Search Results - guanshu+liu

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Method for Labeling, Purifying, Enriching and Magnetic Resonance Imaging of Extracellular Vesicles Using Surface-functionalized Magnetic Particles

Unmet NeedExtracellular vesicles (EVs) are membrane structures that are naturally occurring and act as carriers for DNA, RNA, or nutrients. Recently EVs have also been looked at as potential drug delivery systems or carriers of biomarkers for particular diseases. MRI is a non-invasive method to image EVs and study their movement and distribution throughout...

Published: 6/27/2024 | Inventor(s): Guanshu Liu, Zheng Han

Keywords(s): Discovery/Research Tools, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, In Vivo Research Tool

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging

Method of Assessing Tissue Vascular Permeability Using Non-labeled Dextran Detected by MRI

Novel Strategy to Assess Vascular Permeability for Nanoparticle TherapyJHU REF: C12886Invention Novelty: Use of dextran to assess target tissue vascular permeability and clearance of nanoparticles of various sizes for clinical diagnosis and assessment of appropriate nanoparticle treatment of cancer and other diseases.Value Proposition:Development of...

Published: 6/27/2024 | Inventor(s): Yuguo Li, Peter van Zijl, Guanshu Liu

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, Drug Delivery Vehicle, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vitro Diagnostics, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Nanoparticles, Pharmakodynamic Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Diagnostics, Technology Classifications > Medical Devices, Technology Classifications > Diagnostics > In Vivo Diagnostics, Technology Classifications > Therapeutic Modalities > Therapeutic Delivery Platforms

Use of non-labeled antimetabolites and analogs thereof as theranostic agents

Use of non-labeled antimetabolites as cancer theranostic agents JHU REF: C12878Invention Novelty: This technology is a method and a system of using non-labeled antimetabolites (purine-, pyrimidine- and folate- based) and their analogs as theranostic agents with MRI imaging.Value Proposition:Imaging drug delivery is of great clinical importance. Achieving...

Published: 6/27/2024 | Inventor(s): Peter van Zijl, Yuguo Li, Shibin Zhou, Bert Vogelstein, Guanshu Liu

Keywords(s): Cancers, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

CEST Substrates

C12412: New Reporter System for CEST MRINovelty: Novel reporter system for chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) without paramagnetic metal substrates.Value Proposition: Among the clinically applied 3D imaging modalities, MRI has the highest resolution and is therefore the preferred method for detection of cellular...

Published: 6/27/2024 | Inventor(s): Jeff Bulte, Guanshu Liu, Raag Airan, Michael Mcmahon, Peter van Zijl, Amnon Bar-Shir, Assaf Gilad

Keywords(s): Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Technology Classifications > Computers, Electronics & Software > Sensors

Non-invasive Temperature Mapping Using Temperature-responsive Water Saturation Shift Referencing (T-WASSR) MRI

C12084: MRI Thermal ImagingNovelty: This technology is a novel, non-invasive procedure for temperature mapping of tissues regardless of fat content.Value Proposition: The use of hyperthermia devices and treatments is becoming increasingly popular for the purpose of treating cancer without radiation, chemotherapy drugs, or invasive surgery. These technologies...

Published: 6/27/2024 | Inventor(s): Guanshu Liu, Assaf Gilad, Michael Mcmahon, Peter van Zijl

Keywords(s): Image Processing Software, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Computers, Electronics & Software > Image Processing & Analysis, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Medical Devices

Use of Non-labeled Infusion of Natural Sugars and Detection by MRI for Assessing Tissue Perfusion and Metabolism

C11306: Use of Non-labeled Sugars in MRIValue Proposition: ADVANTAGES:• Provides an alternative approach to measure MR contrast sensitive to both metabolic and vascular properties (perfusion and permeability) of tissue. • Uses a natural biodegradable compound that is already available in the clinic, without the need for paramagnetic, magnetic,...

Published: 6/27/2024 | Inventor(s): Guanshu Liu, Dmitri Artemov, Yoshinori Kato, Kannie Chan, Michael Mcmahon, Peter van Zijl

Keywords(s): Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI), Wound Healing

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Wound Healing, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices