Search Results - human+cell+lines

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Isogenic SF3B1 cell lines for drug discovery

SF3B1 mutations are present in a number of cancers. These mutations cause abnormal splicing within human cells and can lead to genomic alterations that confer cancerous phenotypes. Our research has led to the creation of isogenic cell lines that have specific mutations within the SF3B1 gene, thus mimicking human cancer mutations. In addition, we have...

Published: 6/20/2024 | Inventor(s): Ben Ho Park, William Dalton

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines

GATA3 wild type MCF-7 breast cancer cells GATA3 D336fs*17 mutant CAMA1 breast cancer cells

Unmet NeedMutations in the transcription factor-encoding gene GATA3 are highly prevalent in breast cancer but the functional role of mutant GATA3 in malignancy remains unclear due in part to the absence of appropriate research tools. Human breast cancer cell lines with mutant and wild-type GATA3, including MCF-7 and CAMA1, respectively, are commercially...

Published: 6/20/2024 | Inventor(s): Josh Lauring, John Gustin

Keywords(s): Basic Research Biomarker, Breast Cancer, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool

Category(s): Clinical and Disease Specializations > Oncology > Breast Cancer, Technology Classifications > Research Tools > Cell Lines

14-3-3 Mediates a p53-Induced G2 Arrest

C03338: 14-3-3 Mediates a p53-Induced G2 Arrest Technical Details: Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/SDI1, but the basis for the G2 arrest is unknown. Through a quantitative...

Published: 6/20/2024 | Inventor(s): Heiko Hermeking, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Cell Lines, Cell Signaling, Discovery/Research Tools, Disease Indication, Gene Therapy, Human Cell Lines, In Vitro Research Tool, Molecular Switches/Receptors, Pharmakodynamic Biomarker, Research Reagent, Single, Therapeutic Matter, Therapeutics, Therapy Type, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Nucleic Acids, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Therapeutic Modalities

Partitioning of Human Mesenchymal Stem Cells based on CD107a Expression

Unmet NeedAutologous (obtained from the same individual) stem cell therapies are a promising avenue for the treatment of tissue defects, especially defects of bone and soft tissues. The burden of treating and/or repairing tissue defects is substantial: 2.2 million surgeries are performed each year to address bone defects, costing an estimating $56 billion....

Published: 6/20/2024 | Inventor(s): Aaron James

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Research Stem Cells

Efficient generation of retinal photoreceptors from stem/progenitor cells.

Unmet NeedApproximately 253 million people worldwide live with vision impairment. Of those with vision impairment, approximately 15% are blind. Most human blindness is caused by the dysfunction or death of retinal photoreceptors. For many eye disorders, there is no way to reverse photoreceptor loss, and efforts to treat vision loss are aimed at slowing...

Published: 6/20/2024 | Inventor(s): Seth Blackshaw, Brian Clark, Richard Gronostajski

Keywords(s): Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mouse Cell Lines, Therapeutic Matter, Therapeutic Substance Synthesis Method, Therapeutics, Transplants

Category(s): Clinical and Disease Specializations > Ophthalmology > Retinopathy, Technology Classifications > Therapeutic Modalities > Biologics

R-3327-AT6.3

Unmet NeedThere is increasing evidence supporting that ‘loss of function’ of metastasis suppressor genes plays an important role in cancer metastases. To help identify metastasis suppressor genes on human chromosomes, Johns Hopkins researchers have transferred individual human chromosomes into metastatic rat prostate cancer cells. Technology OverviewTo...

Published: 6/20/2024 | Inventor(s): John Isaacs

Keywords(s): Basic Research Biomarker, Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Prostate Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Prostate Cancer

ESR1 Mutations in Human Breast Cancer Cells

TITLE ESR1 mutations in human breast cancer cells CASE NUMBER C13950 ABSTRACT Newly discovered mutations in the estrogen receptor alpha gene, ESR1, are thought to predict for resistance to certain endocrine therapies in breast cancers that express hormone receptors. FEATURES Johns...

Published: 6/20/2024 | Inventor(s): David Chu, Ben Ho Park

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Target-based Screening Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

HDL2 iPSCs

Invention Novelty: Generation of three lines of induced pluripotent stem cells derived from fibroblast cell lines developed from patients with Huntington's disease-like 2.Value Proposition: HDL2, discovered and genetically defined by the Margolis group, is a rare, autosomal dominant neurodegenerative disorder, clinically and neuropathologically...

Published: 6/20/2024 | Inventor(s): Russell Margolis, Christopher Ross, Dobrila Rudnicki, Hongjun Song, Sergey Akimov

Keywords(s): Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Immortalized Human Schwann Cell Line

UNMET NEEDSchwann cells (SCs) play an important role in the pathogenesis of peripheral nerve diseases. However, use of primary human SCs (hSCs) for in vitro models is limited because these cells are difficult to prepare and maintain in high yield and purity under common cell culture conditions.FEATURESTo circumvent this obstacle, the inventor immortalized...

Published: 6/20/2024 | Inventor(s): Ahmet Hoke

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines

Generation of stable mouse neuroblastoma N2a cells that express either wild-type human APP695 N2a APP695wt or human APP695swe N2a APP695swe

INVENTION NOVELTY: Researchers have generated transgenic mouse N2a neuroblastoma cells that stably express wild-type or mutated APP, respectively. C-terminally myc-tagged wild-type APP, or APP carrying the Swedish familial Alzheimer's disease (FAD)-specific amino acid substitution were cloned in plasmid pCB6 under control of CMV promoter. Next,...

Published: 6/20/2024 | Inventor(s): Sangram Sisodia

Keywords(s): Cancers, Cell Lines, Discovery/Research Tools, Disease Indication, Human Cell Lines, In Vitro Research Tool, Mouse Cell Lines

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

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