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Targeted Gfp Knock-in to the Islr2 (aka Linx) Locus

Value Proposition· Genetically modified mouse model with targeted GFP knock-in to the Islr2/Linx locus, enabling real-time visualization of specific neuronal populations during critical developmental windows· Dual functionality - the null mutation eliminates Linx protein to reveal functional defects (shorter, thinner nerves and stalled branching),...

Published: 10/23/2025 | Inventor(s): Kenji Mandai, David Ginty

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Model, Neurons, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Animal Models