Search Results - nickolas+papadopoulos

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Detection of Cancer in Body Fluids Using Cell Enrichment and Flow Cytometry

Unmet NeedEarly detection of cancer is critical for diagnosis, informing treatment, and improving prognostic outcomes. Solid biopsies can be difficult to obtain and provide limited information on tumor composition. In recent years, liquid biopsies have allowed for non-invasive testing of circulating tumor-derived components, such as tumor cells or nucleic...

Published: 6/21/2024 | Inventor(s): Jonathan Dudley, Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos

Keywords(s):

Category(s): Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Precision Medicine Tools, Technology Classifications > Diagnostics > Companion Diagnostics, Clinical and Disease Specializations > Oncology

Identification of RNF43 Mutations in Pancreatic Cysts

Unmet Need· One third of diagnoses for surgical resection of pancreatic cysts are incorrect, leading to unnecessary surgery, medical risk, and high costs (Hammel, 2002). The current standard of care for determining pancreatic cyst type is based solely on symptom progression and imaging criteria, and histopathological analysis is only available...

Published: 6/20/2024 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Jian Wu, Anirban Maitra, Ralph Hruban, Marco Dal Molin

Keywords(s): Cancers, Cloning Reagents, Discovery/Research Tools, Disease Indication, Nucleotide, Pancreatic Cancer, Research Reagent, Translational Research Biomarker

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Gastroenterology, Technology Classifications > Research Tools > Nucleic Acids, Clinical and Disease Specializations > Oncology, Technology Classifications > Research Tools, Clinical and Disease Specializations > Oncology > Pancreatic Cancer, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > Diagnostic Biomarkers

Repetitive Element Aneuploidy Sequencing Systems (REAL-SeqS)

Unmet NeedAneuploidies are chromosomal alterations that are present in the majority of cancers and associated with numerous genetic disorders. Consequently, the detection of aneuploidy in clinical samples has important applications in prenatal testing and cancer diagnostics. The current, noninvasive methods for detecting aneuploidy in clinical samples...

Published: 6/20/2024 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Christopher Douville, Nickolas Papadopoulos, Cristian Tomasetti

Keywords(s): Analytical Method, Discovery/Research Tools, In Vitro Research Tool

Category(s): Technology Classifications > Research Tools > Nucleic Acids

Genetic Alterations in Medulloblastomas - MLL Genes as Targets for Diagnosis and Therapeutics

Medulloblastoma (MB) is the most common malignant brain tumor of children. To identify the genetic alterations in this tumor type, we searched for copy number alterations using high density microarrays and sequenced all known protein-coding genes and miRNA genes using Sanger sequencing. We found that, on average, each tumor had 11 gene alterations,...

Published: 6/20/2024 | Inventor(s): Xiaosong Zhang, Hai Yan, Gregory Riggins, Victor Velculescu, Kenneth Kinzler, Darell Bigner, Nickolas Papadopoulos, Donald Parsons, Sian Jones, Rebecca Leary, Meng Li, Bert Vogelstein

Keywords(s): Biomarker, Brain Cancer, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Medulloblastoma, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Neurology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Clinical and Disease Specializations > Oncology > Brain Cancer, Clinical and Disease Specializations > Oncology > Medulloblastoma

Compositions and Biomarkers for Human Cancer and Methods of Use

Novel biomarkers for the detection and prognosis of several cancersJHU REF: C12506 Invention novelty: This invention has discovered high frequency mutations in the telomerase reverse transcriptase (TERT) promoter of certain cancers. Value Proposition: Early detection is usually critical for the successful treatment of cancer, therefore there is...

Published: 6/20/2024 | Inventor(s): Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Chetan Bettegowda, Yuchen Jiao, Darell Bigner, Hai Yan, Zachary Reitman, Patrick Killela

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Prognostic Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics > Diagnostic Biomarkers, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Microsatellite Instability as a Pharmacogenomic Marker of Therapeutic Response to Immune Checkpoint Inhibition

TITLEMicrosatellite Instability as a Pharmacogenomic Marker of Therapeutic Response to Immune Checkpoint Inhibition CASE NUMBER C13241UNMET NEEDThe programmed death 1 (PD-1) pathway is a negative feedback system that represses Th1 cytotoxic immune responses and that, if unregulated, can damage the host. It is up-regulated in many tumors...

Published: 6/20/2024 | Inventor(s): Luis Diaz, Bert Vogelstein, Kenneth Kinzler, Nickolas Papadopoulos, Dung Le, Drew Pardoll, Suzanne Topalian

Keywords(s): Biomarker, Clinical Diagnostics, In Vitro Diagnostics, Pharmakodynamic Biomarker

Category(s): Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Diagnostics

Exomic sequences of ovarian clear cell carcinomas

Ovarian Clear Cell Carcinoma (OCCC) is an aggressive cancer that is generally resistant to therapy. To gain novel insights into the genetic origin of this tumor type, we determined the exomic sequences of eight tumors after immunoaffinity purification of neoplastic cells. Through comparison to normal cells from the same patients, we identified four...

Published: 6/20/2024 | Inventor(s): Sian Jones, Victor Velculescu, Kenneth Kinzler, Nickolas Papadopoulos, Ie-Ming Shih, Bert Vogelstein

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Ovarian Cancer

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology > Ovarian Cancer, Clinical and Disease Specializations > Women's Health, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics, Technology Classifications > Diagnostics > In Vitro Diagnostics, Clinical and Disease Specializations > Oncology

Mutational Signature of Aristolochic Acid Exposure

Diagnostic for Environmental Carcinogen for Bladder CancerJHU REF: [C12638] Invention novelty: a comprehensive panel of biomarkers for aristolochic acid, an environmental carcinogen for urothelial carcinoma, the most common form of bladder cancer Value Proposition Early detection is usually critical for the successful treatment of cancer, therefore...

Published: 6/20/2024 | Inventor(s): Nickolas Papadopoulos, Kathleen Dickman, Arthur Grollman, Thomas Rosenquist, Margaret Hoang, Masaaki Moriya, Bert Vogelstein, Kenneth Kinzler

Keywords(s): Biomarker, Cancers, Clinical Diagnostics, Diagnostic Biomarker, Disease Indication, In Vitro Diagnostics, Mechanism-of-action Biomarker, Therapeutic Matter, Therapeutics

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Diagnostics > Biomarkers, Technology Classifications > Diagnostics > In Vitro Diagnostics, Technology Classifications > Therapeutic Modalities > Targets, Technology Classifications > Diagnostics, Technology Classifications > Therapeutic Modalities

Generation of Human Cell Lines with Inactivated GLUT1 Genes

TITLEGeneration of Human Cell Lines with Inactivated GLUT1 GenesCASE NUMBERC11819INVENTION NOVELTYTangible material involving generation of mutant isogenic, cancerous cell lines RKO and DLD1 disrupted alleles for GLUT1 protein by homologous recombination. VALUE PROPOSITIONThis tangible material can serve as an important research tool for studying the...

Published: 6/20/2024 | Inventor(s): Kenneth Kinzler, Jihye Yun, Nickolas Papadopoulos, Bert Vogelstein

Keywords(s): Cell Lines, Discovery/Research Tools, Human Cell Lines, In Vitro Research Tool, Translational Research Biomarker

Category(s): Technology Classifications > Research Tools > Cell Lines, Technology Classifications > Research Tools > Human Cell Lines, Technology Classifications > Research Tools

Autoimmunity-based Peptides as Cancer Vaccines

Autoimmunity-based Peptides as Cancer Vaccines JHU REF: C12807 Invention novelty: This technology uses autoantigen-derived peptides as novel immunotherapy to prevent and treat cancer. Value Proposition: Today, millions of people are living with cancer or have had cancer. Despite significant advances in cancer diagnosis and treatment over the...

Published: 6/20/2024 | Inventor(s): Erika Darrah, Christine Joseph, Kenneth Kinzler, Livia Casciola-Rosen, Nickolas Papadopoulos, Ami Shah, Antony Rosen, Bert Vogelstein

Keywords(s): Antigens, Biologics, Cancers, Disease Indication, Immunotherapy, Single, Therapeutic Matter, Therapeutic Substance, Therapeutics, Therapy Type, Vaccine

Category(s): Clinical and Disease Specializations, Clinical and Disease Specializations > Oncology, Technology Classifications > Therapeutic Modalities, Technology Classifications > Therapeutic Modalities > Biologics, Technology Classifications > Therapeutic Modalities > Immunotherapies, Technology Classifications > Therapeutic Modalities > Vaccines

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