Search Results - imaging+agent

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Method for Labeling, Purifying, Enriching and Magnetic Resonance Imaging of Extracellular Vesicles Using Surface-functionalized Magnetic Particles

Unmet NeedExtracellular vesicles (EVs) are membrane structures that are naturally occurring and act as carriers for DNA, RNA, or nutrients. Recently EVs have also been looked at as potential drug delivery systems or carriers of biomarkers for particular diseases. MRI is a non-invasive method to image EVs and study their movement and distribution throughout...

Published: 6/20/2024 | Inventor(s): Guanshu Liu, Zheng Han

Keywords(s): Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, In Vivo Research Tool

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging

PSMA-Targeted PAMAM Dendrimers for Specific Delivery of Imaging, Contrast and Therapeutic Agents

Unmet NeedAccording to The American Cancer Society, approximately 1 in 9 men will be diagnosed with prostate cancer in their lifetime, with 174,650 new cases diagnosed yearly in the US. As prostate cancer is the second leading cause of cancer death in American men, early detection is important for adequate treatment. The most common method of detecting...

Published: 6/20/2024 | Inventor(s): Martin Pomper, Wojciech Lesniak, Srikanth Boinapally, Sangeeta Ray, Catherine Foss

Keywords(s): Cancers, Dendrimers, Disease Indication, Drug Delivery Vehicle, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Prostate Cancer, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices > Imaging

11C-PABA as a Novel Functional Renal Imaging Agent

Unmet Need: Assessing kidney function is often essential for clinical decision making for a variety of diseases including chronic kidney disorder (CKD). CKD affects more than 30 million Americans and millions of others are at an increased risk of developing it. The gold standard for measuring renal function for diagnosing/monitoring CKD and other disorders...

Published: 6/20/2024 | Inventor(s): Sanjay Jain, Alvaro Ordonez, Camilo Ruiz-Bedoya

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Kidney Disorders, Positron Emission Tomography (PET)

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging, Clinical and Disease Specializations > Nephrology

New fluorinated DREADD actuators and ligands suitable for PET imaging

Unmet NeedChemogenetics is defined as a method by which proteins are made to interact with small molecules, typically neurological molecules, as they have never been interacted with before. There is a powerful and versatile approach for remote and momentary manipulation of cellular activity called Designer Receptors Exclusively Activated by Designer...

Published: 6/20/2024 | Inventor(s): Andrew Horti, Martin Pomper, Michael Michaelides, Jordi Bonaventura, Feng Hu, Juan Luis Gomez, Marta Sanchez-Soto

Keywords(s): Biologics, Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Labels/Markers, Radioisotope Therapy, Research Reagent, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools > Proteins, Ligands & Receptors

Competitive PSMA Binding Agents for Reduction of Non-target Organ Uptake of Radiolabeled PSMA Inhibitors for PSMA Positive Tumor Imaging and Radiopharmaceutical Therapy

Unmet NeedProstate cancer is the second leading cause of cancer related death in American men and it is estimated that approximately 164,690 new cases will be diagnosed in 2018. Elevated prostate-specific membrane antigen (PSMA) serves as a biomarker for prostate cancer and as well as primary clear cell renal carcinoma (ccRCC). However, PSMA is also...

Published: 6/20/2024 | Inventor(s): Martin Pomper, Ronnie Mease, Sangeeta Ray, Il Minn

Keywords(s): Cancers, Combination, Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Prostate Cancer, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type

Category(s): Clinical and Disease Specializations > Oncology > Prostate Cancer, Clinical and Disease Specializations > Men's Health, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Therapeutic Modalities > Targets

Novel CEST MRI-suitable Reporter Genes to Non-Invasively Monitor Distribution and Migration of Biotherapeutics

Unmet NeedGreen Fluorescent Protein (GFP) reporter genes and PET (positron-emission tomography) imagining are two techniques which have been widely used to monitor the movement and distribution of specific molecules in cells or animals. Imaging GFP-tagged molecules is often destructive to the sample and is limited by the degree that light can penetrate...

Published: 6/20/2024 | Inventor(s): Assaf Gilad, Michael Mcmahon, Paul Winnard, Venu Raman, Jeff Bulte, Peter van Zijl

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices

Endoscopic Accessory for Indocyanine Green (ICG)-Based Biliary Imaging during ERCP

Unmet NeedThe Endoscopic Retrograde Cholangiopancreatography (ERCP) procedure is used to perform therapies such as retrieving obstructing gallstones, expanding tissue strictures, or placing a stent to relieve obstruction from malignancies. The procedure requires precision and a high degree of technical skill. For physicians to perform the procedure...

Published: 6/20/2024 | Inventor(s): Marc Chelala, Sritam Rout, Maria Torres, Kyle Cowdrick, Amir Soltanianzadeh, David Gullotti, Pankaj Pasricha, Nicholas Durr

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Pancreatic Disorders, Pancreatitis

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Medical Devices > Imaging, Clinical and Disease Specializations > Inflammation, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Inflammation > Pancreatitis

Anastasis Biosensor CaspaseTracker rtTA

Anastasis Biosensor CaspaseTracker rtTA – C15014 Unmet NeedAnastasis, Greek for "rising to life", is a newly discovered cell recovery phenomenon by which a cell undergoes reversal of apoptosis or programmed cell death. Research has shown that even cells that exhibit the hallmarks of late-stage cell death such as activation of executioner caspases...

Published: 6/20/2024 | Inventor(s): Ho Lam Tang, Ho Man Holly Tang

Keywords(s): Animal Imaging Tools, apoptosis, Biomarker, Clinical Diagnostics, Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vitro Diagnostics, In Vivo Medical Imaging, In Vivo Research Tool, Labels/Markers, Research Reagent

Category(s): Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics > Biomarkers

Magnetic Resonance Method for Imaging Molecular Binding with Enhanced Sensitivity

Unmet Need: The binding affinity of a drug for its target is perhaps the most essential parameter when assessing drug efficacy, however it is often calculated in vitro within purified systems, which do not accurately represent patient-specific kinetics. More recently, strategies have been developed for chemically labeling compounds and their targets,...

Published: 6/20/2024 | Inventor(s): Peter van Zijl, Nirbhay Yadav

Keywords(s): Image Processing Software, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Tracking Software

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics > In Vitro Diagnostics

Particulate Drug Delivery System to Enable Targeted Ultrasound-gated Release of Neuromodulatory Agents

Targeted, noninvasive neuromodulation of the brain of an otherwise awake subject could revolutionize both basic and clinical neuroscience. Towards this goal, the JHU scientists have developed nanoparticles that allow noninvasive uncaging of a neuromodulatory drug upon the application of focused ultrasound. These nanoparticles are composed of biodegradable...

Published: 6/20/2024 | Inventor(s): Jordan Green, Raag Airan, Randall Meyer

Keywords(s): CNS and Neurological Disorders, Disease Indication, Drug Delivery Mechanism, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Nerve Disorders and Injury, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms, Technology Classifications > Medical Devices, Technology Classifications > Therapeutic Modalities, Technology Classifications > Medical Devices > Neurostimulation

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