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Genetic Alterations in Medulloblastomas - MLL Genes as Targets for Diagnosis and Therapeutics

Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations,...

Published: 6/27/2024 | Inventor(s): Xiaosong Zhang, Hai Yan, Gregory Riggins, Victor Velculescu, Kenneth Kinzler, Darell Bigner, Nickolas Papadopoulos, Donald Parsons, Sian Jones, Rebecca Leary, Meng Li, Bert Vogelstein

Keywords(s): Biomarker, Brain Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Medulloblastoma, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Medulloblastoma

Compositions and Biomarkers for Human Cancer and Methods of Use

Novel biomarkers for the detection and prognosis of several cancersJHU REF: C12506 Invention novelty: This invention has discovered high frequency mutations in the telomerase reverse transcriptase (TERT) promoter of certain cancers. Value Proposition: Early detection is usually critical for the successful treatment of cancer, therefore there is...

Published: 6/27/2024 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Chetan Bettegowda, Yuchen Jiao, Darell Bigner, Hai Yan, Zachary Reitman, Patrick Killela

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Kir2.1 (mouse) Stable Cell Line

TITLEKir2.1 (mouse) Stable Cell Line CASE NUMBERC12936 ABSTRACTThe Kir2.1 channel (KCNJ2) is a member of inwardly-rectifying potassium channels, expressing two transmembrane-spanning segments, flanking a conserved pore region. Inward rectifier K+ channels pass prominent inward currents, and mediate the cardiac inwardly-rectifying potassium current (IK1),...

Published: 6/27/2024 | Inventor(s): Haiyan Sun, Min Li

Keywords(s): Basic Research Biomarker, Cell Lines, Discovery/Research Tools, In Vitro Research Tool, Mouse Cell Lines

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools

Identification of Chromosome 1 and Chromosome 19 Genes Contributing to Oligodendrogliomagenesis

C11619: Novel Molecular Diagnostic for Brain CancerNovelty: The invention is novel genetic mutations to genes CIC and FUBP1 not previously associated with oligodendrogliomagenesis, the second most common malignant brain tumor type in adults.Value Proposition: The inventors indentified unreported changes in a gene’s amino acid sequence that appears...

Published: 6/27/2024 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Nishant Agrawal, Chetan Bettegowda, Darell Bigner, Hai Yan, Roger Mclendon

Keywords(s): Biomarker, Brain Cancer, Cancers, Clinical Diagnostics, CNS and Neurological Disorders, Diagnostic Biomarker, Discovery/Research Tools, Disease Indication, Fly Model, In Vitro Diagnostics (Old), In Vitro Research Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Animal Models, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Brain Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Neurology

Mutations of ATRX in Brain Tumors

C11618: Novel Molecular Diagnostic for Aggressive Brain TumorsNovelty: A genetic mutation in the ATRX or DAXX genes previously unknown for its presence in various aggressive brain tumors was discovered and thereby provides an attractive diagnostic opportunity.Value Proposition: Previously unreported changes in ATRX or DAXX gene’s amino acid sequence...

Published: 6/27/2024 | Inventor(s): Luis Diaz, Alan Meeker, Hai Yan, Nickolas Papadopoulos, Darell Bigner, Yuchen Jiao, Ralph Hruban, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Biomarker, Brain Cancer, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Monitoring Functional Kinetics of Vesicular Trafficking - Evidence for "Sleeping" Membrane Receptors on Cell Surface

C04462: Monitoring Functional Kinetics of Vesicular Trafficking - Evidence for "Sleeping" Membrane Receptors on Cell Surface Technical Details: The present inventive method is designed to measure the rate of protein trafficking to cell surface. Such measurement may be used to determine the physiological state of cells under different conditions...

Published: 6/27/2024 | Inventor(s): Sojin Shikano, Haiyan Sun, Min Li

Keywords(s): Cell Signaling, Discovery/Research Tools, Molecular Switches/Receptors, Research Reagent, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Proteins, Ligands & Receptors, Technology Classifications > Research Tools