Search Results - ralph+hruban

7 Results

Sort By:

Identification of RNF43 Mutations in Pancreatic Cysts

Unmet Need· One third of diagnoses for surgical resection of pancreatic cysts are incorrect, leading to unnecessary surgery, medical risk, and high costs (Hammel, 2002). The current standard of care for determining pancreatic cyst type is based solely on symptom progression and imaging criteria, and histopathological analysis is only available...

Published: 9/26/2024 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Jian Wu, Anirban Maitra, Ralph Hruban, Marco Dal Molin

Keywords(s): Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, Nucleotide, Pancreatic Cancer, Research Reagent, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Computational method for the 3D reconstruction and multi-labelling of serially sectioned tissue

Unmet Need / Invention Novelty: Three-dimensional (3D) tissue reconstruction permits analyses of the relationships between cellular factors, tissue structure, and diseasepathology.Current methods used to visualize and quantify tissue structures in 3D space are limited to small volumes and have various constraints relating to consistency, information...

Published: 9/27/2024 | Inventor(s): Denis Wirtz, Ashley Kiemen, Pei-Hsun Wu, Ralph Hruban, Laura Wood, Alexandra Sneider, Luo Gu, Mehran Habibi, Joo Ho Kim

Keywords(s):

Category(s): Technology Classifications > Research Tools

Johns Hopkins Atlas of Ovarian Tumor Pathology iPad App

Unmet NeedOvarian cancer is the most common cancer in women and is the fifth leading cause of cancer death in women. Every year, a quarter of a million women around the world are diagnosed with ovarian cancer. The treatment for ovarian cancer is most effective when the cancer is caught early. In order to improve early diagnosis of ovarian cancer, residents,...

Published: 9/27/2024 | Inventor(s): Ralph Hruban, Emanuela Veras, Ayse Ayhan, Tsui-Lien Mao, Marissa White, Norman Barker, Toby Cornish

Keywords(s): Cancers, Disease Indication, Ovarian Cancer, Trademark

Category(s): Clinical and Disease Specializations > Oncology > Ovarian Cancer, Technology Classifications > Computers, Electronics & Software > Education Tech, Trademark

The Johns Hopkins iCareBook for Pancreatic Cancer

Unmet NeedPancreatic cancer is the uncontrolled growth of cells starting at the pancreas, a glandular organ which secretes enzymes and hormones which help regulate the digestive system. Pancreatic cancer develops rapidly due to aggressive tumor cell biology. Survival rate is low with approximately 8% of those diagnosed surviving the first five years...

Published: 9/26/2024 | Inventor(s): Toby Cornish, Na'im Fanaian, Katie Eun, Ralph Hruban

Keywords(s): Disease Management System, Healthcare Management, Operations Management

Category(s): Technology Classifications > Computers, Electronics & Software > Clinical Management, Technology Classifications > Computers, Electronics & Software > Healthcare IT, Technology Classifications > Computers, Electronics & Software

PALB2 Gene Mutations Identify Susceptibility to DNA Damaging Agents

PALB2 Gene Mutations Identify Susceptibility to DNA Damaging AgentsJHU Ref #: C10869Unmet NeedPancreatic cancer is predicted to be the second leading cause of cancer-related death by 2030 (Siegel et al., 2020). However, many patients present with advanced disease, and typical broad-spectrum chemotherapeutic treatments are often insufficient. Precision...

Published: 9/26/2024 | Inventor(s): Ralph Hruban, Bert Vogelstein, Kenneth Kinzler, Victor Velculescu, Scott Kern, Sian Jones, Michael Goggins, Manuel Hidalgo, Alison Klein, James Eshleman, Donald Parsons

Keywords(s): Biomarker, Clinical Diagnostics, In Vitro Diagnostics, Risk Stratification

Category(s): Technology Classifications > Computers, Electronics & Software > Precision Medicine Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Computers, Electronics & Software, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Precision Medicine Tools

Mutations of ATRX in Brain Tumors

C11618: Novel Molecular Diagnostic for Aggressive Brain TumorsNovelty: A genetic mutation in the ATRX or DAXX genes previously unknown for its presence in various aggressive brain tumors was discovered and thereby provides an attractive diagnostic opportunity.Value Proposition: Previously unreported changes in ATRX or DAXX gene’s amino acid sequence...

Published: 9/26/2024 | Inventor(s): Luis Diaz, Alan Meeker, Hai Yan, Nickolas Papadopoulos, Darell Bigner, Yuchen Jiao, Ralph Hruban, Kenneth Kinzler, Bert Vogelstein

Keywords(s): Basic Research Biomarker, Biomarker, Brain Cancer, Cancer Cells, Cancers, Cell Model, Clinical Diagnostics, Discovery/Research Tools, Disease Indication, In Vitro Diagnostics (Old), In Vitro Research Tool

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Clinical and Disease Specializations > Oncology > Brain Cancer, Technology Classifications > Research Tools > Cell Lines, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers

DAXX/A TRX genes provide prognostic information in cancers

C11331: Methods and Biomarkers for the detection of Pancreatic Neuroendrocrine TumorsValue Proposition: • Mutations useful to accurately diagnose a patient with pancreatic neuroendocrine tumor • Novel prognostic indicators that predict clinical outcome • Genetic mutations identified that are useful to select and implement an appropriate...

Published: 9/26/2024 | Inventor(s): Nickolas Papadopoulos, Victor Velculescu, Luis Diaz, Yuchen Jiao, Kenneth Kinzler, Ralph Hruban, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Pancreatic Cancer, Prognostic Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Prognostics Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities