Search Results - russell+margolis

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HDL2 iPSCs

Invention Novelty: Generation of three lines of induced pluripotent stem cells derived from fibroblast cell lines developed from patients with Huntington's disease-like 2.Value Proposition: HDL2, discovered and genetically defined by the Margolis group, is a rare, autosomal dominant neurodegenerative disorder, clinically and neuropathologically...

Published: 3/13/2025 | Inventor(s): Russell Margolis, Christopher Ross, Dobrila Rudnicki, Hongjun Song, Sergey Akimov

Keywords(s): Cell Lines, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Human Cell Lines, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

Multiple Lines of Induced Pluripotent Stem Cells (iPSCs) Derived from Members of an American Family with, and without DISC1 Mutations Associated with Schizophrenia and Depression

Invention Novelty: These tangible materials are induced Pluripotent Stem Cells (iPSCs) derived from members with or without DISC1 (Disrupted in schizophrenia 1) mutations in an American family associated with schizophrenia. Value Proposition:Mutations in DISC1 have been shown to predispose individuals to the development of psychiatric illnesses such...

Published: 3/13/2025 | Inventor(s): Hongjun Song, Christopher Ross, Guo-li Ming, Russell Margolis

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Schizophrenia, Stem Cells, Target-based Screening Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools > Human Cell Lines

Assays to Detect Small Molecules that Suppress Expression of the Mutant Huntington Disease Gene

ABSTRACTHuntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by a mutation in the huntingtin gene (HTT). JHU researchers approach to finding a treatment for HD is two-fold: 1) to find small molecules (that could be developed into clinically useful drugs) that can directly suppress expression of HTT by blocking activity...

Published: 3/13/2025 | Inventor(s): Russell Margolis, Dobrila Rudnicki, Wang Zheng, Pan Li, Xin Sun

Keywords(s): Assay, Clinical Diagnostics, CNS and Neurological Disorders, Disease Indication, Huntington's Disease, In Vitro Diagnostics, Neurodegeneration

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools > Assays, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools

CUG Expressing tg Mice

C11471: Junctophilin 3 (JPH3) Transgenic Mice Expressing Consecutive CUG Triplets Value Proposition: These transgenic mouse models express a short untranslatable fragment of exon 2A of the gene junctophilin 3 (JPH3) containing either 10 or 100 consecutive CUG triplets in the brain. Relevant publication: Rudnicki et al. Huntington's disease-like...

Published: 3/13/2025 | Inventor(s): Lino Tessarollo, Russell Margolis, Christopher Ross, Dobrila Rudnicki

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vivo Research Tool, Knock In Mouse Model, Mouse Model

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools

iPSCs from Schizophrenia patents with a DISC1 mutation

C11364: Schizophrenia Associated Induced Pluripotent Stem Cell LinesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from somatic cells from members of an American family with schizophrenia and without a schizophrenia diagnosisValue Proposition: Mutations in the Disrupted-in-Schizophrenia 1 (DISC1) gene have been shown to predispose individuals...

Published: 3/13/2025 | Inventor(s): Guo-li Ming, Christopher Ross, Russell Margolis, Hongjun Song

Keywords(s): Basic Research Biomarker, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Schizophrenia, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools

HD-iPSC Lines

C11143: Huntingtons Disease Associated iPSC linesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from patients with Huntingtons disease (HD).Value Proposition: HD is a devastating and fatal hereditary neurodegenerative disorder with no current cure. Although numerous cell culture and animal models exist, the preferential neuron degeneration...

Published: 3/13/2025 | Inventor(s): Guo-li Ming, Russell Margolis, Christopher Ross, Hongjun Song

Keywords(s): Basic Research Biomarker, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Neurodegenerative Diseases, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines