Search Results - stroke

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Novel Therapeutic Target for Neural Regeneration, Stroke and Anti-depressants

Unmet needCurrent anti-depressants in the market have various limitations including lack of broad-spectrum drugs, unexpected side effects, toxicity and low efficacy for certain patients. New generation of anti-depressants based on most recent biomedical discoveries concerning depression are urgently needed. Technology overviewJohns Hopkins researchers...

Published: 3/13/2025 | Inventor(s): Dengke Ma, Guo-li Ming, Hongjun Song

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Mechanism of Action Biomarker, Psychiatric Diseases, Stroke, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Stroke, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Targets

Cultured Networks of Excitatory Projection Neurons and Inhibitory Interneurons for Studying Human Cortical Neurotoxicity

Unmet Need: Translating neuroprotective treatments from discovery in cell and animal models to the clinic has proven challenging. To reduce the gap between basic studies of neurotoxicity and neuroprotection and clinically relevant therapies, JHU scientists developed a human cortical neuron culture system from human embryonic stem cells or human inducible...

Published: 3/13/2025 | Inventor(s): Ted Dawson, Valina Dawson, Jinchong Xu, Jing Fan

Keywords(s): Antagonists/Inhibitors, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Neurons, Small Molecules, Stroke, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Therapeutic Modalities > Small Molecules, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

CADENCE Balloon Shunt

CADENCE is a novel, patented treatment platform that functions to alter cerebrospinal fluid (CSF) flow, increase cerebral blood flow (CBF), and modulate the intracranial pressure (ICP) wave through natural cardiac-induced dynamics. CADENCE can be visualized as an intra-aortic balloon pump for the brain and therefore functionally very distinct from...

Published: 3/13/2025 | Inventor(s): Mark Luciano

Keywords(s): CNS and Neurological Disorders, Disease Indication, Implanted Device, Implants, Stent, Stroke, Therapeutic Devices, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Medical Devices > Therapeutic Devices, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Neurology

Patient-Specific Virtual Intervention Laboratory to Prevent Stroke

Atrial fibrillation (AF), the most common human arrhythmia, is a marker of an increased risk of embolic stroke. However, recent studies suggest that AF may not be mechanistically responsible for the stroke events. An alternative explanation for the mechanism of intracardiac thrombosis and stroke in patients with AF is structural remodeling of the left...

Published: 3/13/2025 | Inventor(s): Hiroshi Ashikaga, Tomohiro Otani

Keywords(s): CNS and Neurological Disorders, Disease Indication, Disease Management System, Healthcare Management, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Operations Management, Stroke

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Neurology

System and Method For Blood Brain Permeability Imaging (BBPI) Using Dynamic Susceptibility Contrast Magnetic Resonance Imaging

Description:The blood-brain barrier (BBB) plays a critical role in both normal function and pathological states of the brain. While disruption of the BBB can be a hallmark of disease activity, the BBB also serves as a barrier to drug delivery. Thus, imaging the BBB has innumerable applications. Previous attempts to image the BBB have not been sensitive...

Published: 3/13/2025 | Inventor(s): Peter Barker, Richard Leigh

Keywords(s): CNS and Neurological Disorders, Disease Indication, Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Stroke

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Neurology

Measurement of Blood Volume using Velocity-Selective Pulse Trains on MRI

INVENTION NOVELTY A novel velocity-selective inversion pulse sequence that can be used for MR angiography applications. VALUE PROPOSITION There is a growing demand for high–performance imaging that is beneficial in cases where 1.5 Tesla does not work well enough, such as scanning for developmental abnormalities or performing high–resolution MR angiography,...

Published: 3/13/2025 | Inventor(s): Qin Qin

Keywords(s): CNS and Neurological Disorders, Disease Indication, Distortion Elimination Software, Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Integrated Imaging System, Interventional and Surgical Systems, Magnetic Resonance Imaging (MRI), Stroke, Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis

Augmentation of Endocardial Thromboresistance

C04927: Augmentation of Endocardial Thromboresistance Technical Details: A critical function of the endocardium is to maintain local thromboresistance by providing an anticoagulant surface. Thrombomodulin, is expressed on the surface of the endocardium endothelial cells and is the key component of the anticoagulant protein C pathway, and thus is critical...

Published: 3/13/2025 | Inventor(s): Navin Kapur, Jeffrey Rade

Keywords(s): Biologics, Cardiovascular Diseases, Cell Therapy, CNS and Neurological Disorders, Disease Indication, Protein, Single, Stroke, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Therapeutic Modalities > Cell Therapies, Clinical and Disease Specializations > Neurology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Clinical and Disease Specializations > Cardiovascular