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Cultured Networks of Excitatory Projection Neurons and Inhibitory Interneurons for Studying Human Cortical Neurotoxicity

Unmet Need: Translating neuroprotective treatments from discovery in cell and animal models to the clinic has proven challenging. To reduce the gap between basic studies of neurotoxicity and neuroprotection and clinically relevant therapies, JHU scientists developed a human cortical neuron culture system from human embryonic stem cells or human inducible...

Published: 3/13/2025 | Inventor(s): Ted Dawson, Valina Dawson, Jinchong Xu, Jing Fan

Keywords(s): Antagonists/Inhibitors, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Small Molecules, Stroke, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities