Search Results - peter+van+zijl

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Novel CEST MRI-suitable Reporter Genes to Non-Invasively Monitor Distribution and Migration of Biotherapeutics

Unmet NeedGreen Fluorescent Protein (GFP) reporter genes and PET (positron-emission tomography) imagining are two techniques which have been widely used to monitor the movement and distribution of specific molecules in cells or animals. Imaging GFP-tagged molecules is often destructive to the sample and is limited by the degree that light can penetrate...

Published: 9/26/2024 | Inventor(s): Assaf Gilad, Michael Mcmahon, Paul Winnard, Venu Raman, Jeff Bulte, Peter van Zijl

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

Magnetic Resonance Method for Imaging Molecular Binding with Enhanced Sensitivity

Unmet Need: The binding affinity of a drug for its target is perhaps the most essential parameter when assessing drug efficacy, however it is often calculated in vitro within purified systems, which do not accurately represent patient-specific kinetics. More recently, strategies have been developed for chemically labeling compounds and their targets,...

Published: 9/26/2024 | Inventor(s): Peter van Zijl, Nirbhay Yadav

Keywords(s): Image Processing Software, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Tracking Software

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics > In Vitro Diagnostics

FREQUENCY REFERENCING METHOD FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) MRI.

Unmet Need: Chemical exchange saturation transfer (CEST) imaging is a relatively new contrast mechanism for MRI exploiting exchange-based magnetization transfer (MT) between solute and water protons. Although it has huge potential for developing noninvasive agents for cell labeling and other applications, when applying the method in vivo or even in...

Published: 9/26/2024 | Inventor(s): Mina Kim, Joseph Gillen, Peter van Zijl

Keywords(s): Image Display Software, Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Computers, Electronics & Software, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

Method of Assessing Tissue Vascular Permeability Using Non-labeled Dextran Detected by MRI

Novel Strategy to Assess Vascular Permeability for Nanoparticle TherapyJHU REF: C12886Invention Novelty: Use of dextran to assess target tissue vascular permeability and clearance of nanoparticles of various sizes for clinical diagnosis and assessment of appropriate nanoparticle treatment of cancer and other diseases.Value Proposition:Development of...

Published: 9/26/2024 | Inventor(s): Yuguo Li, Peter van Zijl, Guanshu Liu

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Drug Delivery Vehicle, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vitro Diagnostics, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Nanoparticles, Pharmakodynamic Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Use of non-labeled antimetabolites and analogs thereof as theranostic agents

Use of non-labeled antimetabolites as cancer theranostic agents JHU REF: C12878Invention Novelty: This technology is a method and a system of using non-labeled antimetabolites (purine-, pyrimidine- and folate- based) and their analogs as theranostic agents with MRI imaging.Value Proposition:Imaging drug delivery is of great clinical importance. Achieving...

Published: 9/26/2024 | Inventor(s): Peter van Zijl, Yuguo Li, Shibin Zhou, Bert Vogelstein, Guanshu Liu

Keywords(s): Cancers, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

Velocity Selective Pulses with Arbitrary Shape

C12796 NOVEL PULSE SEQUENCE FOR NON-CONTRAST ENHANCED MRIInvention novelty: A novel velocity-selective inversion pulse sequence that can be used for MR angiography applications.Value Proposition:There is a growing demand for high–performance imaging that is beneficial in cases where 1.5 Tesla does not work well enough, such as scanning for developmental...

Published: 9/26/2024 | Inventor(s): Peter van Zijl, Qin Qin

Keywords(s): Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

CEST Substrates

C12412: New Reporter System for CEST MRINovelty: Novel reporter system for chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) without paramagnetic metal substrates.Value Proposition: Among the clinically applied 3D imaging modalities, MRI has the highest resolution and is therefore the preferred method for detection of cellular...

Published: 9/26/2024 | Inventor(s): Jeff Bulte, Guanshu Liu, Raag Airan, Michael Mcmahon, Peter van Zijl, Amnon Bar-Shir, Assaf Gilad

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Technology Classifications > Computers, Electronics & Software > Sensors

Magnetic Resonance Pulse Sequence for Detecting the Buildup of the Transfer of Changes in Magnetization from Nuclei in Mobile Solute Molecules in Tissue

C12354: Method to Improve CEST MRI AcquisitionsNovelty: Magnetic resonance imaging (MRI) pulse sequence for detecting the buildup of the transfer of magnetization changes from nuclei in mobile solute molecules in tissue.Value Proposition: Chemical Exchange Saturation Transfer (CEST) imaging is a new MR imaging approach that allows for the detection...

Published: 9/26/2024 | Inventor(s): Peter van Zijl, Nirbhay Yadav, Jiadi Xu

Keywords(s): Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Functional magnetic resonance imaging (fMRI) methodology using transverse relaxation preparation and non- echo-planar-imaging (EPI) pulse sequences

C12282: Enhanced Whole Brain fMRINovelty: This invention is a method to mitigate geometric distortion and signal dropout when performing whole brain imaging by blood-oxygenation-level-dependent fMRI.Value Proposition: Current approaches to blood-oxygenation-level-dependent (BOLD) fMRI rely on 2D gradient echo (GRE) echo-planar-imaging (EPI), and are...

Published: 9/26/2024 | Inventor(s): Peter van Zijl, Craig Jones, Qin Qin, Jun Hua

Keywords(s): Cancers, CNS and Neurological Disorders, Diabetes, Disease Indication, Image Processing Software, Image Reconstruction Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Inflammatory Disorders, Magnetic Resonance Imaging (MRI), Metabolic Disorders

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Diabetes, Clinical and Disease Specializations > Inflammation, Clinical and Disease Specializations > Metabolic Diseases, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology, Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Non-invasive Temperature Mapping Using Temperature-responsive Water Saturation Shift Referencing (T-WASSR) MRI

C12084: MRI Thermal ImagingNovelty: This technology is a novel, non-invasive procedure for temperature mapping of tissues regardless of fat content.Value Proposition: The use of hyperthermia devices and treatments is becoming increasingly popular for the purpose of treating cancer without radiation, chemotherapy drugs, or invasive surgery. These technologies...

Published: 9/26/2024 | Inventor(s): Guanshu Liu, Assaf Gilad, Michael Mcmahon, Peter van Zijl

Keywords(s): Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

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