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Search Results - human+cell+lines
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A Novel-fate Marking Strategy to Permanently Tag Hypoxic Cancer Cells
Value Proposition· Permanently labels cells that have experienced hypoxia, enabling long-term tracking· Captures tumor evolution by identifying cells with past hypoxia exposure, not just at the time of tissue collection· Enables investigation of metastasis by tracking cells from hypoxic niches that may retain aggressive phenotypes· Supports...
Published: 1/22/2026
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Inventor(s):
Daniele Gilkes
,
Ines Godet
Keywords(s):
Breast Cancer
,
Cancers
,
Cardiovascular Diseases
,
Cell Lines
,
Discovery/Research Tools
,
Disease Indication
,
Human Cell Lines
,
In Vitro Research Tool
,
In Vivo Research Tool
,
Mouse Model
,
Translational Research Biomarker
Category(s):
Clinical and Disease Specializations > Oncology
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Clinical and Disease Specializations > Cardiovascular
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Technology Classifications > Research Tools > Animal Models
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Technology Classifications > Research Tools > Cell Lines
Muscular Dystrophy Cell Lines
Unmet NeedFacioscapulohumeral muscular dystrophy (FSHD) is a complex neuromuscular disorder affecting 1 in 20,000 individuals. The disease is characterized by progressive wasting of facial, upper arm and shoulder girdle muscles. FSHD has variable age of onset, ranging from infant to late adult; and approximately one-third of patients lose the ability...
Published: 1/22/2026
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Inventor(s):
Kathryn Wagner
Keywords(s):
Cell Lines
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CNS and Neurological Disorders
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Discovery/Research Tools
,
Disease Indication
,
Human Cell Lines
,
In Vitro Research Tool
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Muscular Dystrophy
Category(s):
Technology Classifications > Research Tools > Cell Lines
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Clinical and Disease Specializations > Musculoskeletal > Muscle Atrophy
SCA12 Tools – SCA12 Fibroblasts, iPSCs and Polyclonal Antibodies to Investigate SCA12
Value PropositionFirst in class patient-derived biological tools for investigation of SCA12, a rare neurodegenerative disease with no known cure. Unmet NeedSpinocerebellar ataxia type 12 (SCA12) is a rare neurodegenerative disease that affects the cerebellum, commonly resulting in upper limb tremors and muscle spasms, with some patients reporting a...
Published: 1/22/2026
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Inventor(s):
Russell Margolis
,
Pan Li
,
Christopher Ross
Keywords(s):
Basic Research Biomarker
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Cell Lines
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Discovery/Research Tools
,
Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools >
Human Cell Lines
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Clinical and Disease Specializations > Neurology > Neurodegeneration
K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells
C10037: K-ras Knock in Human Breast Non-tumorigenic Breast Epithelial Cells Technical Details: Single oncogenic point mutation in codon 12 of K-Ras was "knocked in" to the commercially available MCF-l0A cell line and two other hTERT immortalized human breast epithelial cell lines. Looking for Partners: The cell lines described in this...
Published: 1/22/2026
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Inventor(s):
Ben Ho Park
Keywords(s):
Basic Research Biomarker
,
Cell Lines
,
Cell Model
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Discovery/Research Tools
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Epithelial Cells
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Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools >
Human Cell Lines
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Technology Classifications > Research Tools
Isogenic SF3B1 cell lines for drug discovery
SF3B1 mutations are present in a number of cancers. These mutations cause abnormal splicing within human cells and can lead to genomic alterations that confer cancerous phenotypes. Our research has led to the creation of isogenic cell lines that have specific mutations within the SF3B1 gene, thus mimicking human cancer mutations. In addition, we have...
Published: 1/22/2026
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Inventor(s):
Ben Ho Park
,
William Dalton
Keywords(s):
Cell Lines
,
Discovery/Research Tools
,
Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools > Cell Lines
,
Technology Classifications > Research Tools >
Human Cell Lines
14-3-3 Mediates a p53-Induced G2 Arrest
C03338: 14-3-3 Mediates a p53-Induced G2 Arrest Technical Details: Exposure of colorectal cancer (CRC) cells to ionizing radiation results in a cell-cycle arrest in G1 and G2. The G1 arrest is due to p53-mediated induction of the cyclin-dependent kinase inhibitor p21WAF1/CIP1/SDI1, but the basis for the G2 arrest is unknown. Through a quantitative...
Published: 1/22/2026
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Inventor(s):
Heiko Hermeking
,
Kenneth Kinzler
,
Bert Vogelstein
Keywords(s):
Biomarker
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Cancers
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Cell Lines
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Cell Signaling
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Discovery/Research Tools
,
Disease Indication
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Gene Therapy
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Human Cell Lines
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In Vitro Research Tool
,
Molecular Switches/Receptors
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Pharmakodynamic Biomarker
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Research Reagent
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Single
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Therapeutic Matter
,
Therapeutics
,
Therapy Type
,
Translational Research Biomarker
Category(s):
Clinical and Disease Specializations
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Clinical and Disease Specializations > Oncology
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Technology Classifications > Research Tools > Nucleic Acids
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Technology Classifications > Diagnostics > Biomarkers
,
Technology Classifications > Therapeutic Modalities > Targets
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Technology Classifications > Research Tools > Proteins, Ligands & Receptors
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Technology Classifications > Diagnostics
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Technology Classifications > Research Tools
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Technology Classifications > Therapeutic Modalities
Partitioning of Human Mesenchymal Stem Cells based on CD107a Expression
JHU Ref #: C15392Value PropositionImproved Stem Cell Isolation: Enables efficient and scalable separation of stem cells predisposed to fat or bone tissue regeneration.Clinically Feasible: Uses magnetic-activated cell sorting (MACS), a cost-effective and translational alternative to fluorescence-activated cell sorting (FACS).Enhanced Therapy Potential: Optimized...
Published: 1/22/2026
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Inventor(s):
Aaron James
Keywords(s):
Cell Lines
,
Discovery/Research Tools
,
Human Cell Lines
,
In Vitro Research Tool
Category(s):
Technology Classifications > Research Tools >
Human Cell Lines
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Technology Classifications > Research Tools > Research Stem Cells
Efficient generation of retinal photoreceptors from stem/progenitor cells.
Unmet NeedApproximately 253 million people worldwide live with vision impairment. Of those with vision impairment, approximately 15% are blind. Most human blindness is caused by the dysfunction or death of retinal photoreceptors. For many eye disorders, there is no way to reverse photoreceptor loss, and efforts to treat vision loss are aimed at slowing...
Published: 1/22/2026
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Inventor(s):
Seth Blackshaw
,
Brian Clark
,
Richard Gronostajski
Keywords(s):
Cell Lines
,
Discovery/Research Tools
,
Disease Indication
,
Human Cell Lines
,
In Vitro Research Tool
,
Mouse Cell Lines
,
Therapeutic Matter
,
Therapeutic Substance Synthesis Method
,
Therapeutics
,
Transplants
Category(s):
Clinical and Disease Specializations > Ophthalmology > Retinopathy
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Technology Classifications > Therapeutic Modalities > Biologics
R-3327-AT6.3
Unmet NeedThere is increasing evidence supporting that ‘loss of function’ of metastasis suppressor genes plays an important role in cancer metastases. To help identify metastasis suppressor genes on human chromosomes, Johns Hopkins researchers have transferred individual human chromosomes into metastatic rat prostate cancer cells. Technology OverviewTo...
Published: 1/22/2026
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Inventor(s):
John Isaacs
Keywords(s):
Basic Research Biomarker
,
Cancers
,
Cell Lines
,
Discovery/Research Tools
,
Disease Indication
,
Human Cell Lines
,
In Vitro Research Tool
,
Prostate Cancer
Category(s):
Clinical and Disease Specializations
,
Clinical and Disease Specializations > Men's Health
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Technology Classifications > Research Tools > Cell Lines
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Technology Classifications > Research Tools >
Human Cell Lines
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Clinical and Disease Specializations > Oncology
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Technology Classifications > Research Tools
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Clinical and Disease Specializations > Oncology > Prostate Cancer
ESR1 Mutations in Human Breast Cancer Cells
TITLE ESR1 mutations in human breast cancer cells CASE NUMBER C13950 ABSTRACT Newly discovered mutations in the estrogen receptor alpha gene, ESR1, are thought to predict for resistance to certain endocrine therapies in breast cancers that express hormone receptors. FEATURES Johns...
Published: 1/22/2026
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Inventor(s):
David Chu
,
Ben Ho Park
Keywords(s):
Cell Lines
,
Discovery/Research Tools
,
Human Cell Lines
,
In Vitro Research Tool
,
Target-based Screening Tool
,
Translational Research Biomarker
Category(s):
Technology Classifications > Research Tools
,
Technology Classifications > Research Tools >
Human Cell Lines
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