Search Results - shibin+zhou

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Use of Bacteria, Bacterial Products, and other Immunoregulatory Entities in Combination with Anti-CTLA-4 and/or Anti-PD-1 Antibodies to Treat Solid Tumor Malignancies

Combined Therapeutic Method for Solid TumorJHU REF: [C12570]Invention novelty: This technology is a combination therapy method including a tumor-specific bacterium and antibodies that boost tumor immune response.Value PropositionWorldwide cancer affects more than 12 million people each year. This number is expected to increase to 14 million each year...

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Bert Vogelstein, KiBem Kim, Shibin Zhou

Keywords(s): Antibodies, Biologics, Cancers, Combination, Disease Indication, Immunotherapy/ Immunotherapy, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Whole cell

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Cell Therapies, Technology Classifications > Therapeutic Modalities > Immunotherapies

Imaging Bacteria with Light-emitting Substrates of Thymidine Kinase

The instant invention provides a method for diagnosing an infection in a subject by administering to the subject a compound suitable for imaging which binds to a thymidine kinase present in the infecting organism, and obtaining an image of the subject to determine the presence and location of the compound, wherein a localization of the compound is indicative...

Published: 6/27/2024 | Inventor(s): Catherine Foss, Bert Vogelstein, Shibin Zhou, Kenneth Kinzler, Chetan Bettegowda, Martin Pomper

Keywords(s): Discovery/Research Tools, Labels/Markers, Non-novel, Off-the-shelf, Predicted Novelty, Research Reagent, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Technology Classifications > Diagnostics > Diagnostic Imaging, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Use of non-labeled antimetabolites and analogs thereof as theranostic agents

Use of non-labeled antimetabolites as cancer theranostic agents JHU REF: C12878Invention Novelty: This technology is a method and a system of using non-labeled antimetabolites (purine-, pyrimidine- and folate- based) and their analogs as theranostic agents with MRI imaging.Value Proposition:Imaging drug delivery is of great clinical importance. Achieving...

Published: 6/27/2024 | Inventor(s): Peter van Zijl, Yuguo Li, Shibin Zhou, Bert Vogelstein, Guanshu Liu

Keywords(s): Cancers, Disease Indication, Imaging Agent, Imaging and Sensing Systems, Imaging Modality, In Vivo Medical Imaging, Magnetic Resonance Imaging (MRI)

Category(s): Technology Classifications > Medical Devices > Imaging, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology

DEC1 KO Lines for Drug Discovery

C04656: DEC1 KO Lines for Drug Discovery Technical Details: Deleted in esophageal cancer 1 (DEC1) gene knockouts of the human keratinocyte cell line, HaCaT. Details are described in the paper by Zawel et al., 2002 Looking for Partners: The cell lines described in this invention can be used in screens for novel molecules that target...

Published: 6/27/2024 | Inventor(s): Kenneth Kinzler, Leigh Zawel, Shibin Zhou, Bert Vogelstein

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Esophageal Cancer, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Ear, Nose & Throat, Clinical and Disease Specializations > Oncology > Esophageal Cancer, Technology Classifications > Research Tools > Assays, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools

Cell Lines with Targeted Deletions of SMAD4

C04311: Cell Lines with Targeted Deletions of SMAD4 Technical Details: Creation of cell lines in which the SMAD4 genes have been disrupted by targeted homologous interation.Looking for Partners: Isogenic cell lines with or without intact SMAD4 genes are valuable reagents for studying the cellular effects of TGF-b family members and for discovering...

Published: 6/27/2024 | Inventor(s): Shibin Zhou, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools