Search Results - guo-li+ming

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SpinΩ – A Multi-well Bioreactor for Culturing 3D Organoids

UNMET NEEDSpinning bioreactors have been used for three-dimensional (3D) cell culture and generation of organ-like tissues (organoids). However, current spinning bioreactors available on the market (e.g. the Corning® disposable spinner flasks) have several major challenges including requiring a large volume of medium and incubator space, large sample-to-sample...

Published: 6/27/2024 | Inventor(s): Hongjun Song, Guo-li Ming, Mingxi Song, Christopher Hadiono, William Jeang, Ha Nam Nguyen, Xuyu Qian

Keywords(s): Bioreactor-based Manufacturing, Cell Model, Discovery/Research Tools, In Vitro Research Tool, Industrial Manufacturing, Research Instrument, Stem Cells

Category(s): Technology Classifications > Research Tools, Technology Classifications > Industrial Tech > Bioreactors, Technology Classifications > Industrial Tech > Industrial Manufacturing, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Industrial Tech, Technology Classifications > Engineering Tech > Bioreactors, Technology Classifications > Engineering Tech > Industrial Manufacturing

Novel Therapeutic Target for Neural Regeneration, Stroke and Anti-depressants

Unmet needCurrent anti-depressants in the market have various limitations including lack of broad-spectrum drugs, unexpected side effects, toxicity and low efficacy for certain patients. New generation of anti-depressants based on most recent biomedical discoveries concerning depression are urgently needed. Technology overviewJohns Hopkins researchers...

Published: 6/27/2024 | Inventor(s): Dengke Ma, Guo-li Ming, Hongjun Song

Keywords(s): Biomarker, CNS and Neurological Disorders, Disease Indication, Mechanism of Action Biomarker, Psychiatric Diseases, Stroke, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Neurology > Stroke, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Targets

Prostate-specific Membrane Antigen Targeted Plasmon-enhanced Raman Spectroscopy Reporters for Molecular Imaging of Prostate Cancer

Unmet Need:Non-invasive assessment of tumor burden and cancer-selective treatment in prostate cancer. This approach is will allow visualization in real-time of the distribution and action of therapeutic agents in vivo by transducing the presence of PSMA at the tissue level to characteristic Raman spectral patterns. This nanoplex platform, therefore,...

Published: 6/27/2024 | Inventor(s): Ishan Barman, Ming Li, Martin Pomper, Sangeeta Ray

Keywords(s): Cancers, Disease Indication, Imaging Agent, Imaging and Sensing Systems, In Vivo Medical Imaging, Non-novel, Predicted Novelty, Prostate Cancer, Small Molecules, Therapeutic Matter, Therapeutic Substance, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Men's Health, Clinical and Disease Specializations > Oncology > Prostate Cancer, Technology Classifications > Medical Devices > Imaging, Technology Classifications > Therapeutic Modalities > Small Molecules, Technology Classifications > Medical Devices, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities

Multiple Lines of Induced Pluripotent Stem Cells (iPSCs) Derived from Members of an American Family with, and without DISC1 Mutations Associated with Schizophrenia and Depression

Invention Novelty: These tangible materials are induced Pluripotent Stem Cells (iPSCs) derived from members with or without DISC1 (Disrupted in schizophrenia 1) mutations in an American family associated with schizophrenia. Value Proposition:Mutations in DISC1 have been shown to predispose individuals to the development of psychiatric illnesses such...

Published: 6/27/2024 | Inventor(s): Hongjun Song, Christopher Ross, Guo-li Ming, Russell Margolis

Keywords(s): Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Schizophrenia, Stem Cells, Target-based Screening Tool, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools > Human Cell Lines

Kir2.1 (mouse) Stable Cell Line

TITLEKir2.1 (mouse) Stable Cell Line CASE NUMBERC12936 ABSTRACTThe Kir2.1 channel (KCNJ2) is a member of inwardly-rectifying potassium channels, expressing two transmembrane-spanning segments, flanking a conserved pore region. Inward rectifier K+ channels pass prominent inward currents, and mediate the cardiac inwardly-rectifying potassium current (IK1),...

Published: 6/27/2024 | Inventor(s): Haiyan Sun, Min Li

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

iPSCs from Schizophrenia patents with a DISC1 mutation

C11364: Schizophrenia Associated Induced Pluripotent Stem Cell LinesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from somatic cells from members of an American family with schizophrenia and without a schizophrenia diagnosisValue Proposition: Mutations in the Disrupted-in-Schizophrenia 1 (DISC1) gene have been shown to predispose individuals...

Published: 6/27/2024 | Inventor(s): Guo-li Ming, Christopher Ross, Russell Margolis, Hongjun Song

Keywords(s): Basic Research Biomarker, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, In Vitro Research Tool, Psychiatric Diseases, Schizophrenia, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Psychiatry > Schizophrenia, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Psychiatry, Technology Classifications > Research Tools

HD-iPSC Lines

C11143: Huntingtons Disease Associated iPSC linesNovelty: Induced Pluripotent Stem Cell (iPSC) lines derived from patients with Huntingtons disease (HD).Value Proposition: HD is a devastating and fatal hereditary neurodegenerative disorder with no current cure. Although numerous cell culture and animal models exist, the preferential neuron degeneration...

Published: 6/27/2024 | Inventor(s): Guo-li Ming, Russell Margolis, Christopher Ross, Hongjun Song

Keywords(s): Basic Research Biomarker, Cell Model, CNS and Neurological Disorders, Discovery/Research Tools, Disease Indication, Huntington's Disease, In Vitro Research Tool, Neurodegeneration, Neurodegenerative Diseases, Stem Cells

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology > Huntington's Disease, Clinical and Disease Specializations > Neurology > Neurodegeneration, Clinical and Disease Specializations > Rare Diseases, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Stem Cells, Clinical and Disease Specializations > Neurology, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Human Cell Lines

Instrument System for Managing and Cherry Picking Microorganism Collections

Value Proposition: Currently, no commercial liquid handler exists that can transfer biomaterials from freezer storage to a destination plate for subsequent experimental manipulation. The novel retrieval module could be integrated to various models of robotic freezers and liquid handling systems and increase throughput while eliminating contamination...

Published: 6/27/2024 | Inventor(s): Shunyou Long, Min Li, Heng Zhu, Jef Boeke

Keywords(s): Basic Research Biomarker, Discovery/Research Tools, In Vitro Research Tool, Research Instrument

Category(s): Technology Classifications > Research Tools

Monitoring Functional Kinetics of Vesicular Trafficking - Evidence for "Sleeping" Membrane Receptors on Cell Surface

C04462: Monitoring Functional Kinetics of Vesicular Trafficking - Evidence for "Sleeping" Membrane Receptors on Cell Surface Technical Details: The present inventive method is designed to measure the rate of protein trafficking to cell surface. Such measurement may be used to determine the physiological state of cells under different conditions...

Published: 6/27/2024 | Inventor(s): Sojin Shikano, Haiyan Sun, Min Li

Keywords(s): Cell Signaling, Discovery/Research Tools, Molecular Switches/Receptors, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools