Search Results - neurons

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Immortalization of Nociceptive Dorsal Root Ganglion Sensory Neurons

Unmet need This invention involves a novel method to immortalize Nociceptive dorsal root ganglion (DRG) neurons. DRG neurons are terminally differentiated cells that extend long axons to their target tissues. More than half of all DRG neurons are unmyelinated axons that extend to the skin and have nociceptive properties. In many studies on peripheral...

Published: 3/13/2025 | Inventor(s): Weiran Chen, Ahmet Hoke

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Cultured Networks of Excitatory Projection Neurons and Inhibitory Interneurons for Studying Human Cortical Neurotoxicity

Unmet Need: Translating neuroprotective treatments from discovery in cell and animal models to the clinic has proven challenging. To reduce the gap between basic studies of neurotoxicity and neuroprotection and clinically relevant therapies, JHU scientists developed a human cortical neuron culture system from human embryonic stem cells or human inducible...

Published: 3/13/2025 | Inventor(s): Ted Dawson, Valina Dawson, Jinchong Xu, Jing Fan

Keywords(s): Antagonists/Inhibitors, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Small Molecules, Stroke, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

Targeted Gfp Knock-in to the Islr2 (aka Linx) Locus

Linx Null Mouse ModelsJHU REF: C12483Invention novelty: This tangible material includes linx (Islr2) null mouse strain generated by the knock-in of targeted Gfp in the linx locus. Value Proposition:Linx mutant mouse strain.Technical Details:Johns Hopkins researchers have developed a linx null mouse strain. This was done in order to assess the in vivo...

Published: 3/13/2025 | Inventor(s): Kenji Mandai, David Ginty

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, In Vivo Research Tool, Knock In Mouse Model, Mouse Model, Neurons, Translational Research Biomarker

GN11cells

C11373: GN11 cells: gonadotropin-releasing hormone (GnRH) expressing cell lines. Value Proposition: This technology involves GN11 cells obtained from a tumor in mice containing a transgene consisting of a human GnRH promoter fused to the SV40 Large TAntigen oncogene (Tag). GN11 cells are immortalized, gonadotropin-releasing hormone (GnRH) expressing...

Published: 3/13/2025 | Inventor(s): Sally Radovick

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Mouse Cell Lines, Neurons

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

A High Throughput Screen Utilizing Newly Discovered Intramolecular Neuronal Calcium Channel interactions to Discover New Analgesics

Unmet NeedChronic pain management continues to be a medical and public health imperative. N-type calcium channel blockers, such as FDA approved Prialt® (ziconotide), have been found to have analgesic effects (blocking pain signals from the nerves to the brain) and to work synergistically with opioids. Unfortunately, drugs like Prialt have serious adverse...

Published: 3/13/2025 | Inventor(s): Heather Agler, David Yue

Keywords(s): Basic Research Biomarker, Cell Model, Chronic Pain, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Target-based Screening Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Pain > Chronic Pain, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Pain

SynGAP

C03367: SynGAP Technical Details: The PSD-95/SAP90 family of proteins have recently been implicated in the organization of synaptic structure. Here we describe the isolation of a novel ras-GTPase activating protein, GAPSYN, that specifically interacts with the PDZ domains of PSD-95 and SAP102 in vitro and in vivo. GAPSYN is selectively expressed...

Published: 3/13/2025 | Inventor(s): Richard Huganir, Jee-Hae Kim

Keywords(s): Cell Model, Cell Signaling, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Molecular Switches/Receptors, Neurons, Research Reagent, Translational Research Biomarker