): Basic Research Biomarker, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vivo Research Tool, Itch, Knock In Mouse Model, Mouse Model, Neuropathy

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Neurology > Itch, Clinical and Disease Specializations > Neurology > Neuropathy

Fibrillin 1 Mutant Mice (W1572C Mutant Strain) and (D1545E Mutant Strain)

TITLE: Fibrillin 1 Mutant Mice (W1572C Mutant strain) and (D1545E Mutant Strain)CASE NUMBER: C13499ABSTRACTFibrillin1 D1545E Mutant StrainThese mice carry a D1545E mutation in the mouse Fbn1 gene and serve as a model of human stiff skin syndrome with increased collagen deposition in the dermis, decreased subcutaneous fat, and circulating anti-nuclear...

Published: 6/27/2024 | Inventor(s): Harry Dietz, Elizabeth Gerber

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Cell Lines, Mouse Model, Skin Disorders, Translational Research Biomarker

RL12, RL1, RL13, RL2 Monoclonal Antibodies

TITLERL12, RL1, RL13, RL2 Monoclonal AntibodiesCASE NUMBERC03099ABSTRACTRL1, mouse monoclonal IgM that recognizes a group of eight O-linked glycoproteins of the nuclear pore complex, is a specific marker for the nuclear pore complex in species from yeast to humans; RL2, mouse monoclonal antibody that recognizes O-linked N-acetylglucosamine on a large...

Published: 6/27/2024 | Inventor(s): Larry Gerace

Keywords(s): Antibodies, Basic Research Biomarker, Biologics, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Monoclonal Antibodies, Mouse Model, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Antibodies, Technology Classifications > Therapeutic Modalities > Antibodies, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

Targeted Gfp Knock-in to the Islr2 (aka Linx) Locus

Linx Null Mouse ModelsJHU REF: C12483Invention novelty: This tangible material includes linx (Islr2) null mouse strain generated by the knock-in of targeted Gfp in the linx locus. Value Proposition:Linx mutant mouse strain.Technical Details:Johns Hopkins researchers have developed a linx null mouse strain. This was done in order to assess the in vivo...

Published: 6/27/2024 | Inventor(s): Kenji Mandai, David Ginty

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Model, Neurons, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models

Alpha 2 Collagen VIII (Col8a2) L450W Knock-in Mouse Model of Fuchs Endothelial Corneal Dystrophy

Alpha 2 Collagen VIII (Col8a2) L450W Knock-in Mouse Model of Fuchs Endothelial Corneal DystrophyJHU REF: C13003Invention novelty: This tangible material is an Alpha 2 collagen VIII (Col8a2) L450W knock-in mouse model of Fuchs endothelial corneal dystrophy (FECD)Value PropositionFuchs endothelial corneal dystrophy (FECD) is a progressive, hereditary...

Published: 6/27/2024 | Inventor(s): Albert Jun

Keywords(s): Basic Research Biomarker, Corneal Dystrophy, Discovery/Research Tools, Disease Indication, Eye Disorders, Fuchs' Endothelial Corneal Dystrophy, Fuchs Endothelial Corneal Dystrophy (FECD), In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ophthalmology > Corneal Dystrophy, Clinical and Disease Specializations > Ophthalmology > Fuchs' Endothelial Corneal Dystrophy, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Animal Models, Clinical and Disease Specializations > Ophthalmology, Technology Classifications > Research Tools

Opn4(superscript: tauLacZ/+) Knock-in Mice

TITLE Opn4tauLacZ/+ Knock-in MiceCASE NUMBER: C13016ABSTRACTThe primary circadian pacemaker, in the suprachiasmatic nucleus (SCN) of the mammalian brain, is photoentrained by light signals from the eyes through the retinohypothalamic tract. Retinal rod and cone cells are not required for photoentrainment....

Published: 6/27/2024 | Inventor(s): King-Wai Yau, Samer Hattar

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

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