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3D Shell MEAs for Electrically Active Organoids

Value Proposition· 3D shell MEAs is a novel platform for encapsulation, electrical stimulation, and recording of organoids· Electrophysiological measurements of electrically active 3D organoids. · Relevant to brain development, neurological disorders, drug screening; neuromorphic computing and brain-machine interfaces; and organoid...

Published: 6/28/2024 | Inventor(s): David Gracias, Lena Smirnova, Qi Huang

Keywords(s):

Category(s): Clinical and Disease Specializations > Autoimmunity, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Motor Neuron Diseases, Clinical and Disease Specializations > Neurology > Multiple Sclerosis, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Neurology > Neuropathy, Technology Classifications, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Research Stem Cells

Upgrading Carbon Fiber and Harvesting Hydrogen from Methane Pyrolysis

Unmet Need:Carbon fibers are a highly desirable material in a variety of applications such as for aerospace and military due to their light weight and strong mechanical properties. Among commercially produced carbon fibers, polyacrylonitrile (PAN)-based ones make up the vast majority of the market owing to its superior performance. However, current...

Published: 6/28/2024 | Inventor(s): Chao Wang, Canhui Wang, Pengfei Xie, Liangbing Hu, Satish Kumar, Tangyuan Li, Qi Dong, Pedro Arias-Monje, Bodiuzzaman Jony, Kishor Gupta

Keywords(s):

Category(s): Technology Classifications > Engineering Tech, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Energy, Infrastructure & Environment

Non-immunosuppressive FK506 analogs and use thereof

Unmet NeedChronic, nonhealing wounds are estimated to affect approximately 2% of the general population, and the cost of caring for these wounds exceeds $50 billion per year. These costs are expected to rise due to the increasing prevalence of diabetes and other diseases that hinder wound healing. Chronic infections increase morbidity and mortality...

Published: 6/28/2024 | Inventor(s): Jun Liu, Zhaoli Sun, Brandon Peiffer, Yuefan Wang, Le Qi, Zufeng Guo, Hanjing Peng, Ali Ahmadi

Keywords(s): Antagonists/Inhibitors, Combination, Disease Indication, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutic Substance Synthesis Method, Therapeutics, Therapy Type, Transplants

Category(s): Clinical and Disease Specializations > Wound Healing, Technology Classifications > Therapeutic Modalities > Small Molecules

Measurement of Blood Volume using Velocity-Selective Pulse Trains on MRI

INVENTION NOVELTY A novel velocity-selective inversion pulse sequence that can be used for MR angiography applications. VALUE PROPOSITION There is a growing demand for high–performance imaging that is beneficial in cases where 1.5 Tesla does not work well enough, such as scanning for developmental abnormalities or performing high–resolution MR angiography,...

Published: 6/27/2024 | Inventor(s): Qin Qin

Keywords(s): CNS and Neurological Disorders, Disease Indication, Distortion Elimination Software, Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Integrated Imaging System, Interventional and Surgical Systems, Magnetic Resonance Imaging (MRI), Stroke, Surgical Navigation

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Stroke, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Neurology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis

Velocity Selective Pulses with Arbitrary Shape

C12796 NOVEL PULSE SEQUENCE FOR NON-CONTRAST ENHANCED MRIInvention novelty: A novel velocity-selective inversion pulse sequence that can be used for MR angiography applications.Value Proposition:There is a growing demand for high–performance imaging that is beneficial in cases where 1.5 Tesla does not work well enough, such as scanning for developmental...

Published: 6/27/2024 | Inventor(s): Peter van Zijl, Qin Qin

Keywords(s): Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Biomarkers of Myocardial Injury

C12557: CARDIAC INJURY DIAGNOSTIC BIOMARKERSInvention novelty: Biomarkers identified for accurate and differential diagnosis and prognosis of cardiac injury and associated delayed adverse event related risksValue Proposition: Currently, various tests have been used to detect myocardial events. The clinically available tests include assays for measuring...

Published: 6/27/2024 | Inventor(s): Qin Fu, Jennifer Van Eyk, Vidya Venkatraman

Keywords(s): Biomarker, Cardiovascular Diseases, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Myocardial Infarction, Myocardial Infarction (MI)

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Cardiovascular > Myocardial Infarction, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Cardiovascular, Technology Classifications > Diagnostics

Functional magnetic resonance imaging (fMRI) methodology using transverse relaxation preparation and non- echo-planar-imaging (EPI) pulse sequences

C12282: Enhanced Whole Brain fMRINovelty: This invention is a method to mitigate geometric distortion and signal dropout when performing whole brain imaging by blood-oxygenation-level-dependent fMRI.Value Proposition: Current approaches to blood-oxygenation-level-dependent (BOLD) fMRI rely on 2D gradient echo (GRE) echo-planar-imaging (EPI), and are...

Published: 6/27/2024 | Inventor(s): Peter van Zijl, Craig Jones, Qin Qin, Jun Hua

Keywords(s): Cancers, CNS and Neurological Disorders, Diabetes, Disease Indication, Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Inflammatory Disorders, Magnetic Resonance Imaging (MRI), Metabolic Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Metabolic Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Chloroquine-induced Itch is Mediated by Mrgs

C10519: Methods and Compositions for Treating Itch Value Proposition: Inventors have identified a cell receptor family known as Mrgprs that is exclusively expressed in a small subset of neurons. In vitro and animal studies suggest that the Mrg receptor family directly mediates chloroquine (CQ) induced itch. Identification and characterization of Mrgprs...

Published: 6/27/2024 | Inventor(s): David Anderson, Qin Liu, Xinzhong Dong

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Infectious Diseases, Inflammatory Disorders, Itch, Malaria, Mechanism of Action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Inflammation, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Infectious Diseases > Malaria, Clinical and Disease Specializations > Neurology > Itch

Biomarkers of Myocardial Ischemia

C10179: Biomarkers of Myocardial IschemiaValue Proposition: Detection of ischemic myocardium as an early indication of cardiac injury allowing early detection of myocardial infarction and cell death.Technical Details: Coronary heart disease is the most common single cause of death in the western world representing ~20% of all deaths. This is equivalent...

Published: 6/27/2024 | Inventor(s): Qin Fu, Simon Sheng, Jennifer Van Eyk

Keywords(s): Biomarker, Cardiovascular Diseases, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Myocardial Infarction, Myocardial Infarction (MI)